USD 400.5 million
Report ID:
SQMIG35H2045 |
Region:
Global |
Published Date: February, 2024
Pages:
157
|Tables:
121
|Figures:
78
Targeted Protein Degradation Market size was valued at USD 507 million in 2022 and is poised to grow from USD 640.85 million in 2023 to USD 4175.72 million by 2031, growing at a CAGR of 26.40% in the forecast period (2024-2031).
Targeted Protein Degradation is becoming popular since It is a relatively new approach to drug development that involves using small molecules to selectively eliminate disease causing proteins. It is considered that this approach has several advantages over traditional drug development methods. These advantages include broad applicability, greater selectivity, increased durability, potential for combination therapy, novel mode of action.
Targeted protein degradation is a cutting-edge approach to drug development that offers several potential advantages over conventional methods. One of the key advantages of targeted protein degradation is its broad applicability, allowing it to target a wide range of disease-causing proteins. This includes proteins that have previously been considered "undruggable" using traditional methods. The ability to target a wider range of proteins offers potential new treatments for a variety of diseases, including cancer and genetic disorders. By selectively degrading the specific proteins that cause disease, targeted protein degradation can potentially provide a more effective and specific treatment compared to traditional methods that target entire cells or tissues.
Moreover, the selectivity of targeted protein degradation is a significant advantage. Unlike traditional drugs that can have non-specific effects on cells or tissues, targeted protein degradation can specifically degrade only disease-causing proteins without affecting normal proteins. This reduces the risk of side effects and improves therapeutic efficacy. Another potential advantage of targeted protein degradation is the increased durability of the treatment. Targeted protein degraders can remain active in the body for longer periods of time than traditional drugs, resulting in prolonged therapeutic effects. This may reduce the frequency of dosing, improve patient compliance, and ultimately lead to better patient outcomes.
US Targeted Protein Degradation Market is poised to grow at a sustainable CAGR for the next forecast year.
Global Market Size
USD 400.5 million
Largest Segment
PROTACs (Proteolysis targeting chimeras.)
Fastest Growth
Molecular glues.
Growth Rate
26.4% CAGR
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Global Targeted Protein Degradation market is segmented on the basis of application, Technology, therapeutic area, indication, and region. By end use application, the market is segmented into Small Molecule drug discovery, protein discovery, research applications, and others. By Technology, the market is segmented into PROTACs (Proteolysis-Targeting Chimeras), LYTACs (Lysosome-Targeting Chimeras), and SNIPERs (Specific and Non-genetic IAP-dependent Protein ERasers), Molecular glues, and others. By therapeutic area, the market is segmented into oncology, immunology, genetic disorders, and other diseases. By indication, the market is segmented into breast cancer, lung cancer, leukemia, solid tumors, and others. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Targeted Protein Degradation Market Analysis by Technology
By Technology, the global market is divided into many segments such as PROTACs (Proteolysis-Targeting Chimeras), LYTACs (Lysosome-Targeting Chimeras), and SNIPERs (Specific and Non-genetic IAP-dependent Protein ERasers), Molecular glues, and others. The targeted protein degradation market is currently dominated by PROTACs (Proteolysis-Targeting Chimeras) in terms of technology. PROTACs are small molecules that can recruit target proteins to E3 ubiquitin ligases, which then catalyze the ubiquitination and subsequent degradation of the target protein by the proteasome. PROTACs have gained significant attention in recent years due to their potential for selectively targeting disease-causing proteins, including those previously considered "undruggable" using traditional methods. As a result, many pharmaceutical companies are heavily investing in PROTAC research and development, driving the growth of the market.
The targeted protein degradation market is currently witnessing the fastest growth in the molecular glues technology segment. Unlike other targeted protein degradation technologies, such as PROTACs and molecular degraders, molecular glues utilize a simpler chemical structure to bring together a target protein and an E3 ubiquitin ligase, thereby promoting the ubiquitination and subsequent degradation of the target protein.Molecular glues have several advantages over other targeted protein degradation technologies, including their ability to degrade targets that are difficult to access using other methods. Recently, several companies have made significant advancements in molecular glue technology, which has attracted significant attention and investment in the field. As a result, the molecular glues segment is expected to experience rapid growth in the coming years.
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The targeted protein degradation market is currently dominated by North America, which holds the largest market share. This is attributed to the presence of numerous pharmaceutical and biotechnology companies in the region, as well as substantial investment in research and development activities.
However, the Asia Pacific region is anticipated to witness the highest growth rate in the targeted protein degradation market. The growth can be attributed to the rising investment in healthcare infrastructure and research and development in countries such as China, Japan, and India. Moreover, the region has a vast population with high unmet medical needs, which is driving the demand for novel therapies, including targeted protein degradation.
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Targeted Protein Degradation Market Drivers
Increasing Demand for Effective Cancer Treatment to Boost Market Growth
Targeted Protein Degradation Market Restraints
Complexity of Targeted Protein Degradation to Hinder Market Growth
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It is considered that the competition within the global Targeted Protein Degradation market will intensify during the forecast period. This can be attributed to the entry of new players into the market and the increasing number of developments that are compatible with Targeted Protein Degradation. Presently, only a few major players are operating within the global market. However, this scenario is expected to change in the forthcoming years as more companies are likely to enter the market and offer their services.As the potential of Targeted Protein Degradation for the development of effective therapies for various diseases is becoming increasingly evident, there is a growing interest in this field. This has led to the entry of new players into the market, ranging from small startups to large pharmaceutical companies. With the increasing investments being made in research and development activities, more companies are expected to enter the market and offer their services, resulting in an intensified competitive landscape. Moreover, the growing number of developments compatible with Targeted Protein Degradation is expected to further increase the competition in the market. As more discoveries are made regarding the efficacy of this approach, it is expected to attract more companies, researchers, and investors to this field, thereby increasing the competition.
Targeted Protein Degradation Market Top Player’s Company Profiles
Targeted Protein Degradation Market Recent Developments
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates and Analyses the Data collected by means of Primary Exploratory Research backed by the robust Secondary Desk research.
Our analysis of the global market for targeted protein degradation indicates that this field is poised for significant growth during the forecast period, owing to several advantages it offers over traditional drug development approaches. For instance, targeted protein degradation has broad applicability and can be used to target a wide range of disease-causing proteins, including those that were previously considered "undruggable". This approach also provides greater selectivity and increased durability, which could result in more effective treatments with fewer side effects. Moreover, targeted protein degradation offers the potential for combination therapy, which is increasingly being recognized as a promising approach to treating complex diseases such as cancer. Additionally, the novel mode of action of targeted protein degradation makes it an attractive area of research for drug developers. Furthermore, the use of targeted protein degradation can improve the convenience and efficacy of oral drugs, as well as other investments for effective treatments. With the high expected rate of growth and demand, the targeted protein degradation market offers significant potential for new players to enter the market and contribute to its growth.
Report Metric | Details |
---|---|
Market size value in 2022 | USD 507 million |
Market size value in 2031 | USD 4175.72 million |
Growth Rate | 26.40% |
Base year | 2023 |
Forecast period | 2024-2031 |
Forecast Unit (Value) | USD Million |
Segments covered |
|
Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
Companies covered |
Targeted Protein Degradation Market Recent Developments
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Executive Summary
Market overview
Parent Market Analysis
Market overview
Market size
KEY MARKET INSIGHTS
COVID IMPACT
MARKET DYNAMICS & OUTLOOK
Market Size by Region
KEY COMPANY PROFILES
For the Targeted Protein Degradation Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Targeted Protein Degradation Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
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Report ID: SQMIG35H2045