Immune Checkpoint Inhibitors Market Size, Share, and Growth Analysis

Immune Checkpoint Inhibitors Market By Type (PD-1 Inhibitor, PD-L1 Inhibitor), By Application (Lung Cancer, Colorectal Cancer), By Distribution Channel (Hospitals Pharmacies, Online Pharmacies), By Region -Industry Forecast 2025-2032


Report ID: SQMIG35G2308 | Region: Global | Published Date: January, 2025
Pages: 189 |Tables: 89 |Figures: 68

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Immune Checkpoint Inhibitors Market Insights

Global Immune Checkpoint Inhibitors Market size was valued at USD 48.42 Billion in 2023 and is poised to grow from USD 57.09 Billion in 2024 to USD 213.13 Billion by 2032, growing at a CAGR of 17.9% in the forecast period (2025-2032).

The growing prevalence of cancer such as lung, breast, bladder, and cervical cancer along with melanomas, and Hodgkin lymphoma has led to a wider use of immune checkpoint inhibitor treatment. According to the Canadian Cancer Society, two in five Canadians are estimated to be diagnosed with cancer in their lifetime and one in four is likely to die due to the disease in the country. The incidence of the disease is rising steadily, which is expected to boost demand for effective diagnostic methods, including immune checkpoint inhibitors. Increasing focus on development of novel immune checkpoint inhibitors by numerous research organizations is projected to positively impact the market growth during the forecast period. Despite these barriers, the immune checkpoint inhibitors market shows strong growth potential, particularly in emerging economies.

The checkpoint inhibitor pembrolizumab for the treatment of MSI-H and dMMR tumors was the first FDA approval based exclusively on the presence of a genetic feature in a tumor. There is continuing competition in the immune checkpoint inhibitors market that has resulted in the growth of the market. Additionally, rising technological advancements in the treatment of cancer and increasing awareness among the population regarding immune system disease are restraining the growth of the immune checkpoint inhibitors market.

Market snapshot - (2025-2032)

Global Market Size

USD 48.42 Billion

Largest Segment

Hospitals Pharmacies

Fastest Growth

Online Pharmacies

Growth Rate

17.9% CAGR

Global Immune Checkpoint Inhibitors Market ($ Bn)
Country Share for North America Region (%)

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Immune Checkpoint Inhibitors Market Segments Analysis

The global immune checkpoint inhibitors market is segmented into type, application, distribution channel and region. Based on type, the market is segmented into CTLA-4 inhibitor, PD-1 inhibitor and PD-L1 inhibitor. Based on application, the market is segmented into lung cancer, bladder cancer, melanoma, hodgkin lymphoma, colorectal cancer and others. Based on distribution channel, the market is segmented into hospitals pharmacies and online pharmacies. Based on region, the market is segmented into North America, Europe, Asia-Pacific, Middle East and Africa, and Latin America.

Analysis by Distribution Channel

As per global immune checkpoint inhibitors market analysis, the hospitals pharmacies segment dominated the market with the largest revenue share of 57.06% in 2024. Immunotherapy treatments including immune checkpoint inhibitor drugs are more frequently conducted in hospital settings compared to other healthcare environments. This is attributed to the widespread availability of hospitals for primary care in numerous developing economies and a favourable reimbursement structure. Furthermore, increasing collaborations between pharmaceutical companies, academic institutions, and hospitals can facilitate access to clinical trials and early drug adoption. According to a 2023 study, supported by AstraZeneca and the National Institute of Cancer, durvalumab, offers a promising therapeutic option in patients suffering from non-small cell lung cancer. Such partnerships can drive the integration of immune checkpoint inhibitors into hospital pharmacies for cancer care, thereby propelling the segment growth.

As per global immune checkpoint inhibitors market outlook, the online pharmacies segment is projected to witness at the fastest CAGR during the forecast period. Online pharmacies offer a convenient and accessible platform for patients to order and receive immune checkpoint inhibitor-based drugs. The increasing adoption of digital health solutions and telemedicine has facilitated the growth of online pharmacies. Patients receive prescriptions digitally and choose online platforms for the procurement of immune checkpoint inhibitors, aligning with broader trends in virtual healthcare. Growing internet accessibility globally contributes to the expansion of online pharmacies. Patients can easily access information about immune checkpoint inhibitors, compare products, and make informed decisions from the comfort of their homes.

Analysis by Application

The lung cancer segment dominated the market with the largest revenue share of 26.41% in 2023. Rising prevalence and mortality due to lung cancer is a key factor contributing to the segment growth. In addition, companies operating in the market are continuously involved in the development and launch of novel immune checkpoint inhibitors for treatment of patients with lung cancer. For instance, in January 2023, Merck & Co., Inc. received approval for KEYTRUDA (pembrolizumab) as an alternative treatment option for patients following platinum-based chemotherapy and surgical resection. The drug is indicated for patients with stage IB, II, IIIA non-small cell lung cancer. Thus, prominent applications of immune checkpoint inhibitors in treatment are driving segment growth.

