USD 30.98 billion
Global Downstream Processing Market Size, Share, Growth Analysis, By Product(Chromatography Systems, Filters), By Technique(Cell Disruption, Solid-Liquid Separation) - Industry Forecast 2024-2031
Report ID:
SQMIG35H2109 |
Region:
Global |
Published Date: March, 2024
Pages:
219
|
Tables:
67 |
Figures:
77
Global Downstream Processing Market Insights
Global Downstream Processing Market size was valued at USD 30.98 billion in 2022 and is poised to grow from USD 35.69 billion in 2023 to USD 110.79 billion by 2031, at a CAGR of 15.21% during the forecast period (2024-2031).
Expanding bioprocessing capacity, greater single-use technology acceptance in bioprocessing, rising R&D spending in pharmaceutical companies, and rising biopharmaceutical market demand are the primary factors driving the global market demand for biopharmaceuticals. For instance, the biopharmaceuticals sector of the global market is consistently growing.
Merck and Wuxi National High-tech Industrial Development Zone reached a collaboration agreement in April 2022. The scale of Merck's manufacturing plant in Wuxi, Jiangsu Province, China, will be increased in compliance with the terms of the agreement. The production of commercial enzymes, flavourings, and natural perfumes also depends on it.
US Downstream Processing Market is poised to grow at a sustainable CAGR for the next forecast year.
Market snapshot - 2024-2031
Global Market Size
Largest Segment
Antibiotic Production
Fastest Growth
Antibiotic Production
Growth Rate
15.21% CAGR
Global Downstream Processing Market 2022-2030 ($ Bn)
Country Share for North America Region- 2022 (%)
Global Downstream Processing Market Size By Application 2022-2030 ($ Bn)
Global Downstream Processing Market Size By Application 2022-2030 (%)
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Global Downstream Processing Market Segmental Analysis
Global Downstream Processing Market is segmented on the basis of product, technique, application and region. By product, the market is segmented into chromatography systems, filters, evaporators, centrifuges, dryers. By technique, market is segmented into cell disruption, solid-liquid separation, concentration, purification by chromatography, formulation. By application, the market is segmented into antibiotic production, hormone production, antibodies production, enzyme production, vaccine production. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Downstream Processing Market Analysis by Technique
In 2022, the downstream processing market was dominated by the purification by chromatography segment, which contributed 40.98% of total revenue. Because single-use chromatography and filtration systems are the industry benchmarks for downstream bioprocessing, businesses are pursuing business development techniques including acquisition, merger, and agreement to diversify their chromatography offerings. Repligen, for instance, purchased BioFlex Solutions, a company situated in Newton, New Jersey. Aside from streamlining its supply chain, the acquisition expands and improves Repligen's line of single-use fluid management products. By adding more integrated components and assemblies, the incorporation of BioFlex Solutions increases its system offering.
The sector with the highest CAGR from 2023 to 2030 is solid-liquid separation, at 16.03%. Solid-liquid separation has various benefits, including the fact that it is easy to use, economical, and suitable for continuous manufacturing. The common challenge with this approach is strong shear forces created. In order to address these issues, recent innovations including depth filters, multistage depth filtration, alternating tangential flow microfiltration, and tangential flow filtration technologies are being used more frequently in high cell density processes.
Downstream Processing Market Analysis by Product
The downstream processing market was headed by the chromatography systems category in 2022, which also had the biggest revenue share (41.29%). Ongoing R&D to improve the efficiency and speed of chromatography systems is anticipated to boost the segment's expansion. Thermo Fisher Scientific introduced the HyPeak chromatography system, their sole single-use chromatography system for bioprocessing, which plays a vital role in the production of therapeutic proteins and vaccines. Growth of the industry is also aided by an increase in deals and innovations involving chromatography systems.
The fastest CAGR, 16.10%, is anticipated for the filters segment between 2023 and 2030. The key factor propelling this market for downstream processing is the expansion of filters' viral inactivation utility. The effectiveness of BioEX hollow fiber and Planova 20N virus filters for the elimination of viral-size particles was examined by a team of researchers from Pennsylvania State University. It is hoped that such studies will accelerate the use of filters for biologics' downstream processing.
Global Downstream Processing Market Size By Application 2022(%), 2023 (%)
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Global Downstream Processing Market Regional Insights
Due to government assistance for developing bioprocess technologies, rising medical costs, and an established healthcare infrastructure, North America held a lion's share of the downstream processing market in 2022 with a revenue share of 34.57%. Furthermore, the region has experienced substantial joint ventures with pharmaceutical industry giants that are heavily sponsoring the production of vaccines and biopharmaceuticals. Additionally, major firms in the downstream processing market are growing their presence in this area.
Due to increasing investments in biotechnology by consumers and developers, the downstream processing market in the Asia Pacific is anticipated to increase at the fastest pace among all markets, 15.67%, between 2023 and 2030. Players are eager to deploy rapid analytical approaches to enable in-process planning and bioprocessing for improved medical facilities that are required by a big population base. Due to the expanding biopharmaceutical industry and rising demand for drugs and vaccines, China had the lion's share of the market share in the Asia Pacific region. Among China's most dynamic economic sectors, the biopharmaceutical sector is characterized by a constant revolution driven by cutting-edge biopharmaceutical technology and procedures.
