Oncolytic Virus Therapy Market
Report ID: SQMIG35H2403
Report ID: SQMIG35H2403
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Report ID:
SQMIG35H2403 |
Region:
Global |
Published Date: January, 2026
Pages:
184
|Tables:
67
|Figures:
68
Global Oncolytic Virus Therapy Market size was valued at USD 411.4 million in 2024 and is poised to grow from USD 517.13 million in 2025 to USD 3223.16 million by 2033, growing at a CAGR of 25.7% during the forecast period (2026-2033).
The growing number of cancer cases, the rising interest in the potential advantages of oncolytic virus therapy, the development of new imaging technologies, and other factors will continue to contribute to the future expansion of the oncolytic virus therapy industry.
With an increase in the number of cancer cases worldwide, there is an increasing demand for more effective, targeted treatment regimens. As such, the demand for additional financial resources for R&D is on the rise, allowing more researchers to find and develop new oncolytic viruses with improved therapeutic properties. Other key indicators supporting the continued advancement of the oncolytic virus treatment industry are the numerous ongoing clinical trials occurring worldwide demonstrating a variety of successful applications of oncolytic virus therapy and gaining attention from pharmaceutical manufacturers and other healthcare providers. Additionally, the endorsement of oncolytic virus therapy by regulatory agencies (e.g., FDA, EMA) is also displaying increased confidence in the use of oncolytic virus therapy in health care. The above-mentioned trends are helping to drive market growth and increased market penetration in developed countries.
However, the market is also being impacted by several challenges, including high costs associated with treatment, potential risk associated with therapies, and slow regulatory approvals in many areas, and thus, the potential for side effects associated with treatments.
How is the Oncolytic Virus Therapy Market Responding to the Rising Global Cancer Burden?
The oncolytic virus therapy sector is expanding strongly due to a growing number of people diagnosed with cancer around the world. These methods involve using genetic engineering techniques to create modified viruses that work specifically to infect and destroy only cancerous cells while leaving other parts of the body unharmed, allowing for a more precise and less toxic method of treatment for those suffering from this disease. Cancer is quickly becoming a leading cause of death throughout the world, thus creating opportunities for healthcare professionals and companies involved in biopharmaceutical development to invest large amounts of time and money into medical research and clinical trials of the available therapies. As a result of these investments, regulatory agencies, such as the FDA (Food and Drug Administration), are providing more rapid pathways for oncolytic virus treatments to enter the market and gain patient access. The combination of these factors is creating tremendous momentum for market growth and providing patients with new therapeutic options. As a result, the market is transitioning towards new methods of personalizing cancer treatment plans through innovative therapeutic options.
Market snapshot - 2026-2033
Global Market Size
USD 142.81 Million
Largest Segment
HSV
Fastest Growth
Adenoviruses
Growth Rate
23.6% CAGR
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Global Oncolytic Virus Therapy Market is segmented by Virus Type, Cancer Type, Therapy Type, Route of Administration, End User and region. Based on Virus Type, the market is segmented into Adenovirus, Herpes Simplex Virus, Reovirus, Vaccinia Virus and Others. Based on Cancer Type, the market is segmented into Melanoma, Lung Cancer, Breast Cancer, Colorectal Cancer and Others. Based on Therapy Type, the market is segmented into Monotherapy and Combination Therapy. Based on Route of Administration, the market is segmented into Intratumoral and Intravenous. Based on End User, the market is segmented into Hospitals, Specialty Clinics and Research Institutes. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.
HSV (Herpes Simplex Virus) dominates with the largest oncolytic virus therapy market share, due to its strong ability to selectively infect and destroy cancer cells while sparing healthy tissues. Its genetic flexibility allows researchers to add immune-stimulating agents, making it highly effective for various cancers. The success of HSV-based therapies in clinical trials and regulatory approvals has further strengthened its position as the most widely used virus type in the industry.
Meanwhile, adenoviruses are the fastest-growing segment in the oncolytic virus therapy market. Their easy genetic modification, broad tissue targeting, and promising results in early-stage cancer treatments are fuelling demand. These viruses are gaining attention for their potential in combination therapies and are being explored across multiple tumour types.
Melanoma leads the oncolytic virus therapy market, accounting for the largest share due to the proven success of treatments like T-VEC (talimogene laherparepvec) which was specifically approved for advanced melanoma. The high responsiveness of melanoma to immune-based therapies, along with increased R&D funding and early clinical success, has made it the primary focus area for many biotech firms developing oncolytic viruses.
