Vaccine Adjuvants Market Size, Share, Growth Analysis, By Type(Pathogen-Based Adjuvants and Particulate Adjuvants), By Route of Administration(Intramuscular Route, and Intradermal Route), By Region - Industry Forecast 2024-2031


Report ID: SQMIG35I2155 | Region: Global | Published Date: March, 2024
Pages: 219 |Tables: 60 |Figures: 75

Vaccine Adjuvants Market Insights

Global Vaccine Adjuvants Market size was valued at USD 893.23 million in 2022 and is poised to grow from USD 1018.19 million in 2023 to USD 2902.45 million by 2031, growing at a CAGR of 13.99% in the forecast period (2024-2031).

The growing prevalence of life-threatening diseases such as cervical cancer, Human Papillomavirus (HPV), HIV, and tuberculosis, has led to an increased demand for adjuvants. These adjuvants play a crucial role in enhancing the efficacy of vaccines against these infectious diseases. Furthermore, there is a rising focus on developing vaccines with long-lasting immunization effects to combat existing and emerging diseases. This emphasis on sustained protection has further fueled the demand for adjuvants in the market. Adjuvant research has become increasingly important in the development of vaccines, as innovative vaccine antigens often exhibit inadequate immunogenicity on their own. The market growth is also attributed to the increasing utilization of recombinant and synthetic vaccines. These advanced vaccines rely on adjuvants to enhance their effectiveness, thereby driving the expansion of the market in the upcoming years. Major players in the industry are actively involved in the discovery and development of new adjuvants to combat fatal diseases. Notably, there are promising products like AS01, ISCOM & ISCOMMATRIX, and AS02 that are currently undergoing clinical trials. The introduction of these pipeline drugs is expected to further propel the market growth. In the United States, a developed country with a significant population and a high influx of travelers, the demand for immunization is substantial. This demand is primarily driven by the need to ensure the safety and well-being of the local population. Moreover, favorable government initiatives aimed at immunizing people against serious diseases are anticipated to contribute to market growth. An example of such an initiative is the program initiated by the National Institute of Allergy and Infectious Diseases, which focuses on advancing the development and utilization of adjuvants for human use.

Market Snapshot - 2024-2031

Global Market Size

USD 893.23 million

Largest Segment

Pathogen-Based Adjuvants

Fastest Growth

Pathogen-Based Adjuvants

Growth Rate

13.99% CAGR

Global Vaccine Adjuvants Market ($ Bn)
Country Share for North America Region (%)

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Vaccine Adjuvants Market Segmental Analysis

Global Vaccine Adjuvants Market is segmented by type, route of administration, and region. Based on type, the market can be segmented into pathogen-based adjuvants, and particulate adjuvants. Based on route of administration, the market is segmented into intramuscular route, and intradermal route. Based on region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.

Vaccine Adjuvants Market Analysis by Type

By type, the market can be segmented into pathogen-based adjuvants and particulate adjuvants. Pathogen-based adjuvants refer to the use of whole inactivated pathogens or their components as adjuvants. These adjuvants stimulate a broad immune response by mimicking the natural infection process. Adjuvants derived from bacterial and viral pathogens, such as lipopolysaccharides (LPS), toxoids, and viral proteins, have been extensively used in vaccines for diseases like pertussis, diphtheria, hepatitis B, and influenza. With ongoing research and development efforts, new pathogen-based adjuvants are being explored to improve vaccine effectiveness. This segment is expected to maintain its dominance in the vaccine adjuvants market.

Adjuvant emulsions are oil-based substances that enhance the immune response by providing sustained release and depot effect. Dominated by oil-in-water emulsions, this segment includes well-known adjuvants like MF59® and AS03. Adjuvant emulsions have demonstrated their efficacy in vaccines for diseases like influenza, malaria, and herpes zoster. They are known for promoting a strong and durable immune response. With the increasing demand for vaccine formulations with improved immunogenicity, the adjuvant emulsion segment is expected to witness steady growth.

