USD 4.60 billion
Global Oligonucleotide Synthesis Market Size, Share, Growth Analysis, By End-use(Academic Research Institutes, Diagnostic Laboratories), By Application(PCR Primers, PCR Assays and Panels) - Industry Forecast 2024-2031
Report ID:
SQMIG35H2107 |
Region:
Global |
Published Date: April, 2024
Pages:
219
|
Tables:
67 |
Figures:
75
Global Oligonucleotide Synthesis Market Insights
Global Oligonucleotide Synthesis Market size was valued at USD 4.60 billion in 2022 and is poised to grow from USD 5.16 billion in 2023 to USD 12.86 billion by 2031, at a CAGR of 12.10% during the forecast period (2024-2031).
The purpose of the oligonucleotide synthesis market is to provide researchers, scientists, and manufacturers with custom-made and pre-manufactured oligonucleotides for various applications, including gene synthesis, PCR, DNA sequencing, diagnostics, and therapeutics. The increasing demand for synthetic biology and personalized medicine is the primary driving factor for the oligonucleotide synthesis market. The increasing prevalence of cancer and genetic disorders is also boosting the demand for oligonucleotides in the market. The oligonucleotide synthesis market faces several challenges, including quality control, regulatory compliance, and ethical concerns related to gene synthesis. The increasing complexity of oligonucleotide synthesis and the need for specialized equipment and expertise pose significant challenges to market players. The oligonucleotide synthesis market presents several opportunities for market players, including the development of new and innovative oligonucleotide synthesis technologies, the expansion of the application areas for oligonucleotides, and the increasing demand for personalized medicine and gene therapy. The oligonucleotide synthesis market is expected to continue its growth trajectory in the coming years, driven by the increasing demand for synthetic biology and personalized medicine. However, the market may face challenges related to cost, technical expertise, quality control, and regulatory compliance.
Market snapshot - 2024-2031
Global Market Size
Largest Segment
Academic Research Institutes
Fastest Growth
Diagnostic Laboratories
Growth Rate
12.10% CAGR
Global Oligonucleotide synthesis Market ($ Bn)
Country Share for North America Region (%)
Global Comparators Market Size By End-use ($ Bn)
Global Oligonucleotide synthesis Market By End-use (%)
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Global Oligonucleotide Synthesis Market Segmental Analysis
The global oligonucleotide synthesis market is segmented on the basis of end-use, application, and region. Based on categorization by end-use, the market is segmented into Academic Research Institutes, Diagnostic Laboratories, and Pharmaceutical - Biotechnology Companies. In terms of categorization by application, the market is segmented into PCR Primers, PCR Assays and Panels, Sequencing, DNA Microarrays, Fluorescence in Situ Hybridization (FISH), Antisense Oligonucleotides, and Other Applications. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Oligonucleotide Synthesis Market Analysis by End-use
Pharmaceutical and biotechnology companies are actively searching for alternative approaches to treat diseases, which has led to the increasing usage of oligonucleotides due to their effective mode of action and lower development costs. Oligonucleotides also offer a solution to the challenge of administering drugs efficiently. Consequently, there is a rise in the manufacturing of oligonucleotide therapeutics, resulting in increased market share of pharmaceutical and biotechnology companies.
Governments and private organizations are investing in academic and research infrastructure in emerging economies, which is anticipated to boost the adoption of oligonucleotides in academic research institutes. The dominant market share of the academic research segment is driven by the surge in genomic research projects. Additionally, collaboration between major industry players and universities to develop novel genetic medicine approaches for curing chronic conditions is expected to contribute to the growth of this segment.
Oligonucleotide Synthesis Market Analysis by Application
PCR primers play a significant role in drug development by facilitating target screening and identification. Currently, there is a strong pipeline of oligonucleotide-based therapeutics, such as antisense therapeutics, DNA vaccines, and antiviral agents, in various phases of clinical development, which has led to PCR primers holding the largest revenue share in the oligonucleotide synthesis market.
The growing emphasis on targeted gene therapies has transformed the treatment of previously incurable conditions caused by genetic mutations. As a result, manufacturers are experiencing an increase in demand for sequencing applications from clinical, diagnostic, academic, and drug development sectors.
Global Oligonucleotide synthesis Market By End-use, 2023 (%)
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Global Oligonucleotide Synthesis Market Regional Insights
North America dominated the global oligonucleotide synthesis market owing to the presence of major pharmaceutical and biotech companies in the region. The high adoption of advanced genomic technologies and the availability of a skilled workforce for the development of novel therapeutics is further projected to help this region continue dominance during the forecast period.
Asia-Pacific region is the fastest growing region in the oligonucleotide synthesis market due to the increasing focus on precision medicine and the rising number of research collaborations between academic institutions and biotech companies. The increasing demand for custom oligonucleotide synthesis services and the growing investments in genomics research also contribute to the growth of the market in the region.
Global Oligonucleotide synthesis Market By Region, 2024-2031
- Largest
- Fastest
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Global Oligonucleotide Synthesis Market Dynamics
Oligonucleotide Synthesis Market Drivers
Increasing Demand for Synthetic Oligonucleotides in Drug Development and Diagnostics
- The growing demand for oligonucleotides in drug development and diagnostics is a key driver of the global oligonucleotide synthesis market. PCR primers, antisense oligonucleotides, and siRNA are just a few examples of oligonucleotides that are widely used in drug development and diagnostics.
Growing Focus on Targeted Gene Therapies
- The increasing focus on targeted gene therapies is another major driver of the global oligonucleotide synthesis market. Targeted gene therapies are designed to treat genetic mutations that cause incurable diseases, and synthetic oligonucleotides play a crucial role in this process.