Meanwhile, breast cancer is emerging as the fastest-growing application segment. Rising global breast cancer cases and the push for personalized, less toxic treatments are encouraging more clinical trials using oncolytic viruses. Researchers are exploring ways to combine these therapies with immunotherapy and chemotherapy, making it a highly promising area for future growth.
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North America leads the global oncolytic virus therapy market due to its advanced biotechnology ecosystem, the world’s highest healthcare expenditure, and rapid adoption of innovative cancer treatments. Strong research infrastructure, substantial government and private funding, favorable regulatory pathways, and the presence of leading biopharmaceutical companies further support early clinical development, commercialization, and widespread use of oncolytic virus–based cancer therapies across the region.
The United States has the largest market for oncolytic virus therapy (OVT) in North America. This is due to its large patient base, state-of-the-art clinical research organizations, and a very favorable regulatory environment. Companies such as Amgen and Oncolys BioPharma are leading the way in OVT development, with several approved products like T-VEC.
Canada’s market is expanding because of the Canadian government’s increasing support of cancer research initiatives, healthcare innovations and collaboration with strategic biotech companies. Many Canadian institutions are engaged in the early-stage development and clinical testing of virus-based therapies, particularly for rare and challenging to treat forms of cancer. Companies such as Turnstone Biologics are seeing great success with innovative oncolytic virus platforms using immune modulating agents.
The Asia Pacific region is becoming a focus for oncolytic virus therapy businesses because of its rapidly increasing numbers of cancer patients, growing biopharmaceutical infrastructure, and supportive clinical trials. Countries, including China and Japan, South Korea, and India, are investing substantially in researching cancer and developing personalized medicine.
The market for oncolytic virus therapies in Japan is expanding due to Japan's robust pharmaceutical market, the number of senior citizens with increasing cancer rates in Japan, and the Japanese researchers and biomedical firms involved in the clinical development of engineered viruses (including engineered viruses for treating liver cancer, gastric cancers, and breast cancers). Furthermore, the Japanese Government's initiatives to expedite the approval process for drugs and provide funding for cutting-edge solutions for cancer have contributed to an environment conducive to developing and marketing this therapeutic modality.
The oncolytic virus therapy products in South Korea are evolving rapidly based on South Korea's advanced biotechnology environment and high-tech research facilities and personnel. Additionally, South Korea has a strong emphasis on treating patients with personalized medicine methods, and there is much interest in oncolytic viruses in both the public and private sectors.
The emergence of Europe as an attractive region for oncolytic virus therapy companies can be attributed to the increasing number of people diagnosed with cancer, as well as a strong infrastructure for clinical research and commitment to personalized treatments. The countries of Germany, the UK, and France, among others, have a long-standing history of creating supportive regulatory environments, funding biotech innovation, and encouraging academic institutions and industry partners to work together.
With regard to oncolytic virus therapy market growth, the UK trends are supported by the biotechnology industry and world-renowned research facilities, as well as health strategies centered on cancer care. It is expected that organizations like PsiOxus Therapeutics will pave the way for the development of new oncolytic viruses aimed at solid tumors through collaborations with established pharmaceutical companies.
The oncolytic virus therapy market regional outlook in Germany continues to expand due to the rapid growth of the country's medical technology industry, the increasing incidence of cancer diagnoses, and the widespread availability of government-sponsored research programs, all of which provide support for research and development in the biotech field. As a result, German biotech companies and educational institutions are very active in the generation of next-generation oncolytic virus therapies. Research initiatives are being designed to generate novel treatments through enhancements of the immune system and specific targeting of cancer tumors.
Over the last few years, France has begun to develop a strong foothold in the oncolytic virus therapy industry. The rapid growth of the French biotechnology industry, along with local companies like Transgene's development of innovative virus-based immunotherapies for multiple cancers, will continue to drive the country's growth within the oncolytic virus therapy market.
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Rising Cancer Cases Globally
Growing Interest in Targeted and Immune-Based Therapies
High Treatment Costs
Limited Awareness and Accessibility
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The oncolytic virus therapy industry should concentrate on bolstering the safety, precision and scale of genetically engineered viruses to improve the effectiveness of various treatments for cancer. In addition to that, the companies need to improve clinical validation, implement a custom approach to therapy, and incorporate patient immune systems into their new drugs as a response to the increasing demand for cancer therapies that are targeted. The oncolytic virus therapy firms also must collaborate with regulatory agencies to establish streamlined approval channels and increase access to treatments for the growing number of patients who are being treated as a part of global clinical research trials. In addition to these initiatives, investing in partnerships with academia, utilizing AI to develop drugs more efficiently, and developing new manufacturing technologies will all increase the potency of a new drug's use in the market and decrease the time it takes for each drug to reach patients and get approved.
