USD 1.12 billion
Report ID: SQMIG35G2036 | Region: Global | Published Date: April, 2023 | Pages: 157 | Tables: 126 | Figures: 77
Global 3D Cell Culture Market size was valued at USD 1.12 billion in 2021 and is poised to grow from USD 1.3 billion in 2022 to USD 4.77 billion by 2030, growing at a CAGR of 15.6% in the forecast period (2023-2030).
The global 3D cell culture market is experiencing significant growth, driven by various factors. One key driver is the increasing efforts to develop alternatives to animal-based testing and the availability of funding programs for research. With concerns over the limitations of animal models in cellular-based studies, government organizations are promoting alternative methods for drug development. Additionally, biopharmaceutical companies' consistent focus on R&D activities for drug discovery and development, along with the adoption of 3D cell cultures in cancer research, further fuels market growth.
The rising burden of chronic diseases and the need for organ transplants have led to a demand for alternative solutions such as regenerative medicine and tissue engineering. 3D cell culture systems play a crucial role in nurturing organoids and tissue constructs for transplantation and drug response analysis. Recent product launches with improved mimicry of human body conditions support market growth.
Partnerships between pharmaceutical companies, academic institutions, and research institutes contribute to the advancement of 3D cell culture technology. Collaboration accelerates technology development, knowledge sharing, and protocol standardization, leading to increased adoption of 3D cell culture techniques. Supportive government legislation and funding from public and private organizations further drive R&D activities in the market. The robust demand for in-vitro testing models, along with organic and inorganic initiatives by market players, also facilitates market expansion. Collaborations between companies, such as the strategic collaboration between zPREDICTA, Inc. and LabCorp, and the collaboration between Merck and D1 Med, accelerate the adoption of 3D cell cultures in drug research and development. These factors collectively contribute to the growth and expansion of the global 3D cell culture market.
US 3D Cell Culture Market is poised to grow at a sustainable CAGR for the next forecast year.
Global Market Size
USD 1.12 billion
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Global 3D Cell Culture Market is segmented on the basis of technology, application, end user, and region. By technology, the market is segmented into scaffold-based, scaffold-free, bioreactors, microfluidics, and bioprinting. By application, the market is segmented into Cancer research, stem cell research and tissue engineering, drug development and toxicity testing, and others. By end user, the market is segmented into biotechnology and pharmaceutical companies, academic and research institutes, hospitals, and others. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Analysis By Technology
The scaffold-based technology segment is the largest segment of the global 3D cell culture market, accounting for 48.85% of the market share in 2022. This segment is expected to experience significant growth during 2023-2030 due to various factors such as increasing applications of scaffold-based cultures in tissue engineering and regenerative medicine, advancements in scaffold materials and fabrication techniques, and increasing research funding and collaboration. Hydrogels are increasingly being used as a scaffold in cell-based studies as they allow the incorporation of biochemical and mechanical signals that mimic the native extracellular matrix. Furthermore, ongoing research efforts to develop scaffold-based technologies are another factor supporting market expansion. For example, Dolomite Bio launched novel hydrogel-focused reagent kits for high-throughput encapsulation of cells in hydrogel scaffold in July 2022. Moreover, in May 2023, researchers from NUS successfully used a common plant protein to 3D print an edible cell culture scaffold.
The scaffold-free segment is expected to witness the fastest growth at a CAGR of 18.15% during the forecast period due to factors such as enhanced cellular interactions, higher throughput, and scalability, rising demand for personalized medicine, and advancements in 3D cell culture platforms and technologies. The biopharmaceutical industry and research institutes are among the key end-users driving the demand for scaffold-free systems.
Analysis By End User
The biotechnology and pharmaceutical companies segment dominated the global 3D cell culture market, accounting for 46.34% of the market share in 2022. The growth and commercial success of biopharmaceuticals and the ability of major pharmaceutical companies to leverage their portfolios have contributed to the segment's growth. 3D cell culture offers several benefits such as optimal oxygen and nutrient gradient formation and realistic cellular interactions, making it an ideal method for drug discovery and development.
On the other hand, the academic and research institutes segment is expected to register the fastest CAGR of 17.39% during 2023-2030. This can be attributed to factors such as advancements in biomedical research, increasing research activities, rising industry-academia collaboration, and significant efforts from research institutions in drug modelling and drug screening. These factors are anticipated to accelerate the growth of this segment.
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North America held the largest market share of 45.58% in 2022. This was due to factors such as advanced healthcare infrastructure, developed economies, the presence of key players, and strategic initiatives undertaken by them. Additionally, a supportive regulatory framework, government support for the development of three-dimensional culture models, and numerous research organizations and universities investigating different stem-cell based approaches are expected to further boost the regional market. For instance, the Harvard Stem Cell Institute is utilizing stem cells to revolutionize medicine for better outcomes.
The Asia Pacific region is projected to experience the highest Compound Annual Growth Rate (CAGR) of 19.74% during 2023-2030. This can be attributed to the high burden of chronic diseases, a thriving biotechnology sector, lower operating costs, and increased investments by companies in the region. Furthermore, the rising demand for cellular therapies, growing biobanks, and strong research potential are also contributing to the regional market's growth.
