USD 7.8 billion
Oligonucleotide Synthesis Market Size, Share, and Growth Analysis
Oligonucleotide Synthesis Market By Product (Oligonucleotide, Reagents), By Type (Custom Oligos, Predesigned Oligos), By Application (Therapeutic Applications, Diagnostics), By End User (Academic Research Institutes, Pharmaceutical and Biotechnology Companies,), By Region - Industry Forecast 2025-2032
Report ID:
SQMIG35H2107 |
Region:
Global |
Published Date: March, 2025
Pages:
219
|Tables:
67
|Figures:
75
Format -
Oligonucleotide Synthesis Market Insights
Oligonucleotide Synthesis Market size was valued at USD 7.8 billion in 2023 and is poised to grow from USD 9.21 billion in 2024 to USD 34.86 billion by 2032, growing at a CAGR of 18.1% during the forecast period (2025-2032).
Rapidly increasing prevalence of chronic diseases around the world and high investments in medical R&D are projected to primarily propel the demand for oligonucleotide synthesis. The growing popularity of precision and personalized medicine is also expected to generate new business for oligonucleotide synthesis providers in the future. Increasing acceptance of gene therapies for the treatment of various indications and expanding application scope for oligonucleotides in multiple healthcare verticals will also create new opportunities for oligonucleotide synthesis companies. Moreover, advancements in synthesis technologies and the rising use of nucleic acid-based therapeutics are also anticipated to drive oligonucleotide synthesis market growth potential over the coming years. Robust spending on healthcare research in the North American region allows it to become the dominant market for oligonucleotide synthesis companies around the world. On the contrary, high costs of synthesis, complex regulatory framework, ethical concerns regarding gene therapies, and limited manufacturing capacity are some major constraints that slow down oligonucleotide synthesis demand.
Market snapshot - 2025-2032
Global Market Size
Largest Segment
PCR Primers
Fastest Growth
Sequencing Applications
Growth Rate
18.1% CAGR
Global Oligonucleotide Synthesis Market ($ Bn)
Country Share for North America Region (%)
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Oligonucleotide Synthesis Market Segments Analysis
Global Oligonucleotide Synthesis Market is segmented by Product, Type, Application, End User and region. Based on Product, the market is segmented into Oligonucleotide, Reagents and Equipment. Based on Type, the market is segmented into Custom Oligos and Predesigned Oligos. Based on Application, the market is segmented into Therapeutic Applications, Diagnostics, Research and Others. Based on End User, the market is segmented into Academic Research Institutes, Pharmaceutical and Biotechnology Companies,, Diagnostic Laboratories and Others. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.
Oligonucleotide Synthesis Market Analysis by Application
PCR primers are projected to account for a prominent chunk of the global oligonucleotide synthesis market share. Surging investments in genetic research and growing use of PCR primers in the same is also expected to help the dominance of this segment. Advancements in PCR technology is also expected to create new opportunities for oligonucleotide synthesis companies operating in this segment. The crucial role of PCR primers in accurate gene quantification will also contribute to the dominance of this segment.
On the other hand, the demand for oligonucleotide synthesis for sequencing applications is projected to surge at a notable pace over the coming years. Rapidly increasing demand for RNA and DNA sequencing owing to rising popularity of gene therapies and advancements in sequencing technologies are projected to help this segment bolster oligonucleotide synthesis market growth in the future.
Oligonucleotide Synthesis Market Analysis by End Use
Pharmaceutical and biotechnology companies are slated to account for the highest demand for oligonucleotide synthesis around the world. Growing investments in R&D and rising demand for novel drugs and therapeutics are helping pharmaceutical and biotechnology companies spearhead oligonucleotide synthesis demand outlook on a global level. Efficient drug administration through the use of oligonucleotides will also be a factor helping the dominance of this segment.
Meanwhile, the demand for oligonucleotide synthesis in academic research institutes is estimated to rise rapidly across the study period. Growing number of academic research institutes and supportive government initiatives and funding to promote advancements in oligonucleotide synthesis are helping this segment generate new opportunities for oligonucleotide synthesis companies. Increasing the number of collaborations between academic research institutions and pharmaceutical companies will also help this segment bring in major revenue going forward.
Global Oligonucleotide Synthesis Market By Application
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Oligonucleotide Synthesis Market Regional Insights
North America is projected to account for a dominant oligonucleotide synthesis market share. The presence of a strong medical research infrastructure, supportive government funding for research, and rising use of genetic treatments are helping this region maintain its high market share. The United States and Canada are estimated to be the leading markets in this region as incidence of chronic diseases rises in these countries. The presence of leading pharmaceutical and biotechnology companies will also promote the demand for oligonucleotide synthesis in this region.
The surging prevalence demand for precision medicine in the Asia Pacific region makes it the fastest-growing market for oligonucleotide synthesis companies in the world. Increasing investments in genetic research and rising awareness regarding the benefits of gene therapies and therapeutics are expected to bolster oligonucleotide synthesis market growth in this region. Increasing geriatric population and rising healthcare expenditure will also create new opportunities for oligonucleotide synthesis companies in the Asia Pacific region. Japan, China, and India will be the leading markets for oligonucleotide synthesis providers in this region.
