USD 1.3 billion
Global 3D Cell Culture Market Size, Share, Growth Analysis, By Products(Scaffold-Based, Scaffold-Free), By Application(Cancer Research, Stem Cell Research & Tissue Engineering), By End User(Biotechnology and Pharmaceutical Companies, Academic & Research Institutes) - Industry Forecast 2024-2031
Report ID:
SQMIG35H2246 |
Region:
Global |
Published Date: February, 2024
Pages:
157
|
Tables:
90 |
Figures:
76
Global 3D Cell Culture Market Insights
Global 3D Cell Culture Market size was valued at USD 1.3 billion in 2022 and is poised to grow from USD 1.31 billion in 2023 to USD 11.79 billion by 2031, growing at a CAGR of 18.2% during the forecast period (2024-2031).
3D system electronics have emerged as the basis for drug research, preclinical testing, tissue engineering, and basic sciences, due to their improvement over the traditional technologies. As the cells in the 3D cell culture are allowed to grow and interact in 3D dimensions, the cells can engage with the extracellular matrix which in turn improves the physiological relevance of the cells. While the conventional 2D cultures manage the cells in a flat monolayer, the 3D cultures resemble better the differentiated structures found in vivo. This diversity of 3D cell models includes 3D spheroids, organoids, bioprinted cell models, and organs-on-chips.
The spheroids develop from the cellular growth and aggregation within the 3D culture, possessing a spherical shape as well as maintaining the original cell's genetic composition. Organoids that are produced from stem cells or progenitor cells possess more mature function and a greater degree of complexity. The organs-on-chips that are microfluidic devices are the ones that are structurally like the organs cells and fluid is flowing dynamically in them.
The fast-escalating chronic diseases and medical conditions like multiple organ failures are the major factors behind the high number for organ transplantation. Nevertheless, the scarcity in donors has sparked the exploration for other ways which including regenerative medicine and tissue engineering. 3D cell culture systems are thus enhancing organoid culture and functional tissue constructs development in this way to be later used in tissue transplant and drug response analysis.
In addition, based on the development of new products that are designed to improving the tissue culture and tissue engineering, there is a market is witnessing the introduction of new products. For instance, In June 2023, 3D BioFibR launched two innovative 3D bioprinting collagen fiber products (CollaFibR 3D scaffold and μCollaFibR) in the 3D cell culture capabilities improved. Moreover, a strong demand for in-vitro testing models across various end-user segments, coupled with numerous organic and inorganic initiatives by market participants, is expected to drive market growth.
For Instance, in December 2023, Charles River Laboratories disclosed their partnership with CELLphenomics, aiming to broaden their 3D in vitro services for drug screening applications in cancer therapy.
US 3D Cell Culture Market is poised to grow at a sustainable CAGR for the next forecast year.
Market snapshot - 2024-2031
Global Market Size
Largest Segment
Scaffold-Based
Fastest Growth
Scaffold-Based
Growth Rate
18.2% CAGR
Global 3D Cell Culture Market ($ Bn)
Country Share for North America Region (%)
Global 3D Cell Culture Market By Product ($ Bn)
Global 3D Cell Culture Market By Product (%)
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Global 3D Cell Culture Market Segmental Analysis
Global 3D Cell Culture Market is segmented by Product, Application, End User and region. Based on Product, the market can be segmented into Scaffold-based, Scaffold-free, Bioreactors, and others. Based on Application, the market is segmented into Cancer Research, Stem Cell Research & Tissue Engineering, and Others. Based on End User, the market is segmented into Biotechnology and Pharmaceutical Companies, Academic & Research Institutes, and Others. Based on region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Analysis by Product
The Scaffold-based segment is dominant in the market in 2023, this category is divided into hydrogel, micromatrix base, micropatterned surface microplates, and nanofiber-based scaffolds. The development of the technology can be traced to several reasons such as implementation of scaffold-based cultures in tissue engineering and regenerative medicine, new breakthroughs in scaffold materials manufacturing and fabrication methods, and accomplishing more tasks with research funding and collaborations. Gels like hydrogels are used with cells that bridge the gap between the intrinsic and extrinsic signalling composing the extracellular matrix to a sarcoma of tissue structure. In addition, technology enhances, ongoing research, and recent products launch would continue to compound market penetration. For Instance, in June 2022, Dolomite Bio launched new reagent kits with hydrocool-focused parts for high-throughput cell incubation in hydrogel scaffolding. They joined with ongoing research efforts on the development of scaffold-based technologies. Besides, the extensive research system, including the realization of cell culture printing using a common plant protein by NUS researchers in May 2023, drives the market's growth.
