Global 3D Cell Culture Market

Global 3D Cell Culture Market Size, Share, Growth Analysis, By Products(Scaffold-Based 3D cell culture, Scaffold-Free 3D cell culture), By Application(Drug Discovery, Tissue Engineering), By End User(Research Laboratories, Institutes), By By Type(hydrogel, ECM) - Industry Forecast 2023-2030


Report ID: SQMIG35G2036 | Region: Global | Published Date: February, 2024
Pages: 157 | Tables: 126 | Figures: 77

Global 3D Cell Culture Market Insights

Global 3D Cell Culture Market size was valued at USD 1.12 billion in 2021 and is poised to grow from USD 1.3 billion in 2022 to USD 4.77 billion by 2030, growing at a CAGR of 15.6% in the forecast period (2023-2030). 

The global 3D cell culture market is experiencing significant growth, driven by various factors. One key driver is the increasing efforts to develop alternatives to animal-based testing and the availability of funding programs for research. With concerns over the limitations of animal models in cellular-based studies, government organizations are promoting alternative methods for drug development. Additionally, biopharmaceutical companies' consistent focus on R&D activities for drug discovery and development, along with the adoption of 3D cell cultures in cancer research, further fuels market growth.

The rising burden of chronic diseases and the need for organ transplants have led to a demand for alternative solutions such as regenerative medicine and tissue engineering. 3D cell culture systems play a crucial role in nurturing organoids and tissue constructs for transplantation and drug response analysis. Recent product launches with improved mimicry of human body conditions support market growth.

Partnerships between pharmaceutical companies, academic institutions, and research institutes contribute to the advancement of 3D cell culture technology. Collaboration accelerates technology development, knowledge sharing, and protocol standardization, leading to increased adoption of 3D cell culture techniques. Supportive government legislation and funding from public and private organizations further drive R&D activities in the market. The robust demand for in-vitro testing models, along with organic and inorganic initiatives by market players, also facilitates market expansion. Collaborations between companies, such as the strategic collaboration between zPREDICTA, Inc. and LabCorp, and the collaboration between Merck and D1 Med, accelerate the adoption of 3D cell cultures in drug research and development. These factors collectively contribute to the growth and expansion of the global 3D cell culture market.

US 3D Cell Culture Market is poised to grow at a sustainable CAGR for the next forecast year.

Market snapshot - 2023-2030

Global Market Size

USD 1.12 billion

Largest Segment

Scaffold-based

Fastest Growth

Scaffold-based

Growth Rate

15.6% CAGR

Global 3D Cell Culture Market ($ Bn)
Country Share for North America Region (%)
Global 3D Cell Culture Market By Technology ($ Bn)
Global 3D Cell Culture Market By Technology (%)

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Global 3D Cell Culture Market Segmental Analysis

Global 3D Cell Culture Market is segmented on the basis of technology, application, end user, and region. By technology, the market is segmented into scaffold-based, scaffold-free, bioreactors, microfluidics, and bioprinting. By application, the market is segmented into Cancer research, stem cell research and tissue engineering, drug development and toxicity testing, and others. By end user, the market is segmented into biotechnology and pharmaceutical companies, academic and research institutes, hospitals, and others. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.    

Analysis By Technology

The scaffold-based technology segment is the largest segment of the global 3D cell culture market, accounting for 48.85% of the market share in 2022. This segment is expected to experience significant growth during 2023-2030 due to various factors such as increasing applications of scaffold-based cultures in tissue engineering and regenerative medicine, advancements in scaffold materials and fabrication techniques, and increasing research funding and collaboration. Hydrogels are increasingly being used as a scaffold in cell-based studies as they allow the incorporation of biochemical and mechanical signals that mimic the native extracellular matrix. Furthermore, ongoing research efforts to develop scaffold-based technologies are another factor supporting market expansion. For example, Dolomite Bio launched novel hydrogel-focused reagent kits for high-throughput encapsulation of cells in hydrogel scaffold in July 2022. Moreover, in May 2023, researchers from NUS successfully used a common plant protein to 3D print an edible cell culture scaffold.

The scaffold-free segment is expected to witness the fastest growth at a CAGR of 18.15% during the forecast period due to factors such as enhanced cellular interactions, higher throughput, and scalability, rising demand for personalized medicine, and advancements in 3D cell culture platforms and technologies. The biopharmaceutical industry and research institutes are among the key end-users driving the demand for scaffold-free systems.

