USD 28.50 billion
Global Plasma Fractionation Market Size, Share, Growth Analysis, By Product(Albumin, Immunoglobulins), By Method(Centrifugation, Depth Filtration), By Application(Neurology, Hematology), By End Use(Hospitals & Clinics, Clinical Research and Others) - Industry Forecast 2023-2030
Report ID: SQMIG35H2165 | Region: Global | Published Date: July, 2023 | Pages: 157 | Tables: 119 | Figures: 77
Global Plasma Fractionation Market Insights
Global Plasma Fractionation Market size was valued at around 28.50 billion in 2021 and is expected to rise from USD 30.87 billion in 2022 to reach a value of USD 58.24 billion by 2030, at a CAGR of 8.3 % over the forecast period (2023-2030).
Convalescent plasma was in greater demand during COVID-19 because doctors used it to treat the virus-infected patients at first. For instance, convalescent plasma was used extensively internationally to treat patients hospitalized with coronavirus and stop the progression of the disease, according to a Frontiers paper from June 2021. Convalescent plasma transfusion has been linked to better symptomatology and virus clearance, according to studies. As a result, plasma fractions were originally needed in increasing amounts to treat the COVID-19 patient. The analyzed market is anticipated to have steady expansion throughout the course of the study's prediction period as the epidemic has faded and fewer people are becoming infected with the virus.
The increasing use of immunoglobulins in various therapeutic fields, the expanding elderly population along with the rising prevalence of uncommon diseases, and the rising number of plasma collection facilities globally are some of the specific factors driving the market expansion. For instance, the percentage of people in the world over 60 will nearly treble by 2050, according to WHO statistics from October 2022. The old population of the globe is expected to age far more quickly than in the past by 2050, with 80% of them living in low- and middle-income nations. As a result, the burden of uncommon diseases is predicted to rise globally along with the aging population, raising the demand for plasma fractionation products and propelling the development of the market under investigation.
Furthermore, 1% of the world's population is thought to be affected with Von Willebrand's disease, according to an article updated by NCBI in August 2022. However, the prevalence of clinically important diseases is still thought to be around 125 per million, with severe diseases affecting up to 5 per million. Therefore, it is projected that the growing elderly population together with the burden of uncommon diseases like Von Willebrand will drive demand for plasma fractionation products, thereby promoting market growth. Additionally, the expansion of plasma collecting facilities across the globe is a key element in the development of the market under investigation. For instance, Bio Products Laboratory Ltd (BPL), a top producer of medicines using plasma-derived proteins, inaugurated its 29th plasma donation facility in April 2022. Additionally, Freedom Plasma established its fourth plasma donation facility in Ohio, US, in October 2022. Thus, expanding the number of plasma centers globally is anticipated to boost the manufacturing of plasma-based goods and consequently, market growth.
The market is also expected to grow as a result of numerous initiatives taken by the major market players, including product launches, alliances, mergers, and acquisitions, to introduce cutting-edge plasma fractionation methods and products to the marketplace. For instance, Octapharma was given permission to increase the use of cutaquig in the European Union (EU) in January 2022. Human immunoglobulin called Cutaquig is administered subcutaneously. It offers numerous patients with inherited immune deficiency flexible therapeutic options. The rising geriatric population coupled with an increase in the prevalence of rare diseases, the rising number of plasma collection centers, and various initiatives by the major market players are all predicted to have a positive impact on the market during the forecast period. The industry under study is constrained, though, by stringent laws governing the processing of plasma protein products, high prices, and problems with reimbursement.
Market snapshot - 2023-2030
Global Market Size
Largest Segment
Immunoglobulins
Fastest Growth
Immunoglobulins
Growth Rate
8.3% CAGR
Global Plasma Fractionation Market 2022-2030 ($ Bn)
Country Share for North America Region- 2022 (%)
Global Plasma Fractionation Market By Product 2022-2030 ($ Bn)
Global Plasma Fractionation Market By Product 2022-2030 (%)
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Global Plasma Fractionation Market Segmental Analysis
The global plasma fractionation market is segmented based on product, method, application, end use, and region. Based on product, the market is segmented into albumin, immunoglobulins, coagulation factors, protease inhibitors. In terms of method, the market is segmented into centrifugation, depth filtration, and chromatography. With respect to segmentation by application, the market is segmented into neurology, hematology, oncology, immunology, and pulmonology. On the basis of categorization by end use, the market is segmented into hospitals & clinics, clinical research, and others. Regionwise, the global plasma fractionation market is widespread into North America, Europe, Asia-Pacific, South America, and MEA.