The scaffold-free 3D segment is anticipated to emerge as the fastest growing segment during the forecast period. These are credited to the causes such as enhanced cellular events that increase the throughput and the scalability, the growing need for the personalized medicine, and the progress in 3D culture model platforms and technologies. Additionally, the increasing demand for scaffold-free systems from downstream users like the biopharmaceutical companies and research institutes provides a boost to the market growth.
Analysis by Application
In 2023, the stem cell research & tissue engineering segment accounted for the largest share of the market. However, there is growing evidence that biologics are becoming more dominant, based on the high demand for biopharmaceuticals, including cell and gene therapies, and the improved innovation leading to more approvals. The projections show that the FDA of the USA is planning approximately 10-20 of the cell and gene therapy products approvals per year up to 2025, based on the current clinical success rates and the number of the new therapy drugs in the pipelines. The integration of technology development, government regulations that have been supportive and funding increases for stem-cell research have acted as a catalyst for the utilization of 3D culture models. For instance, in March of 2023, Purdue University's research team was awarded a grant of USD 2.5 million by the National Institutes of Health for the study of stem cells. This funding targets the development of stem cell-based novel therapies, which have great therapeutic potential in many life-threatening diseases.
The cancer research segment is anticipated to show the most rapid CAGR within the estimated period. This expansion is due to the increasing prevalence of cancer and 3D culture models in cancer in research. Moreover, the benefits of 3D media concerning manipulation of cell proliferation and morphology, imaging of phenotypic heterogeneity, and the flexibility they afford also stimulate the market.
Global 3D Cell Culture Market By Product, 2022 (%)
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Global 3D Cell Culture Market Regional Insights
In 2022, North America held the largest share of the market, representing primarily propelled by the growing concentration of universities and research institutions in the region. Additionally, growing government initiatives and funding aimed at developing advanced 3D culture models are expected to further enhance the regional business environment. For Instance, in March 2023, the ALS Society of Canada (ALS Canada) partnered with Brain Canada to invest 1.4 million in supporting nine projects focused on groundbreaking discoveries and treatments for amyotrophic lateral sclerosis (ALS).
The Asia-Pacific market is poised for significant growth, driven by factors such as the increasing disease burden and the widespread adoption of 3D culture by biopharmaceutical industries for drug discovery, aiming to streamline drug development timelines. Additionally, the rising prevalence of diseases like diabetes and obesity further underscores the need for accelerated development of innovative and effective drugs, prompting companies to embrace 3D cell culture technologies. China's 3D cell culture market held the largest share in the region, while India's market emerged as the fastest growing.
Global 3D Cell Culture Market By Region, 2024-2031
- Largest
- Fastest
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Global 3D Cell Culture Market Dynamics
Drivers
Rising power of 3D cell culture in Regenerative medicine improvement
- 3D cell culturing techniques comprising of a novel approach are going to be a new revolution in area of regenerative medicine, which facilitate development of sophisticated tissues structures mimicking natural environment. This ground-breaking innovation enables the investigation of tissue regeneration and engineering at a deeper level which brings it to the forefront of the medical research. Along with regenerative medicine, a new trend in the medical world, these advanced cell culture technologies, like bio-3D, get also more required. Therefore, this emerging technology drives the growth of 3D cell culture industry by providing the technologies which are highly specific for researchers and clinicians for understanding and implementation of regenerative therapies.
Increased healthcare infrastructure investments will promote a precision medicine orientation
- Healthcare organizations are undergoing expansion and renovation activities, which emphasize integration of advanced technologies to improve effectiveness of research and treatment. Moreover, current strategic investment landscapes are promulgating advanced technologies such as 3D cell culture, which are popular for mimicking the physiologically accurate models of drug discovery, disease modelling, and personalized healthcare approaches. Moreover, the increasing prominence of personalized medicine and the mandate for refined models for preclinical screening are compelling reasons for healthcare networks to invest in 3D cell culture technology, which contributes to the growth of the market.