Analysis By End User

The biotechnology and pharmaceutical companies segment dominated the global 3D cell culture market, accounting for 46.34% of the market share in 2022. The growth and commercial success of biopharmaceuticals and the ability of major pharmaceutical companies to leverage their portfolios have contributed to the segment's growth. 3D cell culture offers several benefits such as optimal oxygen and nutrient gradient formation and realistic cellular interactions, making it an ideal method for drug discovery and development.

On the other hand, the academic and research institutes segment is expected to register the fastest CAGR of 17.39% during 2023-2030. This can be attributed to factors such as advancements in biomedical research, increasing research activities, rising industry-academia collaboration, and significant efforts from research institutions in drug modelling and drug screening. These factors are anticipated to accelerate the growth of this segment.

 

Global 3D Cell Culture Market By Technology , 2021 (%)

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Global 3D Cell Culture Market Regional Insights

North America held the largest market share of 45.58% in 2022. This was due to factors such as advanced healthcare infrastructure, developed economies, the presence of key players, and strategic initiatives undertaken by them. Additionally, a supportive regulatory framework, government support for the development of three-dimensional culture models, and numerous research organizations and universities investigating different stem-cell based approaches are expected to further boost the regional market. For instance, the Harvard Stem Cell Institute is utilizing stem cells to revolutionize medicine for better outcomes.

The Asia Pacific region is projected to experience the highest Compound Annual Growth Rate (CAGR) of 19.74% during 2023-2030. This can be attributed to the high burden of chronic diseases, a thriving biotechnology sector, lower operating costs, and increased investments by companies in the region. Furthermore, the rising demand for cellular therapies, growing biobanks, and strong research potential are also contributing to the regional market's growth.

 

Global 3D Cell Culture Market By Geography, 2023-2030
  • Largest
  • Fastest

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Global 3D Cell Culture Market Dynamics

Drivers

Growing demand for organ transplantation

  • The increasing prevalence of chronic diseases, such as diabetes and kidney failure, has led to a rise in demand for organ transplantation. However, there is a shortage of organs available for transplantation. 3D cell culture technology can be used to develop functional organs for transplantation, which is driving the growth of the market. For example, Organovo, a biotechnology company, has developed 3D printed liver tissues for use in drug testing and transplantation research.

Restraints

Ethical concerns

  • The use of 3D cell culture technology in research has raised ethical concerns related to the use of human cells and tissues. This has led to regulatory hurdles that could impede the growth of the market.

 

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Global 3D Cell Culture Market Competitive Landscape

The global 3D cell culture market is highly competitive with the presence of several major players. Some of the key players in the market are focusing on product innovation, partnerships, collaborations, and mergers and acquisitions to expand their market presence. For example, in 2021, Corning Incorporated acquired Falcon Genomics to expand its portfolio of 3D cell culture products. Similarly, InSphero AG partnered with Roche to develop 3D cell-based assays for drug discovery and development. The market is expected to witness further consolidation as companies aim to gain a competitive edge by expanding their product portfolios and enhancing their technological capabilities.

Top Player’s Company Profile

  • Thermo Fisher Scientific Inc. (US)

  • Corning Incorporated (US)

  • Merck KGaA (Germany)

  • Lonza Group AG (Switzerland)

  • Becton, Dickinson and Company (US)

  • 3D Biotek LLC (US)

  • InSphero AG (Switzerland)

  • Synthecon Inc. (US)

  • Tecan Trading AG (Switzerland)

  • PromoCell GmbH (Germany)

  • Greiner Bio-One International GmbH (Austria)

  • Avantor, Inc. (US)

  • Sartorius AG (Germany)

  • Nano3D Biosciences, Inc. (US)

  • MIMETAS B.V. (Netherlands)

  • QGel SA (Switzerland)

  • TissUse GmbH (Germany)

  • SynVivo, Inc. (US)

  • Emulate, Inc. (US)

  • CN Bio Innovations Ltd. (UK)

Recent Developments

  • In October 2022, Corning introduced the Elplasia 12K flask, a unique microcavity geometry that simplifies spheroid formation, culture, treatment, assessment, and harvest. The flask produces around 12,000 spheroids of consistent size and shape per flask, resulting in a 125-fold greater yield than traditional 96-well spheroid plates.

