Global 3D Cell Culture Market Size, Share, Growth Analysis, By Products(Scaffold-Based 3D cell culture, Scaffold-Free 3D cell culture), By Application(Drug Discovery, Tissue Engineering), By End User(Research Laboratories, Institutes), By By Type(hydrogel, ECM) - Industry Forecast 2022-2028

The Global 3D Cell Culture Market is segmented based on Product, Application, End-User, and Region. Based on Product it is categorized into Scaffold-Based 3D cell culture, Scaffold-Free 3D cell culture, Microfluidics, and 3D Bioreactors. Based on Application it is categorized into Cancer Treatment, Stem Cell Research, Drug Discovery, and Regenerative Medicine. Based on End-user it is categorized into Biotechnology & Pharmaceutical Companies, Contract Research Laboratories, and Academic Institutes. Based on type, the market is segmented into hydrogel, ECM, hanging drop, bioreactor, microfluidics, and magnetic levitation. Based on the region it is categorized into North America, Europe, Asia-Pacific, South America, and MEA.

Analysis by Application

Based on application, the analysis of 3D Cell Culture is divided into drug discovery, cancer research, tissue engineering, and regenerative medicine. The cancer research segment ruled the 3D Cell Culture Market with a major revenue share of 24% in 2021. The use of spheroids as a model during the development of anti-cancer treatments pushes R&D in this segment. Furthermore, the use of 3D cellular models for the study of cancer biology in pre-clinical testing, and screening is expected to increase revenue growth in this segment.

A research study reported the progress of polysaccharide hydrogel 3D printed tumor models in January 2021, which can be used for screening of anticancer drugs. The researchers aimed at developing hydrogel, which completely duplicates the tumor microenvironment, showing appropriate biocompatibility, and printability. Such expansions lead to increased use of scaffold-based techniques for cancer.

Stem cell research is likely to record the fastest CAGR from 2022 to 2028. An increase in the use of 3D cell culture platforms for regenerative medicine is expected to push the growth in the segment. Histogen, Inc. engaged in the development of regenerative medicine in January 2020, merged with Conatus Pharmaceuticals Inc. for the final demonstration of a robust channel of unique clinical trials, inclusive of an extracellular matrix scaffold technique for the treatment of conditions related to articular cartilage.

Analysis by End-User

The End-users for 3D cell culture comprised Biotechnology & Pharmaceutical Companies, Contract Research Laboratories, and Academic Institutes. Where the biotechnology and pharmaceutical industries generated a major revenue share of over 46% in 2021. 3D cell cultures are a better fit for drug discovery and development, thereby driving the demand in the forecast period.

Reasons such as the immediate need for rapid and accurate diagnostic services and the advantages of 3D models over 2D models in giving detailed physiological information, boost the hospitals and diagnostic centers growth. Diagnostic centers, such as Kiyatec that are actively involved in giving 3D models for advanced research, are expected to boost the segment growth in the forecast period. Industrial laboratories and Academic institutes are also predicted to contribute to the growing share of this market. Training programs and various workshops on 3D cell culture provided by institutes are expected to drive the demand for 3D cell culture products & systems over the forecast period.

The North American region accounted for the highest revenue share of over 43% and led the global 3D Cell Culture Market in 2021. The region will hold its leading position throughout the forecast period. The availability of private and government funding for the innovation of advanced 3D cell culture models accounts for this growth in the region. High healthcare spending and the presence of numerous universities and research organizations investigating various stem cell-based methods push the growth in the sector. In December 2020, Researchers from Mayo Clinic and Terasaki Institute in the US developed visible hydrogels that can be used for the monitoring and control of hemorrhage.

Asia Pacific is likely to grow at the fastest CAGR in the global 3D cell culture market and is likely to maintain the same trend during the forecast period. This is attainable due to growing investments by several companies and rising healthcare spending in developing economies like China and India in the region. Also, government support & planned initiatives are expected to support the growth of the 3D Cell Culture Market in near future.

Driver

• The United States over the past few years made huge investments in the field of bioengineering, which involves 3D cell culture research too. The National Institute of Health conducted a study in 2020 stating, that the total investment in bio-engineering technologies accounts for USD 5,646, an increase from USD 5,091 in 2019. These factors have increased the US 3D cell culture market.
• There is an expected growth of demand for 3D cell cultures as the demand for organ transplantation is raising in the world. The Canadian Institute for Health study in 2021 shows, that a total of 3,014 transplant procedures were performed in Canada. Which is an increase of 42% since 2010. Therefore, all the above-mentioned factors are expected to boost the 3D Cell Culture Market growth in the region over the forecast period.