There are several start-up companies currently working to bring oncolytic viruses as a cancer treatment through novel virus-based immunotherapies to treat difficulty reaching cancers. Below are some examples of start-ups that have a significant impact globally on the demand for the oncolytic virus therapy marketplace.
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
As per SkyQuest analysis, the increasing occurrence of cancer cases worldwide and the greater focus on precision medicine has spurred future growth in the oncolytic virus therapy market. In conjunction with increasing numbers of targeted and immune activating treatments, there has been an ongoing effort to create genetically modified viruses capable of selectively destroying cancerous cells and stimulating immune responses. Continued improvements in genetic engineering technology and supportive government regulation have facilitated the increased development of oncolytic virus therapies through clinical research and approval processes. Some limitations could slow down Global access to these types of treatments due to high cost associated with treatment, limited knowledge about these treatments and unequal access to oncolytic virus therapy around the World. Continued development of new innovative therapies to treat all types of cancer will be necessary to keep pace with the increasing number of clinical trial opportunities being offered by multiple companies in the oncolytic virus therapy market across the globe.
| Report Metric | Details |
|---|---|
| Market size value in 2024 | USD 411.4 million |
| Market size value in 2033 | USD 3223.16 million |
| Growth Rate | 25.7% |
| Base year | 2024 |
| Forecast period | 2026-2033 |
| Forecast Unit (Value) | USD Million |
| Segments covered |
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| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
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| Customization scope | Free report customization with purchase. Customization includes:-
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Table Of Content
Executive Summary
Market overview
Parent Market Analysis
Market overview
Market size
KEY MARKET INSIGHTS
COVID IMPACT
MARKET DYNAMICS & OUTLOOK
Market Size by Region
KEY COMPANY PROFILES
Methodology
For the Oncolytic Virus Therapy Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Oncolytic Virus Therapy Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
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Global Oncolytic Virus Therapy Market size was valued at USD 142.81 Million in 2023 and is poised to grow from USD 187.05 Million in 2024 to USD 1082.74 Million by 2032, growing at a CAGR of 23.6% during the forecast period (2025-2032).
The oncolytic virus therapy industry should concentrate on bolstering the safety, precision and scale of genetically engineered viruses to improve the effectiveness of various treatments for cancer. In addition to that, the companies need to improve clinical validation, implement a custom approach to therapy, and incorporate patient immune systems into their new drugs as a response to the increasing demand for cancer therapies that are targeted. The oncolytic virus therapy firms also must collaborate with regulatory agencies to establish streamlined approval channels and increase access to treatments for the growing number of patients who are being treated as a part of global clinical research trials. In addition to these initiatives, investing in partnerships with academia, utilizing AI to develop drugs more efficiently, and developing new manufacturing technologies will all increase the potency of a new drug's use in the market and decrease the time it takes for each drug to reach patients and get approved. 'Amgen', 'Oncolytics Biotech ', 'Viralytics ', 'Transgene SA ', 'Oncolys BioPharma ', 'Targovax ', 'PsiOxus Therapeutics ', 'Sorrento Therapeutics ', 'Lokon Pharma ', 'Genelux Corporation ', 'Vyriad ', 'TILT Biotherapeutics ', 'Cold Genesys '
With an ever-increasing number of cancers diagnosed worldwide, a significant factor contributing to the growth in demand for oncolytic (virus) therapies is the general demand for more precise and effective means of treatment. Traditional therapies such as chemotherapy and radiation have a limitation and provide an avenue for patients and their doctors towards alternative therapies, specifically therapies that target cancer cells directly while enhancing the immune system. Oncolytic viruses directly attack the cancer cell itself and produce a reaction in the body that enables the immune system to develop against the virus and the cancer simultaneously.
Advancement of Genetic Engineering: Dramatic improvements in the field of genetic engineering are facilitating the development of oncolytic virus therapies market trends, by allowing researchers to engineer viruses to selectively attack and kill only cancerous cells while leaving uninjured surrounding healthy cells. Additionally, engineered viruses can provide additional immune enhancement through the invention of inserting either cytokines (a type of cell signaling molecule) or checkpoint inhibitors (a way to “turn on” or “turn off” T-cell activity). As the use of more sophisticated and accurate technologies continues to improve, scientists are discovering new ways to create and utilize oncolytic therapies, including in the Clinic of Cancer Treatment in real-time.
Why North America Leads Oncolytic Virus Therapy Market on a Global Level?
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