  • In March 2021, Thermo Fisher Scientific launched a plasma-like medium that imitates the metabolic profile of human plasma. This cell culture medium was created to provide researchers with an accurate representation of cell growth within the human body. This novel product offers researchers an advanced tool for studying cell behavior in vitro.

 

Global 3D Cell Culture Key Market Trends

  • Growing focus on personalized medicine: There is an increasing focus on personalized medicine, which requires the development of patient-specific models for drug testing and disease modeling. 3D cell culture technology can be used to create patient-specific models that can be used for personalized drug discovery and treatment. For instance, Hubrecht Organoid Technology (HUB) has developed a platform that uses patient-derived organoids for drug testing and personalized medicine.

Global 3D Cell Culture Market SkyQuest Analysis

SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Component types team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.

According to our Global 3D Cell Culture Market analyses, the global 3D cell culture market is expected to experience significant growth in the coming years due to factors such as the increasing demand for organ transplantation, advancements in technology, and the growing focus on personalized medicine. Additionally, the market is being driven by the rising prevalence of chronic diseases, the growing biotechnology sector, and increasing investments by companies in the Asia Pacific region. However, high costs associated with 3D cell culture systems and ethical concerns related to the use of human cells and tissues are expected to restrain market growth. The market is highly competitive, with major players focusing on product innovation, partnerships, and mergers and acquisitions to expand their market presence.

 

Report Metric Details
Market size value in 2021 USD 1.12 billion
Market size value in 2030 USD 4.77 billion
Growth Rate 15.6%
Base year 2021
Forecast period 2023-2030
Forecast Unit (Value) USD Billion
Segments covered
  • Products
    • Scaffold-Based 3D cell culture, Scaffold-Free 3D cell culture, Microfluidics, 3D Bioreactors
  • Application
    • Drug Discovery, Tissue Engineering, Cancer Treatment, Regenerative medicine, Clinical, Other Applications
  • End User
    • Research Laboratories, Institutes, Biotechnology, Pharmaceutical Companies, Academic Institutes
  • By Type
    • hydrogel, ECM, hanging drop, bioreactor, microfluidics, and magnetic levitation
Regions covered North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA)
Companies covered
  • Thermo Fisher Scientific Inc. (US)

  • Corning Incorporated (US)

  • Merck KGaA (Germany)

  • Lonza Group AG (Switzerland)

  • Becton, Dickinson and Company (US)

  • 3D Biotek LLC (US)

  • InSphero AG (Switzerland)

  • Synthecon Inc. (US)

  • Tecan Trading AG (Switzerland)

  • PromoCell GmbH (Germany)

  • Greiner Bio-One International GmbH (Austria)

  • Avantor, Inc. (US)

  • Sartorius AG (Germany)

  • Nano3D Biosciences, Inc. (US)

  • MIMETAS B.V. (Netherlands)

  • QGel SA (Switzerland)

  • TissUse GmbH (Germany)

  • SynVivo, Inc. (US)

  • Emulate, Inc. (US)

  • CN Bio Innovations Ltd. (UK)

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Table Of Content

Executive Summary

Market overview

  • Exhibit: Executive Summary – Chart on Market Overview
  • Exhibit: Executive Summary – Data Table on Market Overview
  • Exhibit: Executive Summary – Chart on Global 3D Cell Culture Market Characteristics
  • Exhibit: Executive Summary – Chart on Market by Geography
  • Exhibit: Executive Summary – Chart on Market Segmentation
  • Exhibit: Executive Summary – Chart on Incremental Growth
  • Exhibit: Executive Summary – Data Table on Incremental Growth
  • Exhibit: Executive Summary – Chart on Vendor Market Positioning

Parent Market Analysis

Market overview

Market size

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • SWOT Analysis

KEY MARKET INSIGHTS

  • Technology Analysis
    • (Exhibit: Data Table: Name of technology and details)
  • Pricing Analysis
    • (Exhibit: Data Table: Name of technology and pricing details)
  • Supply Chain Analysis
    • (Exhibit: Detailed Supply Chain Presentation)
  • Value Chain Analysis
    • (Exhibit: Detailed Value Chain Presentation)
  • Ecosystem Of the Market
    • Exhibit: Parent Market Ecosystem Market Analysis
    • Exhibit: Market Characteristics of Parent Market
  • IP Analysis
    • (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
  • Trade Analysis
    • (Exhibit: Data Table: Import and Export data details)
  • Startup Analysis
    • (Exhibit: Data Table: Emerging startups details)
  • Raw Material Analysis
    • (Exhibit: Data Table: Mapping of key raw materials)
  • Innovation Matrix
    • (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
  • Pipeline product Analysis
    • (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
  • Macroeconomic Indicators