Global Downstream Processing Market Size By Geography, 2022-2030, 2024-2031
- Largest
- Fastest
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Global Downstream Processing Market Dynamics
Downstream Processing Market Drivers
Increasing Demand for Biopharmaceuticals to Bring Lucrative Opportunities
- The demand for biopharmaceuticals, such as monoclonal antibodies, vaccines, and recombinant proteins, has been steadily rising. Downstream processing plays a crucial role in purifying and isolating these complex biological products, ensuring their safety and efficacy. As the biopharmaceutical industry expands, the demand for downstream processing technologies and equipment grows.
- The continuous advancements in biotechnology have led to the development of new and complex biopharmaceutical products. Downstream processing techniques and equipment have evolved to meet the challenges associated with processing these advanced therapies. The ability to efficiently purify and separate complex biomolecules has become essential in the biotechnology industry, driving the adoption of downstream processing solutions.
Downstream Processing Market Restraints
Product-Specific Challenges Pose as a Threat
- Each biopharmaceutical product has its unique characteristics, such as size, charge, solubility, and stability, which can present challenges in downstream processing. Some products may exhibit low yields, difficult purification, or susceptibility to degradation during the purification steps. Developing tailored downstream processes for different products and addressing product-specific challenges can be complex and require significant expertise and optimization efforts.
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Global Downstream Processing Market Competitive Landscape
These companies compete based on factors such as product portfolio, technological advancements, pricing strategies, customer relationships, and global presence. They strive to differentiate themselves by offering innovative solutions, providing excellent customer support, and continuously improving their offerings to meet the evolving demands of the biopharmaceutical industry.
Downstream Processing Market Top Player’s Company Profiles
- Sartorius AG (Germany)
- Danaher Corporation (United States)
- 3M Company (United States)
- MilliporeSigma (United States)
- Novasep Holding S.A.S. (France)
- Lonza Group Ltd. (Switzerland)
- Eppendorf AG (Germany)
- Repligen Corporation (United States)
- Charles River Laboratories International, Inc. (United States)
- Boehringer Ingelheim International GmbH (Germany)
- Avantor, Inc. (United States)
- Corning Incorporated (United States)
- Pall Corporation (United States)
- Shimadzu Corporation (Japan)
- Agilent Technologies, Inc. (United States)
- ABEC, Inc. (United States)
- Nova Biomedical (United States)
- JSR Corporation (Japan)
- NIZO (Netherlands)
Downstream Processing Market Recent Developments
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In March 2024, MilliporeSigma announced a strategic partnership with Lotte to equip a former Bristol Myers Squibb (BMS) plant.
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In March 2024, MilliporeSigma made a substantial advancement in enhancing manufacturing flexibility and productivity by introducing the EX-CELL® Advanced™ HD Perfusion Medium. This creative off-the-shelf cell culture media is designed to support perfusion processes, enabling high productivity even at low perfusion rates. This enhancement aims to boost production yield and accelerate the speed of clinical development.
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In February 2024, BASF SE, based in Ludwigshafen, Germany, officially commenced the divestment process for its shares in two joint venture companies: BASF Markor Chemical Manufacturing (Xinjiang) Co, Ltd and Markor Meiou Chemical (Xinjiang) Co, Ltd, located in Korla, China. This decision formulated in late 2023 is by BASF's worldwide methodology regarding 1,4-butanediol (BDO), a key chemical in its portfolio.
Global Downstream Processing Key Market Trends
- Process intensification involves optimizing downstream processing operations to achieve higher productivity, improved yield, and reduced processing times. Continuous manufacturing approaches, such as continuous chromatography and continuous centrifugation, are gaining prominence as they enable real-time monitoring, process control, and enhanced process efficiency. These trends aim to streamline and shorten the overall downstream processing timeline, leading to increased productivity and cost savings.
Global Downstream Processing Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates and Analyses the Data collected by means of Primary Exploratory Research backed by the robust Secondary Desk research.
According to our analyses, the market is highly competitive, with key players focused on innovation, expanding their product portfolios, and enhancing customer support. As the biopharmaceutical industry continues to evolve, the downstream processing market is expected to play a vital role in enabling the production of high-quality and safe biopharmaceutical products. The downstream processing market has been experiencing steady growth in recent years. Factors such as the increasing demand for biopharmaceuticals, advancements in biotechnology, and the need for high-quality and purified products drive market growth. The market size is expected to expand further as the biopharmaceutical industry continues to grow and new therapies, including advanced cell and gene therapies, gain traction.
| Report Metric | Details |
|---|---|
| Market size value in 2023 | USD 30.98 billion |
| Market size value in 2031 | USD 110.79 billion |
| Growth Rate | 15.21% |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
|
| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Global Downstream Processing Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Global Downstream Processing Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Global Downstream Processing Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Global Downstream Processing Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Global Downstream Processing Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Global Downstream Processing Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
Global Downstream Processing Market Report Snapshots
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