Restraint

• The primary factor that hinders the growth of the worldwide 3D cell culture 3D Cell Culture Market consists of the loss of consistency in 3D cell culture products. Researchers face numerous troubles whilst placing scaffold/ECM into microplate wells. This inconsistency in the products reduces the reproducibility of consequences. And thus, reducing the performance of the research.
• Lack of standardization, as well as expensive methods in 3D cell culture, is a major restraint for the market. Furthermore, with rising ethical challenges, it’s difficult to proceed with the experiments and grow at the predicted CAGR.

The global 3D cell culture market is fairly concentrated, with a few big and medium-sized market participants accounting for a large portion of 3D Cell Culture Market revenue. Major players are implementing numerous tactics, including mergers and acquisitions, strategic agreements and contracts, and the development and testing of 3D cell culture platforms.

Top Players' Company Profiles

• 3D Biotek LLC (US)
• Advanced Biomatrix Inc. (US)
• Avantor Inc. (US)
• Becton, Dickinson, and Company (US)
• Corning Incorporated (US)
• Lonza Group (Switzerland)
• InSphero AG (Switzerland)
• Merck & Co., Inc (US)
• Synthecon Inc. (US)
• Thermo Fisher Scientific Inc. (US)

Recent Developments

• In August 2021, Amerigo Scientific has amplified its cell culture selection with the release of 3D cell culture for clinical uses. This new 3D cell culture gadget can utilize in studies regions together with drug discovery, medicine, assessment of nanomaterials, and primary existence science.
• In July 2021, Lonza Group AG (Switzerland) and CN Bio Innovations (UK) partnered to provide pre-validated hepatocytes for use on CN Bio's PhysioMimix Organ-On-a-Chip (OOC) portfolio of single and multi-organ microphysiological systems (MPS).
• In January 2021, Jellagen Limited, a biotechnology enterprise that manufactures high-price Collagen Type zero derived from jellyfish, introduced the release of its JellaGel Hydrogel, a 3D hydrogel. JellaGel gives clients a non-mammalian, natural, biochemically simple, consistent, and smooth to apply hydrogel that could remodel their research.

• The high utility of 3-dimensional models for research on respiratory disorders and Covid-19 is anticipated to provide the market with substantial potential opportunities. Organoids of the airway and air-liquid interface have been employed as experimental virology platforms to research the immune responses and infectivity of SARS-CoV-2 as well as instruments for the development and discovery of antiviral medicines. The biofabrication of realistic models that can be used for the development of novel treatments and vaccines against Covid-19 is made possible by scaffold-based and scaffold-free approaches. The introduction of new goods and widespread use of 3D methods in biological research are a couple of other significant drivers propelling market expansion. For instance, an entirely reusable microplate for 3D cell culture called the EB-Plate was introduced by the Canadian biotechnology business eNUVIO Inc. in December 2020. This is anticipated to boost the usefulness of 3-dimensional microplates, decrease the waste of single-use plastics, and advance the zero-waste movement in laboratories. 

• Similar to RAFT 3D cultures produced by Lonza, typical 2D analytical techniques can be used with ease. Numerous laboratories throughout the world have embraced these revolutionary technologies because they don't call for many modifications to the 2D culture methods that are now in use. In order to advance research on hepatic signalling pathways and drug-induced liver injury and to improve in vitro hepatotoxicity testing, Lonza has also created 3D cell culture models.

SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by the robust Secondary Desk research.

According to our global 3D cell culture market analysis, By application, the cancer research segment is expected to maintain its dominance throughout the forecast period. By the end user, biotechnology and pharmaceutical industries are expected to dominate the 3D Cell Culture Market throughout the forecast period. Furthermore, North America is expected to maintain its dominance throughout the forecast period due to the presence of several pharmaceutical and biotechnology companies that use 3D culture technology in collaboration with research institutes and clinical laboratories to develop regenerative medicines and drug discovery and development. Furthermore, the region's adoption of 3D cell culture procedures is expected to be fueled by an increase in demand for organ transplantation and an increase in R&D efforts centered on technologically advanced solutions.