Vaccine Adjuvants Market Analysis by Route of Administration

By route of administration, the market can be segmented into intramuscular route and intradermal route. The intramuscular route accounted for the largest market share in 2023 due to its ability to provide better immune specificity. This route is commonly used for administering vaccines against HPV, influenza, meningitis, and other diseases. The efficacy of vaccines heavily depends on the route of administration. For example, alum salts, which are widely used as parenteral adjuvants, are ineffective when administered orally or nasally. Therefore, the intramuscular segment dominates the market due to its proven effectiveness in eliciting a robust immune response.

The intradermal route is projected to be the fastest-growing segment in the vaccine adjuvants market. This route offers several advantages, including longer absorption time and duration of action compared to other routes. These factors contribute to increased demand for vaccines administered through the intradermal route. Some adjuvants, such as TLR3-Ligand Poly (I:C), have shown the ability to induce mucosal antibody responses and provide protection against genital HSV-2 infection when administered intradermally. The growing recognition of the intradermal route's potential in enhancing vaccine efficacy drives the rapid growth of this segment.

Global Vaccine Adjuvants Market Size By Type

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Vaccine Adjuvants Market Regional Insights

North America dominated the global vaccine adjuvants market. The United States is a developed country with a substantial population, resulting in a high demand for immunization and vaccine-related products. Additionally, the country experiences a large influx of travelers, which further emphasizes the importance of immunization to ensure public health and safety. Furthermore, the United States has a well-established healthcare infrastructure and favorable government initiatives that support immunization programs, thereby driving the demand for vaccine adjuvants.

On the other hand, the APAC region is witnessing rapid growth in the vaccine adjuvants market. Countries such as China, India, Japan, and South Korea are at the forefront of this growth. APAC is characterized by a large population, increasing disposable incomes, and rising awareness about the importance of immunization. As a result, there is a growing demand for vaccines and vaccine adjuvants to combat infectious diseases. Moreover, governments in the APAC region are taking proactive measures to improve healthcare infrastructure and implement immunization programs, further fueling the market growth. Additionally, the presence of a large number of contract research organizations and manufacturers in countries like China and India contributes to the development and production of vaccine adjuvants in the region.

Global Vaccine Adjuvants Market By Region
  • Largest
  • Fastest

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Vaccine Adjuvants Market Dynamics

Vaccine Adjuvants Market Drivers

Increasing focus on the development of innovative vaccines against emerging and existing diseases

  • One key driver for the growth of the global vaccine adjuvants market is the increasing focus on the development of innovative vaccines against emerging and existing diseases. As new infectious diseases continue to emerge and existing ones evolve, there is a growing need for vaccines with enhanced immunogenicity and long-lasting efficacy. Adjuvants play a crucial role in boosting the immune response and improving vaccine effectiveness. The demand for vaccine adjuvants is driven by the imperative to develop advanced vaccines that can effectively combat these evolving and challenging diseases.

Vaccine Adjuvants Market Restraints

Complex regulatory landscape surrounding their approval and usage

  • One significant restraint for the global vaccine adjuvants market is the complex regulatory landscape surrounding their approval and usage. Adjuvants are considered as separate entities from vaccines, requiring specific regulatory approvals and safety evaluations. The stringent regulatory processes, including extensive clinical trials and safety assessments, can significantly prolong the time-to-market for adjuvants. Moreover, there may be variations in regulatory requirements across different regions, adding further complexity and potential delays. These regulatory challenges pose obstacles to the timely introduction of new adjuvants, hindering market growth and innovation in the vaccine adjuvants industry.