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Growing demand for organ transplantation
The increasing prevalence of chronic diseases, such as diabetes and kidney failure, has led to a rise in demand for organ transplantation. However, there is a shortage of organs available for transplantation. 3D cell culture technology can be used to develop functional organs for transplantation, which is driving the growth of the market. For example, Organovo, a biotechnology company, has developed 3D printed liver tissues for use in drug testing and transplantation research.
The use of 3D cell culture technology in research has raised ethical concerns related to the use of human cells and tissues. This has led to regulatory hurdles that could impede the growth of the market.
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The global 3D cell culture market is highly competitive with the presence of several major players. Some of the key players in the market are focusing on product innovation, partnerships, collaborations, and mergers and acquisitions to expand their market presence. For example, in 2021, Corning Incorporated acquired Falcon Genomics to expand its portfolio of 3D cell culture products. Similarly, InSphero AG partnered with Roche to develop 3D cell-based assays for drug discovery and development. The market is expected to witness further consolidation as companies aim to gain a competitive edge by expanding their product portfolios and enhancing their technological capabilities.
Top Player’s Company Profile
Lonza Group AG (Switzerland)
Becton, Dickinson and Company (US)
3D Biotek LLC (US)
InSphero AG (Switzerland)
Synthecon Inc. (US)
Tecan Trading AG (Switzerland)
PromoCell GmbH (Germany)
Greiner Bio-One International GmbH (Austria)
Avantor, Inc. (US)
Sartorius AG (Germany)
Nano3D Biosciences, Inc. (US)
MIMETAS B.V. (Netherlands)
QGel SA (Switzerland)
TissUse GmbH (Germany)
SynVivo, Inc. (US)
Emulate, Inc. (US)
CN Bio Innovations Ltd. (UK)
In October 2022, Corning introduced the Elplasia 12K flask, a unique microcavity geometry that simplifies spheroid formation, culture, treatment, assessment, and harvest. The flask produces around 12,000 spheroids of consistent size and shape per flask, resulting in a 125-fold greater yield than traditional 96-well spheroid plates.
In March 2021, Thermo Fisher Scientific launched a plasma-like medium that imitates the metabolic profile of human plasma. This cell culture medium was created to provide researchers with an accurate representation of cell growth within the human body. This novel product offers researchers an advanced tool for studying cell behavior in vitro.
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According to our Global 3D Cell Culture Market analyses, the global 3D cell culture market is expected to experience significant growth in the coming years due to factors such as the increasing demand for organ transplantation, advancements in technology, and the growing focus on personalized medicine. Additionally, the market is being driven by the rising prevalence of chronic diseases, the growing biotechnology sector, and increasing investments by companies in the Asia Pacific region. However, high costs associated with 3D cell culture systems and ethical concerns related to the use of human cells and tissues are expected to restrain market growth. The market is highly competitive, with major players focusing on product innovation, partnerships, and mergers and acquisitions to expand their market presence.
|Market size value in 2021||USD 1.12 billion|
|Market size value in 2030||USD 1.3 billion|
|Forecast Unit (Value)||USD Billion|
|Regions covered||North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA)|
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Parent Market Analysis
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MARKET DYNAMICS & OUTLOOK
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For the Global 3D Cell Culture Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Global 3D Cell Culture Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
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The Asia Pacific region is expected to show the fastest growth in coming years. As the major investments by key market players in india and china are propelling the growth of the market in following region.
The two largest end user segments are pharmaceutical and biotechnology. They both together account for 43.8% share of the 3D cell culture market.
3D cell culture is a technique used in cell biology to grow and study cells in a three-dimensional environment that more closely mimics the natural environment of cells in living organisms. This method involves growing cells on a scaffold or in a hydrogel matrix that provides structural support and allows for the formation of complex cell-to-cell interactions. 3D cell culture has become increasingly popular in drug discovery and tissue engineering due to its ability to better predict how cells will behave in vivo.
There are several examples of 3D cell culture techniques, such as spheroids, organoids, and tissue engineering. Spheroids are spherical clusters of cells that can be used to study tumor growth and drug response. Organoids are 3D structures that mimic the structure and function of organs, such as the liver and intestine. Tissue engineering involves growing cells on a scaffold to create functional tissues, such as skin and bone, for transplantation.
3D cell cultures can be made using various methods, such as scaffold-based and scaffold-free techniques. Scaffold-based methods involve growing cells on a 3D scaffold made of natural or synthetic materials, such as hydrogels or extracellular matrices. Scaffold-free methods, such as hanging drop and magnetic levitation, do not require a scaffold and instead rely on the self-assembly of cells to form 3D structures. The choice of method depends on the specific application and the type of cells being cultured.
3D cell culture tissue models are complex 3D structures that mimic the structure and function of tissues in living organisms. These models are created by growing cells on a scaffold or in a hydrogel matrix that provides structural support and allows for the formation of complex cell-to-cell interactions. 3D tissue models have become increasingly popular in drug discovery and toxicity testing due to their ability to better predict how drugs and chemicals will behave in vivo.
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