The colorectal cancer segment is expected to register at a significant CAGR during the forecast period. The growing prevalence of CRC is one of the primary factors boosting the demand for therapeutics during the forecast period. According to the statistics published by WHO in July 2023, colorectal cancer (CRC) is the third-most common type across the globe. Approximately 1 in 10 cancer patients have CRC. It is the second-leading cause of cancer-related deaths across the world. Moreover, key players in the market are focusing on R&D activities and receiving U.S. FDA approval for treatment of colorectal cancer.

Global Immune Checkpoint Inhibitors Market By Distribution Channel (%)

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Immune Checkpoint Inhibitors Market Regional Insights

North America dominated the immune checkpoint inhibitors market for the largest revenue share of 63.81% in 2024, owing to high prevalence of neoplasms in the region. The increasing government funding and support for the expansion of new drug development for cancer treatment. Moreover, boost in research and development for new and novel drugs in the market is also supporting the regional growth. The government's help through funding for new drug development for the treatment of cancer is driving the growth of the immune checkpoint inhibitors market. Moreover, the escalating prevalence of cancer in the region amplifies the demand for these treatments.

The immune checkpoint inhibitors market in Asia Pacific is anticipated to witness a significant CAGR during the forecast period, owing to several factors, such as increasing healthcare reforms. Other factors contributing to market growth are improving healthcare infrastructure, a growing population, and rising number of local companies entering the market. Moreover, Asia Pacific has a large population and a high prevalence of cancer. According to Global Cancer Statistics, the estimated number of new cases of cancer in Asia in 2022 was 10.5 million. In addition, increasing focus on the development and approval of immune checkpoint inhibitors by key operating players in the market is projected to fuel the market during the forecast period.

Global Immune Checkpoint Inhibitors Market By Geography
  • Largest
  • Fastest

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Immune Checkpoint Inhibitors Market Dynamics

Drivers

Advancements in Immunotherapy

  • Technological advancements and scientific breakthroughs in immunotherapy have significantly propelled the immune checkpoint inhibitors market. Over the past decade, research has unveiled the critical role of the immune system in combating cancer, leading to the development of therapies that enhance the body's immune response to tumor cells. Immune checkpoint inhibitors, which target specific proteins that regulate immune checkpoints, have emerged as a keystone of modern oncology.

Increasing Approvals and Indications

  • Regulatory approvals of new immune checkpoint inhibitors and the expansion of indications for existing ones have been pivotal in driving market growth. Agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved several immune checkpoint inhibitors for various cancer types, including melanoma, non-small cell lung cancer, renal cell carcinoma, and more. These approvals not only enhance the therapeutic arsenal available to oncologists but also encourage pharmaceutical companies to invest in the development of new inhibitors.

Restraints

High Cost of Treatment

  • One of the most significant restraints affecting the growth of the global immune checkpoint inhibitors industry is the high cost associated with these treatments. Immune checkpoint inhibitors, such as pembrolizumab (Keytruda) and nivolumab (Opdivo), are often priced at a premium due to the substantial investment in research and development, complex manufacturing processes, and the high cost of clinical trials. The cost of a single course of treatment can reach tens of thousands of dollars, making it prohibitively expensive for many patients and healthcare systems, especially in low and middle-income countries.

Impact on Patients and Healthcare Systems

  • The high cost of immune checkpoint inhibitors limits patient access, particularly for those without comprehensive health insurance or in countries where healthcare coverage is inadequate. Patients may face significant out-of-pocket expenses, leading to financial hardship or inability to afford treatment. This financial barrier not only affects individual patients but also places a heavy burden on healthcare systems and insurance providers. As a result, the adoption and utilization of these therapies can be restricted, impacting the overall growth of the market.

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Immune Checkpoint Inhibitors Market Competitive Landscape

The global immune checkpoint inhibitors market is characterized by intense competition among a mix of established pharmaceutical giants and emerging biotechnology companies. Key players in the market include Merck & Co., Bristol-Myers Squibb, Roche, AstraZeneca, and Pfizer, which dominate due to their extensive product portfolios, robust R&D capabilities, and strong global presence. The competitive landscape of the global immune checkpoint inhibitors market is dynamic and multifaceted, driven by innovation, strategic partnerships, and a relentless pursuit of market leadership.