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Vaccine Adjuvants Market Competitive Landscape

The global vaccine adjuvants market is characterized by a diverse range of companies striving to innovate and meet the growing demand for adjuvant products. Market players are engaged in extensive research and development activities to enhance the effectiveness and safety of adjuvants. Additionally, partnerships, collaborations, and acquisitions are common strategies adopted by companies to strengthen their market position. The competitive environment fosters a continuous drive for technological advancements, improved manufacturing processes, and the development of novel adjuvant formulations, contributing to the overall growth and competitiveness of the market.

Vaccine Adjuvants Market Top Player’s Company Profiles

  • GlaxoSmithKline plc (United Kingdom)
  • SEPPIC (France)
  • InvivoGen (US)
  • Brenntag Biosector (Denmark)
  • Avanti Polar Lipids, Inc. (US)
  • Vaxine Pty Ltd. (Australia)
  • SPI Pharma (US)
  • OZ Biosciences (France)
  • CureVac AG (Germany)
  • Adjuvatis (France)
  • Advanced BioAdjuvants Corporation (US)
  • Adjuvance Technologies Inc. (US)
  • SDA Bio (Italy)
  • Bio Products Laboratory Ltd. (United Kingdom)
  • GSK Vaccines GmbH (Germany)
  • Mucosis B.V. (Netherlands)
  • NanoBio Corporation (US)

Vaccine Adjuvants Market Recent Developments

  • In March 2024, Croda International entered a collaboration agreement with the Access to Advanced Health Institute (AAHI) to innovate and develop vaccine adjuvant formulations.

  • In February 2024, the United States’ Defense Threat Reduction Agency's (DTRA) Joint Science and Technology Office (JSTO) for the Chemical and Biological Defense (CBD) Program has awarded a 5-year contract totaling up to $31 million including program options to the team of Ginkgo Bioworks Inc. and SaponiQx, Inc. (a subsidiary of Agenus Inc.) to discover and develop next-generation vaccine adjuvants.

  • In November 2023, Novavax, Inc., a global company advancing protein-based vaccines with its Matrix-M™ adjuvant, announced that Nuvaxovid™ XBB.1.5 COVID-19 Vaccine (NVX-CoV2601) has been granted Emergency Use Listing (EUL) by the World Health Organization (WHO) for active immunization to prevent COVID-19 in individuals aged 12 and older.

Vaccine Adjuvants Key Market Trends

  • The rising need for innovative adjuvant formulations is a significant trend in the world market for vaccine adjuvants. As there is a greater need for effective vaccines, researchers are creating and implementing cutting-edge adjuvant technologies to improve vaccine efficacy and durability. The use of cutting-edge adjuvant substances and delivery technologies that promote potent immune responses while minimising negative effects is included in this.
  • The market's landscape is also changing as more attention is being paid to creating adjuvants for next-generation vaccines, such as those that fight cancer immunotherapy and emerging infectious illnesses. This achievement demonstrates the industry's dedication to advancing vaccine research, which is fueling the expansion of the worldwide vaccine adjuvants market.

Vaccine Adjuvants Market SkyQuest Analysis

SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.

According to our global vaccine adjuvants market analysis, the rising prevalence of infectious diseases, including cervical cancer, Human Papillomavirus (HPV), HIV, and tuberculosis, along with the increasing focus on long-lasting immunization against emerging diseases, is boosting the demand for adjuvants. Inadequate immunogenicity of innovative vaccine antigens and the growing use of recombinant and synthetic vaccines further contribute to market growth. Major players are actively involved in the discovery and development of new adjuvants to combat fatal diseases. The market is dominated by North America, particularly the United States, due to its large population, high travel volume, and favorable government initiatives. The Asia-Pacific (APAC) region is experiencing rapid growth driven by a large population, increasing disposable incomes, rising awareness, and government efforts to improve healthcare infrastructure. However, the complex regulatory landscape poses a challenge to the timely introduction of new adjuvants.