Global Plasma Fractionation Market Analysis by Product
Immunoglobulin segment earned the dominant share as it is being used for the treatment, diagnosis, and administration of metabolic disorders, which is one of the major causes fueling the segment’s expansion. Immunoglobulin will therefore gain from extensive use, increasing its market share and potential.
The market for plasma fractionation is also growing due to reasons such as the approval of new drugs, the prevalence of bleeding disorders, and growing programmes & donating for patients with severe bleeding disorders like hemophilia. For instance, Grifols International SA, a provider of plasma-derived pharmaceuticals, provided blood clotting factor medications (100 million international units) for the treatment of hemophilia patients in April 2019 as part of a long-term programme to support persons with hemophilia.
Global Plasma Fractionation Market Analysis by Application
The neurology category dominated the global market in 2022 with USD 8,356.9 revenue. The global rise in neurological disease incidence is one of the primary drivers of market expansion. For instance, the Centers for Disease Control and Prevention estimates that 795,000 Americans experience a stroke each year. Additionally, the aging population poses a threat to the prevalence of neurovascular illnesses like stroke. Beyond the age of 55, the risk of having a stroke doubles, which encourages the use of plasma-based products for therapy and boosts market expansion.
On the other hand, during the anticipated time, the oncology area displays the fastest rate. With the potential for metastasis and drug resistance, demanding targets that were previously untreatable are now being addressed by an increasing array of plasma treatments for cancer. Additionally, a thorough examination of the complex effects of cold atmospheric plasma in cancer treatment is necessary to go towards the drug's widespread clinical adoption, which supports the segment's expansion.
Global Plasma Fractionation Market By Product 2022 (%), 2021 (%)
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Global Plasma Fractionation Market Regional Insights
North America has a 53.93% share of the regional market, dominating it. This is a result of both an increase in the prevalence of respiratory illnesses and growing knowledge of the many benefits of plasma among North American citizens. The expansion of the regional market is further aided by the existence of key players, an increase in the quantity of plasma collection facilities, a rise in the consumption of plasma collections and distribution of immunoglobulin, and the availability of plasma.
Asia Pacific is expanding as a result of tighter government regulations, favorable public and private funding for R&D, increased antibody usage, rising incidence of targeted illnesses among older people in blood-related diseases, and rising acceptance of plasma-based treatments.
Global Plasma Fractionation Market By Geography, 2022-2030, 2023-2030
- Largest
- Fastest
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Global Plasma Fractionation Market Dynamics
Global Plasma Fractionation Market Drivers
Growing Aging Population
- The aging population is another major driver of the plasma fractionation market. As people age, they are more likely to develop chronic diseases and require medical treatments, including plasma-derived products.
Respiratory illnesses and AATD are becoming more prevalent
- Protease inhibitors like alpha-1-antitrypsin have been increasingly popular in recent years for the treatment of hepatic and lung conditions such cirrhosis, fibrosis, and inflammation of the liver. Undiagnosed and persistent, alpha-1-antitrypsin deficiency (AATD) is a hereditary metabolic condition. In the US, it causes 2-3% of emphysema cases. Alpha-1-antitrypsin deficiency causes pan-lobular emphysema to develop early in smokers and non-smokers, while aberrant alpha-1-antitrypsin buildup in the liver causes illnesses. AATD happens everywhere, but the prevalence varies by region. Chronic obstructive pulmonary disease (COPD), which also includes emphysema and chronic bronchitis, is referred to as this condition. A large number of instances of COPD are linked to severe AATD. The prevalence of the PI*ZZ Alpha-1 Antitrypsin genotype in people with COPD was reported to be roughly 50% in Europe, 37% in America, 9% in Asia, 3% in Australasia, and 1% in Africa, according to a published by Elsevier B.V. in July 2023. In persons over 40, the estimated crude prevalence of COPD was 13.51% in the United States, 12.45% in Europe, 13.22% in Africa, 11.70% in Asia, and 11.86% in Australasia. Prevalence was found to be much lower in parts of Asia and Africa, but significantly greater in Europe, the USA, Canada, New Zealand, and Australia.
- The number of persons receiving treatments for AATD and emphysema is anticipated to rise as a result of the increasing frequency of these diseases and advancements in diagnostic methods like CT scanning. In turn, this will increase demand for protease inhibitors like alpha-1-antitrypsin and support the market growth for plasma fractionation as a whole.
Global Plasma Fractionation Market Restraints
High Cost of Plasma Fractionation Products
- The high cost of plasma fractionation products is a major restraint on market growth. These products are expensive to manufacture, which can make them unaffordable for some patients and healthcare systems.
