Top 3D Cell Culture Companies

The growing demand for physiologically relevant models in drug discovery is a primary driver of the global 3D cell culture market. Traditional 2D cultures fail to replicate the complex in vivo environment, leading to inaccurate predictions of drug efficacy and toxicity. In contrast, 3D cells cultures better mimic human tissue architecture, enabling more reliable preclinical testing. This has encouraged pharmaceutical and biotechnology companies to adopt 3D systems for screening, disease modeling, and personalized medicine, ultimately reducing drug development costs and improving clinical translation success rates.

Industry Overview

According to SkyQuest Technology “Global 3D Cell Culture Market” By Product Type (Scaffold-based 3D Cell Cultures, Scaffold-free 3D Cell Cultures), By Application (Cancer Research & Stem Cell Research, Drug Discovery & Toxicology Testing), By End User, By Region - Industry Forecast 2025-2032,” Global 3D cell culture market is projected to grow at a CAGR of over 12.3% by 2032, on account of urgent need for automating quantified data. Continuous innovations in scaffold-based 3D culture technologies act as a key growth factor for the market. These advancements enable precise control over cell–matrix interactions, nutrient diffusion, and tissue organization.

Top 10 Global 3D Cell Culture Companies

1. Corning Incorporated

Corning Incorporated is a global leader in materials science and glass technology, renowned for its innovations that transform industries and enhance everyday life. Founded in 1851 and headquartered in Corning, New York, the company operates across multiple sectors, including life sciences, telecommunications, display technologies, and specialty materials. Its Life Sciences division provides advanced laboratory consumables, 3D cell culture solutions, and bioprocessing tools supporting global research and healthcare innovation. Recent developments include expanding its 3D cell culture product line and strengthening collaborations in biomanufacturing to accelerate breakthroughs in drug discovery and regenerative medicine.

2. Thermo Fisher Scientific

Thermo Fisher Scientific is a global leader in scientific research services, providing innovative solutions that enable life sciences, healthcare, and applied science advancements worldwide. Founded in 2006 through the merger of Thermo Electron and Fisher Scientific, the company is headquartered in Waltham, Massachusetts. Its extensive portfolio includes laboratory instruments, analytical equipment, reagents, consumables, and advanced 3D cell culture technologies. Thermo Fisher serves pharmaceutical, biotechnology, academic, and clinical sectors with integrated R&D and manufacturing services. Recently, the company has expanded its bioproduction capabilities and digital lab platforms to accelerate drug discovery and personalized medicine initiatives globally.

3. Merck KGaA

Merck KGaA is a leading global science and technology company driving innovation across healthcare, life science, and electronics. Founded in 1668 and headquartered in Darmstadt, Germany, it is one of the world’s oldest operating pharmaceutical and chemical enterprises. The company’s Life Science division, operating as MilliporeSigma in the U.S. and Canada, provides cutting-edge laboratory materials, reagents, and 3D cell culture solutions such as Matrigel® for drug discovery and biomanufacturing. Recently, Merck KGaA has expanded its bioprocessing and cell engineering capabilities to support regenerative medicine and advanced therapeutic research worldwide.

4. Lonza Group

Lonza Group is a leading global provider of integrated healthcare solutions, specializing in biopharmaceutical manufacturing and life science innovation. Founded in 1897 and headquartered in Basel, Switzerland, the company offers a broad portfolio that includes cell and gene therapy development, biologics manufacturing, and 3D cell culture systems. Lonza partners with pharmaceutical and biotechnology companies to accelerate drug discovery and production through scalable, high-quality bioprocessing solutions. Recently, the company has expanded its global manufacturing network and invested in advanced cell and gene therapy platforms to enhance personalized medicine and regenerative therapy capabilities worldwide.

5. Sartorius AG

Sartorius AG is a leading international partner of the biopharmaceutical industry and research laboratories, specializing in advanced bioprocessing and laboratory technologies. Founded in 1870 and headquartered in Göttingen, Germany, the company provides innovative solutions that enable the efficient development and manufacture of biotech drugs. Its core offerings include single-use bioreactors, filtration systems, cell culture media, and 3D cell expansion technologies. Sartorius supports global life science research through precision instruments and digital lab solutions. Recently, it has focused on expanding automation and data analytics capabilities to accelerate biologics development and streamline production workflows.