Report Metric Details
Market size value in 2023 USD 893.23 million
Market size value in 2031 USD 2902.45 million
Growth Rate 13.99%
Forecast period 2024-2031
Forecast Unit (Value) USD Million
Segments covered
  • Type
    • Pathogen-Based Adjuvants and Particulate Adjuvants
  • Route of Administration
    • Intramuscular Route, and Intradermal Route
Regions covered North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA)
Companies covered
  • GlaxoSmithKline plc (United Kingdom)
  • SEPPIC (France)
  • InvivoGen (US)
  • Brenntag Biosector (Denmark)
  • Avanti Polar Lipids, Inc. (US)
  • Vaxine Pty Ltd. (Australia)
  • SPI Pharma (US)
  • OZ Biosciences (France)
  • CureVac AG (Germany)
  • Adjuvatis (France)
  • Advanced BioAdjuvants Corporation (US)
  • Adjuvance Technologies Inc. (US)
  • SDA Bio (Italy)
  • Bio Products Laboratory Ltd. (United Kingdom)
  • GSK Vaccines GmbH (Germany)
  • Mucosis B.V. (Netherlands)
  • NanoBio Corporation (US)
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Table Of Content

Executive Summary

Market overview

  • Exhibit: Executive Summary – Chart on Market Overview
  • Exhibit: Executive Summary – Data Table on Market Overview
  • Exhibit: Executive Summary – Chart on Vaccine Adjuvants Market Characteristics
  • Exhibit: Executive Summary – Chart on Market by Geography
  • Exhibit: Executive Summary – Chart on Market Segmentation
  • Exhibit: Executive Summary – Chart on Incremental Growth
  • Exhibit: Executive Summary – Data Table on Incremental Growth
  • Exhibit: Executive Summary – Chart on Vendor Market Positioning

Parent Market Analysis

Market overview

Market size

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • SWOT Analysis

KEY MARKET INSIGHTS

  • Technology Analysis
    • (Exhibit: Data Table: Name of technology and details)
  • Pricing Analysis
    • (Exhibit: Data Table: Name of technology and pricing details)
  • Supply Chain Analysis
    • (Exhibit: Detailed Supply Chain Presentation)
  • Value Chain Analysis
    • (Exhibit: Detailed Value Chain Presentation)
  • Ecosystem Of the Market
    • Exhibit: Parent Market Ecosystem Market Analysis
    • Exhibit: Market Characteristics of Parent Market
  • IP Analysis
    • (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
  • Trade Analysis
    • (Exhibit: Data Table: Import and Export data details)
  • Startup Analysis
    • (Exhibit: Data Table: Emerging startups details)
  • Raw Material Analysis
    • (Exhibit: Data Table: Mapping of key raw materials)
  • Innovation Matrix
    • (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
  • Pipeline product Analysis
    • (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
  • Macroeconomic Indicators

COVID IMPACT

  • Introduction
  • Impact On Economy—scenario Assessment
    • Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
  • Revised Market Size
    • Exhibit: Data Table on Vaccine Adjuvants Market size and forecast 2021-2027 ($ million)
  • Impact Of COVID On Key Segments
    • Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
  • COVID Strategies By Company
    • Exhibit: Analysis on key strategies adopted by companies

MARKET DYNAMICS & OUTLOOK

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • Regulatory Landscape
    • Exhibit: Data Table on regulation from different region
  • SWOT Analysis
  • Porters Analysis
    • Competitive rivalry
      • Exhibit: Competitive rivalry Impact of key factors, 2021
    • Threat of substitute products
      • Exhibit: Threat of Substitute Products Impact of key factors, 2021
    • Bargaining power of buyers
      • Exhibit: buyers bargaining power Impact of key factors, 2021
    • Threat of new entrants
      • Exhibit: Threat of new entrants Impact of key factors, 2021
    • Bargaining power of suppliers
      • Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
  • Skyquest special insights on future disruptions
    • Political Impact
    • Economic impact
    • Social Impact
    • Technical Impact
    • Environmental Impact
    • Legal Impact