Restraints
Escalating Costs Associated
- The integration of 3D cell cultures represents a leap forward in sophistication compared to conventional monolayer cultures, necessitating the utilization of state-of-the-art cell culture supplies. Consequently, the direct expenses of experiments rise correspondingly. Despite the myriad benefits of 3D cell cultures, their implementation entails higher costs due to the increased expense of 3D scaffolds and materials compared to those used in 2D cell cultures. Particularly in drug discovery endeavors, where a substantial number of experiments are indispensable, the utilization of 3D cell culture methodologies may lead to exorbitant drug development costs, potentially rendering certain avenues financially untenable.
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Global 3D Cell Culture Market Competitive Landscape
The global 3D cell culture market is characterized by intense competition and rapid evolution driven by ongoing innovations and the growing demand for semiconductor devices. Established industry leaders vie for market dominance through product excellence, technical breakthroughs, competitive pricing, and expansive global distribution networks. Sustained investments in research and development, coupled with the adoption of groundbreaking methodologies, serve as pivotal drivers of market leadership.
Top Player’s Company Profile
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Lonza Group AG (Switzerland)
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Becton, Dickinson and Company (US)
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3D Biotek LLC (US)
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InSphero AG (Switzerland)
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Synthecon Inc. (US)
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Tecan Trading AG (Switzerland)
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PromoCell GmbH (Germany)
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Greiner Bio-One International GmbH (Austria)
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Avantor, Inc. (US)
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Sartorius AG (Germany)
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Nano3D Biosciences, Inc. (US)
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MIMETAS B.V. (Netherlands)
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QGel SA (Switzerland)
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TissUse GmbH (Germany)
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SynVivo, Inc. (US)
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Emulate, Inc. (US)
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CN Bio Innovations Ltd. (UK)
Recent Developments
- In September 2023, Curi bio unveiled two new platforms, Nautilus and Stringray, designed to aid researchers in conducting electrophysiology studies on both 2D and 3D cell cultures.
- In July 2023, REPROCELL Inc. partnered with Vernal Biosciences to offer scalable mRNA services for clinical and research purposes in Japan, aligning with REPROCELL’s goal of introducing advanced preclinical and clinical research solutions to the market.
- In July 2023, 3D BioFibR, a Canadian firm, secured a $3.52 million investment to expand its facility and launch collagen fiber products for use in 3D bioprinting.
Global 3D Cell Culture Key Market Trends
- Advanced Cell Culture Technologies: The evolution of organ-on-a-chip and microfluidic systems has surged, offering more sophisticated 3D cell culture environments. These platforms enable researchers to replicate inter-organ and tissue interactions with greater precision. For Instance, in December 2022, Emulate, Inc., introduced the Emulate Chip-A1™ Accessible Chip via an early access initiative. This latest iteration builds upon the foundation of the original Chip-S1, which replicates tissue-vascular interfaces with pertinent biomechanical stimuli like stretch and flow. The Chip-A1™ enables users to cultivate thicker tissues within the epithelial culture chamber and implement a wider array of drug treatment methods, including topical or aerosolized applications, thereby enhancing versatility and experimentation options..
Global 3D Cell Culture Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Component types team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
According to our analysis, the 3D cell culture market is experiencing robust growth driven by increasing applications across various research fields such as regenerative medicine, drug discovery, and toxicology studies. The demand for more physiologically relevant cell culture models that closely mimic native tissue environments is fuelling market expansion. Technological advancements, particularly in organ-on-a-chip and microfluidic systems, are enabling researchers to create complex 3D cell culture environments with greater accuracy, facilitating the study of tissue interactions and disease mechanisms. Moreover, rising investments in healthcare infrastructure and a growing emphasis on precision medicine are further propelling the adoption of 3D cell culture technologies. Key market players are focusing on product innovation, strategic partnerships, and acquisitions to maintain their competitive edge in this dynamic landscape.
| Report Metric | Details |
|---|---|
| Market size value in 2022 | USD 1.3 billion |
| Market size value in 2031 | USD 11.79 billion |
| Growth Rate | 18.2% |
| Base year | 2023 |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
|
| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Global 3D Cell Culture Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Global 3D Cell Culture Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Global 3D Cell Culture Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Global 3D Cell Culture Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Global 3D Cell Culture Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Global 3D Cell Culture Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
Global 3D Cell Culture Market Report Snapshots
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