Top Players in Immune Checkpoint Inhibitors Market

  • Sanofi
  • F. Hoffmann-La Roche Ltd.
  • Merck & Co.
  • Bristol-Myers Squibb Company
  • Eli Lilly and Company
  • Regeneron Pharmaceuticals Inc.
  • AstraZeneca PLC
  • Shanghai Jhunsi Biosciences Ltd
  • Immutep Ltd
  • BeiGene Ltd
  • GlaxoSmithKline PLC
  • Novartis AG

Recent Developments

  • In October 2023, Bristol Myers Squibb, received U.S. FDA approval of Opdivo (nivolumab) for treatment of completely resected stage IIB or Stage IIC melanoma in adult and pediatric patients aged 12 years and older.
  • in August 2023, the Department of Urologic Surgery in the UC Davis Comprehensive Cancer Center received a USD 1.4 million grant from the Department of Defense Congressionally Directed Medical Research Program.
  • In January 2023, Merck & Co, entered a clinical trial collaboration with Teon Therapeutics, to evaluate the efficiency of TT-816 in combination with KEYTRUDA (pembrolizumab). This drug is indicated for patients with advanced solid tumors.

Immune Checkpoint Inhibitors Key Market Trends

Immune Checkpoint Inhibitors Market SkyQuest Analysis

SkyQuest's ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by the robust Secondary Desk research.

According to SkyQuest analysis, immune checkpoint inhibitors enhance the immune system's ability to identify and attack cancer cells. They have shown significant effectiveness against various cancers, such as melanoma, lung cancer, and renal cell carcinoma. The growing adoption of these therapies is supported by extensive clinical trials, favourable regulatory approvals, and their integration into established treatment protocols, all of which drive global immune checkpoint inhibitors market growth. Moreover, the technological advancement in the screening or broadcast method for cancer and increasing healthcare expenditures in this market. The increase in the adoption of immune checkpoint inhibitor drugs in emerging markets, are factors propelling the growth of the immune checkpoint inhibitors market. Furthermore, severe FDA guidelines for the drug approval of new drugs & adverse effects, challenge the growth of the global immune checkpoint inhibitors industry.

Report Metric Details
Market size value in 2023 USD 48.42 Billion
Market size value in 2032 USD 213.13 Billion
Growth Rate 17.9%
Base year 2024
Forecast period (2025-2032)
Forecast Unit (Value) USD Billion
Segments covered
  • Type
    • CTLA-4 Inhibitor, PD-1 Inhibitor and PD-L1 Inhibitor
  • Application
    • Lung Cancer, Bladder Cancer, Melanoma, Hodgkin Lymphoma, Colorectal Cancer and Others
  • Distribution Channel
    • Hospitals Pharmacies and Online Pharmacies
Regions covered North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA)
Companies covered
  • Sanofi
  • F. Hoffmann-La Roche Ltd.
  • Merck & Co.
  • Bristol-Myers Squibb Company
  • Eli Lilly and Company
  • Regeneron Pharmaceuticals Inc.
  • AstraZeneca PLC
  • Shanghai Jhunsi Biosciences Ltd
  • Immutep Ltd
  • BeiGene Ltd
  • GlaxoSmithKline PLC
  • Novartis AG
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Table Of Content

Executive Summary

Market overview

  • Exhibit: Executive Summary – Chart on Market Overview
  • Exhibit: Executive Summary – Data Table on Market Overview
  • Exhibit: Executive Summary – Chart on Immune Checkpoint Inhibitors Market Characteristics
  • Exhibit: Executive Summary – Chart on Market by Geography
  • Exhibit: Executive Summary – Chart on Market Segmentation
  • Exhibit: Executive Summary – Chart on Incremental Growth
  • Exhibit: Executive Summary – Data Table on Incremental Growth
  • Exhibit: Executive Summary – Chart on Vendor Market Positioning

Parent Market Analysis

Market overview

Market size

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • SWOT Analysis

KEY MARKET INSIGHTS

  • Technology Analysis
    • (Exhibit: Data Table: Name of technology and details)
  • Pricing Analysis
    • (Exhibit: Data Table: Name of technology and pricing details)
  • Supply Chain Analysis
    • (Exhibit: Detailed Supply Chain Presentation)
  • Value Chain Analysis
    • (Exhibit: Detailed Value Chain Presentation)
  • Ecosystem Of the Market
    • Exhibit: Parent Market Ecosystem Market Analysis
    • Exhibit: Market Characteristics of Parent Market
  • IP Analysis
    • (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
  • Trade Analysis
    • (Exhibit: Data Table: Import and Export data details)
  • Startup Analysis
    • (Exhibit: Data Table: Emerging startups details)
  • Raw Material Analysis
    • (Exhibit: Data Table: Mapping of key raw materials)
  • Innovation Matrix
    • (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
  • Pipeline product Analysis
    • (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
  • Macroeconomic Indicators