6. STEMCELL Technologies

STEMCELL Technologies is a leading biotechnology company dedicated to advancing scientific discovery through innovative cell culture products and research solutions. Founded in 1993 and headquartered in Vancouver, Canada, the company specializes in high-quality reagents, media, and tools that support stem cell research, immunology, and regenerative medicine. Its portfolio includes specialized 3D cell culture systems and organoid models that closely replicate human tissue biology. STEMCELL Technologies partners with global research institutions to enhance reproducibility and scientific progress. Recently, it has expanded manufacturing capacity and launched advanced organoid culture platforms to accelerate breakthroughs in personalized and disease-modeling research.

7. InSphero AG

InSphero AG is a pioneering biotechnology company specializing in 3D cell culture technologies and organ-on-a-chip solutions for drug discovery and safety testing. Founded in 2009 and headquartered in Schlieren, Switzerland, the company develops highly functional 3D microtissues that closely mimic human organ physiology, enabling more predictive preclinical testing. Its key offerings include liver, pancreas, and tumor models used in toxicology, metabolic disease, and oncology research. InSphero collaborates with major pharmaceutical companies to enhance drug development accuracy. Recently, it has expanded its organ-on-a-chip platform to support next-generation precision medicine and toxicity prediction initiatives globally.

8. MIMETAS

MIMETAS is a leading biotechnology company specializing in organ-on-a-chip technology and 3D tissue modeling for advanced drug discovery and toxicology research. Founded in 2013 and headquartered in Oegstgeest, Netherlands, the company develops microfluidic platforms that replicate human organ function with high precision. Its flagship product, the OrganoPlate®, enables scalable, high-throughput 3D culture and perfusion-based assays for more accurate biological insights. MIMETAS partners with global pharmaceutical companies to improve drug efficacy and safety prediction. Recently, it has expanded its disease modeling and stem cell-derived organoid platforms to accelerate personalized and regenerative medicine research worldwide.

9. Organovo Holdings, Inc.

Organovo Holdings, Inc. is a biotechnology company at the forefront of 3D bioprinting and human tissue engineering for medical research and therapeutic applications. Founded in 2007 and headquartered in San Diego, California, the company develops functional, 3D bioprinted human tissues that closely mimic native organ structures. These models are used in drug discovery, disease modeling, and preclinical testing to improve the prediction of human responses. Organovo collaborates with pharmaceutical and academic partners to advance tissue-based therapies. Recently, the company has expanded its focus on liver and kidney tissue programs to support regenerative medicine and drug toxicity research.

10. BICO (CELLINK)

BICO (formerly CELLINK) is a global bioconvergence company revolutionizing the fields of bioprinting, life sciences, and healthcare technology. Founded in 2016 and headquartered in Gothenburg, Sweden, BICO integrates biology, engineering, and digital innovation to enable the creation of human tissues and organ models. Its portfolio includes advanced 3D bioprinters, bioinks, laboratory automation systems, and cell culture technologies that accelerate research in regenerative medicine and drug discovery. Recently, BICO has strengthened its presence in biomanufacturing through strategic acquisitions and partnerships, driving innovation toward sustainable, personalized, and automated life science solutions worldwide.

Other Leading Global 3D Cell Culture Companies

• Advanced BioMatrix
• Greiner Bio-One
• PromoCell GmbH
• AMSBIO
• Eppendorf SE
• Axion BioSystems
• MatTek Corporation
• Bio-Rad Laboratories, Inc.
• BD (Becton, Dickinson and Company)
• Takara Bio Inc.

Conclusion

The global 3D cell culture market is undergoing a transformative phase driven by technological innovation, rising pharmaceutical investments, and the growing need for physiologically relevant research models. As drug discovery becomes increasingly complex, 3D systems provide more accurate biological insights, reducing development costs and improving clinical outcomes. Leading companies such as Corning, Thermo Fisher Scientific, and Merck KGaA are advancing biomaterials, scaffolds, and bioprinting technologies to replicate human tissue behavior. With continuous innovation and strong industry collaborations, the 3D cell culture market is poised to revolutionize regenerative medicine, personalized therapies, and predictive toxicology research worldwide.