Global Oligonucleotide Synthesis Market By Region
- Largest
- Fastest
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Oligonucleotide Synthesis Market Dynamics
Oligonucleotide Synthesis Market Drivers
Rising Application Scope of Oligonucleotides
- Oligonucleotides play a key role in diagnostic tools such as PCR, qPCR, and next-generation sequencing (NGS) and demand for early diagnostics is increasing rapidly. This factor is projected to create new opportunities for oligonucleotide synthesis market growth going forward.
Rising Demand for Gene Therapies
- Oligonucleotides are essential in gene therapies, CRISPR-based gene editing, and personalized medicine. As use and acceptance of gene therapies for the treatment of multiple indications increases, it is also expected to benefit oligonucleotide synthesis demand outlook as well.
Oligonucleotide Synthesis Market Restraints
High Costs of Synthesis
- Oligonucleotide synthesis can be expensive, especially for high-purity or complex oligos required for therapeutic applications. The cost of purification and quality control further adds to the financial burden, limiting accessibility for smaller biotech firms.
Ethical and Safety Concerns of Gene Therapies
- The use of oligonucleotides in gene-editing technologies such as CRISPR has sparked ethical debates and safety concerns, particularly regarding unintended genetic modifications or long-term effects. These concerns may slow the adoption of some oligonucleotide-based applications.
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Oligonucleotide Synthesis Market Competitive Landscape
Investing in the development of oligonucleotide synthesis for different disease indications should remain the prime focus of all companies. Reducing the costs of synthesis will be a major area of interest for all oligonucleotide synthesis providers to improve their profitability. Utilizing supportive government initiatives and funding to maximize R&D scope will also be a popular strategy for oligonucleotide synthesis market players in the future.
Top Players in Oligonucleotide Synthesis Market
- Thermo Fisher Scientific (USA)
- Merck KGaA (Germany)
- Agilent Technologies (USA)
- LGC Biosearch Technologies (UK)
- Integrated DNA Technologies (IDT) (USA)
- Eurofins Genomics (Luxembourg)
- GenScript Biotech Corporation (USA)
- Twist Bioscience (USA)
- Bio-Synthesis Inc. (USA)
- ATUM (USA)
- DNA Script (France)
- SGI-DNA (USA)
- Eurogentec (Kaneka) (Belgium)
- Creative Biogene (USA)
- GeneCust Europe (Luxembourg)
- Synbio Technologies (USA)
- Epoch Life Science, Inc. (USA)
- Bioneer Corporation (South Korea)
- Genewiz (Azenta Life Sciences) (USA)
Oligonucleotide Synthesis Market Recent Developments
- In November 2023, Twist Bioscience Corporation (NASDAQ: TWST), known for its high-quality synthetic DNA produced using its silicon platform, introduced Twist Express Genes, a premier gene synthesis service boasting an order-to-shipping turnaround time of five to seven business days.
- In October 2023, Integrated DNA Technologies (IDT), a leading provider of genomics solutions, announced the completion of its new Therapeutic Oligonucleotide Manufacturing facility in Coralville, Iowa. This marks a significant milestone in IDT's 35-year history, as it marks the company's entry into the therapeutics space. The new facility enables IDT to manufacture products ranging from research-grade to current good manufacturing practice (cGMP) grade cell and gene therapy reagents. This allows researchers to partner with IDT as a single provider to facilitate a seamless transition from laboratory research to therapeutic development.
- In September 2023, Integrated DNA Technologies (IDT) and Aldevron, prominent CRISPR gene editing companies, finalized a new global distribution agreement aimed at broadening essential CRISPR solutions for cell and gene therapy clients. Starting immediately, IDT will carry and offer three additional CRISPR nucleases for research use only (RUO) and current good manufacturing practice (cGMP) applications. These nucleases, manufactured by Aldevron, come with distinct performance attributes, providing researchers with an expedited route to clinical applications.
Oligonucleotide Synthesis Key Market Trends
- Use of AI and Automation: Automation and artificial intelligence are being integrated into oligonucleotide synthesis processes, to enhance the accuracy and scalability of the process. Automated synthesizers and AI-driven design tools are projected to be highly popular as they can assist in cost reduction as well.
- Development of Custom Oligonucleotides: Researchers and diagnostic developers are increasingly requiring custom-designed oligonucleotides for specific applications, such as probe design, sequencing primers, and gene synthesis. This oligonucleotide synthesis market trend is projected to push oligonucleotide synthesis companies to focus on the development of custom oligos to maximize their business in the future.
Oligonucleotide Synthesis Market SkyQuest Analysis
SkyQuest's ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
As per SkyQuest analysis, growing prevalence of chronic diseases and rising demand for personalized medicine are projected to bolster the demand for oligonucleotide synthesis over the coming years. However, high costs of synthesis and ethical concerns of gene therapies are estimated to impede oligonucleotide synthesis market growth potential in the future. North America is projected to lead the demand for oligonucleotide synthesis owing to the presence of robust medical R&D activity. Development of custom oligonucleotides is estimated to be a key trend for oligonucleotide synthesis companies looking to make a mark in the long run.
| Report Metric | Details |
|---|---|
| Market size value in 2023 | USD 7.8 billion |
| Market size value in 2032 | USD 34.86 billion |
| Growth Rate | 18.1% |
| Base year | 2024 |
| Forecast period | 2025-2032 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
|
| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Oligonucleotide Synthesis Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Oligonucleotide Synthesis Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Oligonucleotide Synthesis Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Oligonucleotide Synthesis Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Oligonucleotide Synthesis Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Oligonucleotide Synthesis Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
Oligonucleotide Synthesis Market Report Snapshots
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