Recombinant substitutes' impact on the market
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Companies in this market segment should benefit financially from recent approvals for recombinant factors such AFSTYLA (CSL), VONVENDI (Takeda/Shire), and Kovaltry (Bayer). Standard half-life products and extended half-life products are the two groups of recombinant factor products that are currently offered. The first group of recombinant factors remain in the body for the same amount of time as factor VIII or factor IX found in nature. Extended half-life products, on the other hand, have been changed to last longer in the body than conventional half-life products. Recombinant factors VIII and IX have become more popular in industrialized nations as alternatives to plasma-derived factors VIII and IX in the treatment of bleeding disorders, according to the results of the World Federation of Hemophilia's (WFH) 2020 Annual Global Survey. Recombinant factors, on the other hand, are now being used more frequently in nations like Brazil, India, and Russia. This tendency is anticipated to place certain restrictions on the development of plasma-derived coagulation factors, which will have an impact on the market's overall growth.
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Global Plasma Fractionation Market Competitive Landscape
To improve their market position, key companies in this market are using a variety of strategies, such as alliances through mergers and acquisitions, geographic expansion, and strategic collaborations. For instance, Terumo Blood and Cell Technologies debuted its most recent production plant in May 2022 in Douglas County, Colorado. The modern production plant, which cost USD $250 million, is in line with the company's goals of improving society via healthcare and serving more people. The 170,000 square foot facility will provide one-time use collection sets for the recently FDA authorized Rika Plasma Donation System, which will give clients (Rika) access to source plasma collections.
Top Player’s Company Profiles in Global Plasma Fractionation Market
- CSL Behring
- Grifols
- Octapharma
- Baxalta/Shire
- Kedrion
- China Biologic Products Holdings
- Sanquin
- Bio Products Laboratory
- Japan Blood Products Organization
- LFB Group
- Shanghai RAAS Blood Products
- Green Cross Corporation
- Baxter International Inc.
- Takeda Pharmaceutical Company Limited
- Beijing Tiantan Biological Products
- Biotest AG
- China National Pharmaceutical Group Co. (Sinopharm)
- GC Pharma
- ADMA Biologics
- Emergent BioSolutions
Global Plasma Fractionation Market Recent Developments
- In October 2022, at its globally manufacturing and distribution hub in Dublin, Ireland, Grifols opened a brand-new facility for the purification and filling of albumin.
- In September 2022, The Ministry of Health, Labor and Welfare of Japan granted manufacturing and marketing approval to CSL Behring K.K. for Berinert S.C. Injection 2000, a lyophilized human C1-esterase the inhibitor concentrate for subcutaneous (SC) injection in plasma derivatives, for the treatment of acute hereditary angioedema (HAE) attacks.
Global Plasma Fractionation Key Market Trends
- Growing Demand for Immunoglobulins: The demand for immunoglobulins is increasing due to their use in the treatment of immune deficiencies and autoimmune diseases. As a result, there has been a significant increase in the production and use of immunoglobulins, which is driving market growth.
- Emergence of New Plasma Fractionation Technologies: There has been a growing trend towards the development of new and advanced plasma fractionation technologies, such as chromatography and filtration techniques. These technologies enable the production of high-quality plasma-derived products with improved safety and efficacy, which is driving market growth.
- Increasing Use of Recombinant Coagulation Factors: The use of recombinant coagulation factors is increasing due to their improved safety and efficacy compared to plasma-derived coagulation factors. This is driving market growth for recombinant coagulation factors, while also limiting the growth of plasma-derived coagulation factors.
- Growing Demand in Emerging Markets: There has been a growing demand for plasma fractionation products in emerging markets, particularly in Asia-Pacific and Latin America. This is due to the increasing prevalence of chronic and rare diseases in these regions, as well as improving healthcare infrastructure and rising healthcare spending.
Global Plasma Fractionation Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates and Analyzes the Data collected by means of Primary Exploratory Research backed by the robust Secondary Desk research.
According to our plasma fractionation market analysis, a major factor in the market's growth is the growing proportion of elderly people in the globe, who are more susceptible to rare conditions that require the use of blood derivatives. The rising use of immunoglobulins and alpha-1-antitrypsin in numerous medical specialties around the world is also projected to fuel market expansion. The increase in blood collection facilities globally is a significant factor promoting the growth of this market.
| Report Metric | Details |
|---|---|
| Market size value in 2021 | USD 28.50 billion |
| Market size value in 2030 | USD 58.24 billion |
| Growth Rate | 8.3% |
| Base year | 2021 |
| Forecast period | 2023-2030 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
|
| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Global Plasma Fractionation Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Global Plasma Fractionation Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Global Plasma Fractionation Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Global Plasma Fractionation Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Global Plasma Fractionation Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Global Plasma Fractionation Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
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