COVID IMPACT

  • Introduction
  • Impact On Economy—scenario Assessment
    • Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
  • Revised Market Size
    • Exhibit: Data Table on Immune Checkpoint Inhibitors Market size and forecast 2021-2027 ($ million)
  • Impact Of COVID On Key Segments
    • Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
  • COVID Strategies By Company
    • Exhibit: Analysis on key strategies adopted by companies

MARKET DYNAMICS & OUTLOOK

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • Regulatory Landscape
    • Exhibit: Data Table on regulation from different region
  • SWOT Analysis
  • Porters Analysis
    • Competitive rivalry
      • Exhibit: Competitive rivalry Impact of key factors, 2021
    • Threat of substitute products
      • Exhibit: Threat of Substitute Products Impact of key factors, 2021
    • Bargaining power of buyers
      • Exhibit: buyers bargaining power Impact of key factors, 2021
    • Threat of new entrants
      • Exhibit: Threat of new entrants Impact of key factors, 2021
    • Bargaining power of suppliers
      • Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
  • Skyquest special insights on future disruptions
    • Political Impact
    • Economic impact
    • Social Impact
    • Technical Impact
    • Environmental Impact
    • Legal Impact

Market Size by Region

  • Chart on Market share by geography 2021-2027 (%)
  • Data Table on Market share by geography 2021-2027(%)
  • North America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • USA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Canada
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Europe
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Germany
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Spain
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • France
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • UK
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Europe
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Asia Pacific
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • China
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • India
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Japan
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Korea
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Asia Pacific
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Latin America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Brazil
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of South America
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Middle East & Africa (MEA)
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • GCC Countries
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Africa
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of MEA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)

KEY COMPANY PROFILES

  • Competitive Landscape
    • Total number of companies covered
      • Exhibit: companies covered in the report, 2021
    • Top companies market positioning
      • Exhibit: company positioning matrix, 2021
    • Top companies market Share
      • Exhibit: Pie chart analysis on company market share, 2021(%)

Methodology

For the Immune Checkpoint Inhibitors Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:

1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.

2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Immune Checkpoint Inhibitors Market.

3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.

4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.

Analyst Support

Customization Options

With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Immune Checkpoint Inhibitors Market:

Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.

Regional Analysis: Further analysis of the Immune Checkpoint Inhibitors Market for additional countries.

Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.

Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.

Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.

Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.

Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.

Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.

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FAQs

Global Immune Checkpoint Inhibitors Market size was valued at USD 48.42 Billion in 2023 and is poised to grow from USD 57.09 Billion in 2024 to USD 213.13 Billion by 2032, growing at a CAGR of 17.9% in the forecast period (2025-2032).

The global immune checkpoint inhibitors market is characterized by intense competition among a mix of established pharmaceutical giants and emerging biotechnology companies. Key players in the market include Merck & Co., Bristol-Myers Squibb, Roche, AstraZeneca, and Pfizer, which dominate due to their extensive product portfolios, robust R&D capabilities, and strong global presence. The competitive landscape of the global immune checkpoint inhibitors market is dynamic and multifaceted, driven by innovation, strategic partnerships, and a relentless pursuit of market leadership. 'Sanofi', 'F. Hoffmann-La Roche Ltd.', 'Merck & Co.', 'Bristol-Myers Squibb Company', 'Eli Lilly and Company', 'Regeneron Pharmaceuticals Inc.', 'AstraZeneca PLC', 'Shanghai Jhunsi Biosciences Ltd', 'Immutep Ltd', 'BeiGene Ltd', 'GlaxoSmithKline PLC', 'Novartis AG '

Technological advancements and scientific breakthroughs in immunotherapy have significantly propelled the immune checkpoint inhibitors market. Over the past decade, research has unveiled the critical role of the immune system in combating cancer, leading to the development of therapies that enhance the body's immune response to tumor cells. Immune checkpoint inhibitors, which target specific proteins that regulate immune checkpoints, have emerged as a keystone of modern oncology.

Rising Incidence of Cancer: One of the primary drivers of the global immune checkpoint inhibitors market is the increasing incidence of cancer worldwide. Cancer remains one of the leading causes of morbidity and mortality globally, with millions of new cases diagnosed each year. As the global population ages and lifestyles change, the prevalence of cancer is expected to rise, creating a larger patient pool requiring innovative and effective treatment options.

North America dominated the immune checkpoint inhibitors market for the largest revenue share of 63.81% in 2024, owing to high prevalence of neoplasms in the region. The increasing government funding and support for the expansion of new drug development for cancer treatment. Moreover, boost in research and development for new and novel drugs in the market is also supporting the regional growth. The government’s help through funding for new drug development for the treatment of cancer is driving the growth of the immune checkpoint inhibitors market. Moreover, the escalating prevalence of cancer in the region amplifies the demand for these treatments.

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Immune Checkpoint Inhibitors Market

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