Oligonucleotide Synthesis Market Restraints
High Cost of Oligonucleotide Synthesis
- The high cost of oligonucleotide synthesis is a significant restraint for the market. Oligonucleotide synthesis is a complex process that requires specialized equipment and expertise, and this drives up the cost of manufacturing oligonucleotides.
Stringent Regulations
- The stringent regulatory environment in the pharmaceutical industry is another significant restraint for the oligonucleotide synthesis market. Regulatory agencies such as the FDA closely monitor the development and production of oligonucleotide-based therapies, and this can lead to delays and increased costs for manufacturers.
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Global Oligonucleotide Synthesis Market Competitive Landscape
The global oligonucleotide synthesis market is highly competitive and fragmented, with a large number of players operating in the market. The oligonucleotide synthesis market is driven by strategic initiatives such as collaborations, partnerships, and mergers and acquisitions. The oligonucleotide synthesis market is expected to witness intense competition among players, with a focus on innovation, product differentiation, and expansion of geographical presence.
Oligonucleotide Synthesis Market Top Player’s Company Profiles
- Biolytic Lab Performance Inc. (Canada)
- Eurofins Genomics LLC (US)
- General Electric Company (US)
- GenScript Biotech Corporation (China)
- Integrated DNA Technologies, Inc. (US)
- Kaneka Eurogentec S.A. (Belgium)
- LGC Limited (UK)
- Merck KGaA (Germany)
- Nitto Denko Avecia Inc. (US)
- Thermo Fisher Scientific Inc. (US)
- TriLink BioTechnologies, LLC (US)
- Twist Bioscience Corporation (US)
- ATDBio Ltd. (UK)
- Axil Scientific Pte Ltd. (Singapore)
- Biogen International GmbH (Switzerland)
- Biomer Technology LLC (US)
- Bio-Synthesis, Inc. (US)
Oligonucleotide Synthesis Market Recent Developments
- In November 2023, Twist Bioscience Corporation (NASDAQ: TWST), known for its high-quality synthetic DNA produced using its silicon platform, introduced Twist Express Genes, a premier gene synthesis service boasting an order-to-shipping turnaround time of five to seven business days.
- In October 2023, Integrated DNA Technologies (IDT), a leading provider of genomics solutions, announced the completion of its new Therapeutic Oligonucleotide Manufacturing facility in Coralville, Iowa. This marks a significant milestone in IDT's 35-year history, as it marks the company's entry into the therapeutics space. The new facility enables IDT to manufacture products ranging from research-grade to current good manufacturing practice (cGMP) grade cell and gene therapy reagents. This allows researchers to partner with IDT as a single provider to facilitate a seamless transition from laboratory research to therapeutic development.
- In September 2023, Integrated DNA Technologies (IDT) and Aldevron, prominent CRISPR gene editing companies, finalized a new global distribution agreement aimed at broadening essential CRISPR solutions for cell and gene therapy clients. Starting immediately, IDT will carry and offer three additional CRISPR nucleases for research use only (RUO) and current good manufacturing practice (cGMP) applications. These nucleases, manufactured by Aldevron, come with distinct performance attributes, providing researchers with an expedited route to clinical applications.
Global Oligonucleotide Synthesis Key Market Trends
- Increasing Demand for Customized Oligonucleotides: There has been a growing demand for customized oligonucleotides, which are tailored to specific applications. Customized oligonucleotides are used in various applications, including research, diagnostics, and therapeutics. The growing demand for customized oligonucleotides is attributed to the increasing use of oligonucleotides in drug discovery and development, genetic testing, and personalized medicine. For instance, Integrated DNA Technologies, a leading provider of customized oligonucleotides, offers a wide range of oligonucleotides for research, diagnostics, and therapeutic applications.
- Rising Applications in Drug Discovery and Development: Oligonucleotides have emerged as a promising class of therapeutics in drug discovery and development. Oligonucleotide therapeutics have the potential to target various diseases, including genetic disorders, infectious diseases, and cancer. The development of antisense oligonucleotides and RNA interference (RNAi) technology has revolutionized the field of drug discovery and development. For instance, Ionis Pharmaceuticals, a leading biopharmaceutical company, has developed several oligonucleotide-based therapeutics for the treatment of rare diseases, including spinal muscular atrophy and Huntington's disease.
Global Oligonucleotide Synthesis Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyzes the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
According to our global oligonucleotide synthesis market analysis, the market is anticipated to witness substantial growth during the forecast period. The growth is attributed to the increasing prevalence of genetic disorders, the rising demand for personalized medicines, and the growing number of research activities in genomics and proteomics. Moreover, technological advancements in the field of oligonucleotide synthesis are expected to drive the growth of the market. The DNA oligonucleotides segment dominated the market in 2021 and is anticipated to maintain its dominance during the forecast period. The research segment dominated the market in 2021 and is expected to maintain its dominance during the forecast period. This can be attributed to the increasing focus of researchers on genomic research and drug discovery. The global oligonucleotide synthesis market is expected to witness significant growth during the forecast period, driven by factors such as the increasing prevalence of genetic disorders, growing demand for personalized medicines, and technological advancements in the field of oligonucleotide synthesis.
| Report Metric | Details |
|---|---|
| Market size value in 2023 | USD 4.60 billion |
| Market size value in 2031 | USD 12.86 billion |
| Growth Rate | 12.10% |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
|
| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Global Oligonucleotide Synthesis Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Global Oligonucleotide Synthesis Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Global Oligonucleotide Synthesis Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Global Oligonucleotide Synthesis Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Global Oligonucleotide Synthesis Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Global Oligonucleotide Synthesis Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
Global Oligonucleotide Synthesis Market Report Snapshots
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