COVID IMPACT

  • Introduction
  • Impact On Economy—scenario Assessment
    • Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
  • Revised Market Size
    • Exhibit: Data Table on Global 3D Cell Culture Market size and forecast 2021-2027 ($ million)
  • Impact Of COVID On Key Segments
    • Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
  • COVID Strategies By Company
    • Exhibit: Analysis on key strategies adopted by companies

MARKET DYNAMICS & OUTLOOK

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • Regulatory Landscape
    • Exhibit: Data Table on regulation from different region
  • SWOT Analysis
  • Porters Analysis
    • Competitive rivalry
      • Exhibit: Competitive rivalry Impact of key factors, 2021
    • Threat of substitute products
      • Exhibit: Threat of Substitute Products Impact of key factors, 2021
    • Bargaining power of buyers
      • Exhibit: buyers bargaining power Impact of key factors, 2021
    • Threat of new entrants
      • Exhibit: Threat of new entrants Impact of key factors, 2021
    • Bargaining power of suppliers
      • Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
  • Skyquest special insights on future disruptions
    • Political Impact
    • Economic impact
    • Social Impact
    • Technical Impact
    • Environmental Impact
    • Legal Impact

Market Size by Region

  • Chart on Market share by geography 2021-2027 (%)
  • Data Table on Market share by geography 2021-2027(%)
  • North America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • USA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Canada
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Europe
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Germany
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Spain
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • France
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • UK
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Europe
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Asia Pacific
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • China
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • India
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Japan
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Korea
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Asia Pacific
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Latin America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Brazil
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of South America
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Middle East & Africa (MEA)
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • GCC Countries
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Africa
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of MEA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)

KEY COMPANY PROFILES

  • Competitive Landscape
    • Total number of companies covered
      • Exhibit: companies covered in the report, 2021
    • Top companies market positioning
      • Exhibit: company positioning matrix, 2021
    • Top companies market Share
      • Exhibit: Pie chart analysis on company market share, 2021(%)

Methodology

For the Global 3D Cell Culture Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:

1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.

2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Global 3D Cell Culture Market.

3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.

4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.

Analyst Support

Customization Options

With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Global 3D Cell Culture Market:

Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.

Regional Analysis: Further analysis of the Global 3D Cell Culture Market for additional countries.

Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.

Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.

Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.

Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.

Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.

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FAQs

Global 3D Cell Culture Market size was valued at USD 1.12 billion in 2021 and is poised to grow from USD 1.3 billion in 2022 to USD 4.77 billion by 2030, growing at a CAGR of 15.6% in the forecast period (2023-2030). 

  ' Thermo Fisher Scientific Inc. (US) ', ' Corning Incorporated (US) ', ' Merck KGaA (Germany) ', ' Lonza Group AG (Switzerland) ', ' Becton, Dickinson and Company (US) ', ' 3D Biotek LLC (US) ', ' InSphero AG (Switzerland) ', ' Synthecon Inc. (US) ', ' Tecan Trading AG (Switzerland) ', ' PromoCell GmbH (Germany) ', ' Greiner Bio-One International GmbH (Austria) ', ' Avantor, Inc. (US) ', ' Sartorius AG (Germany) ', ' Nano3D Biosciences, Inc. (US) ', ' MIMETAS B.V. (Netherlands) ', ' QGel SA (Switzerland) ', ' TissUse GmbH (Germany) ', ' SynVivo, Inc. (US) ', ' Emulate, Inc. (US) ', ' CN Bio Innovations Ltd. (UK) '

Growing focus on personalized medicine: There is an increasing focus on personalized medicine, which requires the development of patient-specific models for drug testing and disease modeling. 3D cell culture technology can be used to create patient-specific models that can be used for personalized drug discovery and treatment. For instance, Hubrecht Organoid Technology (HUB) has developed a platform that uses patient-derived organoids for drug testing and personalized medicine.

 

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