Market Size by Region

  • Chart on Market share by geography 2021-2027 (%)
  • Data Table on Market share by geography 2021-2027(%)
  • North America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • USA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Canada
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Europe
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Germany
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Spain
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • France
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • UK
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Europe
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Asia Pacific
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • China
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • India
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Japan
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Korea
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Asia Pacific
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Latin America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Brazil
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of South America
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Middle East & Africa (MEA)
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • GCC Countries
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Africa
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of MEA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)

KEY COMPANY PROFILES

  • Competitive Landscape
    • Total number of companies covered
      • Exhibit: companies covered in the report, 2021
    • Top companies market positioning
      • Exhibit: company positioning matrix, 2021
    • Top companies market Share
      • Exhibit: Pie chart analysis on company market share, 2021(%)

Methodology

For the Vaccine Adjuvants Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:

1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.

2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Vaccine Adjuvants Market.

3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.

4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.

Analyst Support

Customization Options

With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Vaccine Adjuvants Market:

Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.

Regional Analysis: Further analysis of the Vaccine Adjuvants Market for additional countries.

Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.

Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.

Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.

Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.

Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.

Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.

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FAQs

Vaccine Adjuvants Market size was valued at USD 893.23 million in 2022 and is poised to grow from USD 1018.19 million in 2023 to USD 2902.45 million by 2031, growing at a CAGR of 13.99% in the forecast period (2024-2031).

The vaccine adjuvants market is characterized by a diverse range of companies striving to innovate and meet the growing demand for adjuvant products. Market players are engaged in extensive research and development activities to enhance the effectiveness and safety of adjuvants. Additionally, partnerships, collaborations, and acquisitions are common strategies adopted by companies to strengthen their market position. The competitive environment fosters a continuous drive for technological advancements, improved manufacturing processes, and the development of novel adjuvant formulations, contributing to the overall growth and competitiveness of the market. 'CSL Limited (Australia)', 'GlaxoSmithKline plc (United Kingdom)', 'Novavax, Inc. (US)', 'SEPPIC (France)', 'Agenus Inc. (US)', 'InvivoGen (US)', 'Brenntag Biosector (Denmark)', 'Avanti Polar Lipids, Inc. (US)', 'Vaxine Pty Ltd. (Australia)', 'SPI Pharma (US)', 'OZ Biosciences (France)', 'CureVac AG (Germany)', 'Adjuvatis (France)', 'Advanced BioAdjuvants Corporation (US)', 'Adjuvance Technologies Inc. (US)', 'SDA Bio (Italy)', 'Bio Products Laboratory Ltd. (United Kingdom)', 'GSK Vaccines GmbH (Germany)', 'Mucosis B.V. (Netherlands)', 'NanoBio Corporation (US)'

One key driver for the growth of the vaccine adjuvants market is the increasing focus on the development of innovative vaccines against emerging and existing diseases. As new infectious diseases continue to emerge and existing ones evolve, there is a growing need for vaccines with enhanced immunogenicity and long-lasting efficacy. Adjuvants play a crucial role in boosting the immune response and improving vaccine effectiveness. The demand for vaccine adjuvants is driven by the imperative to develop advanced vaccines that can effectively combat these evolving and challenging diseases.

The rising need for innovative adjuvant formulations is a significant trend in the world market for vaccine adjuvants. As there is a greater need for effective vaccines, researchers are creating and implementing cutting-edge adjuvant technologies to improve vaccine efficacy and durability. The use of cutting-edge adjuvant substances and delivery technologies that promote potent immune responses while minimising negative effects is included in this.

North America dominated the vaccine adjuvants market. The United States is a developed country with a substantial population, resulting in a high demand for immunization and vaccine-related products. Additionally, the country experiences a large influx of travelers, which further emphasizes the importance of immunization to ensure public health and safety. Furthermore, the United States has a well-established healthcare infrastructure and favorable government initiatives that support immunization programs, thereby driving the demand for vaccine adjuvants.

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