Top Cancer Immunotherapy Companies

Skyquest Technology's expert advisors have carried out comprehensive research and identified these companies as industry leaders in the Cancer Immunotherapy Market. This Analysis is based on comprehensive primary and secondary research on the corporate strategies, financial and operational performance, product portfolio, market share and brand analysis of all the leading Cancer Immunotherapy industry players.

Cancer Immunotherapy Market Competitive Landscape

Various factors are stimulating the strong growth of this global cancer immunotherapy market, with the rising incidences of cancer itself being a major one, plus advances in immunotherapy research, and finally, acceptance of these new biologic drugs. Immunotherapy is becoming increasingly more popular as these novel treatments obtain regulatory approval and become widely accessible to patients. Advances in technology and increased R&D funding by the pharmaceutical companies sustain this growth path. This page will discuss how the rise in cancer incidence, the entry of novel drugs, and technological advancement are impacting the market's growth and performance.

Industry Overview

According to SkyQuest Technology “Cancer Immunotherapy Market By Type (Monoclonal Antibodies, Cancer Vaccines, Checkpoint Inhibitors, and Immunomodulators) By Route of Administration (Intravenous (IV), Intramuscular, and Oral), By Application, By End User, By Region - Industry Forecast 2026-2033,” rapidly expanding in the realm of cancer immunotherapy are monoclonal antibodies (mAbs). Their use has been widespread due to their ability to selectively home in on cancer cells, while sparing almost all normal cells.

Top 10 Global Cancer Immunotherapy Companies

Company

Est. Year

Headquarters

Revenue

Key Services

Merck & Co., Inc.

1891

Rahway, New Jersey, USA

USD 64.2 Billion (2025)

Global biopharma leader developing cancer immunotherapies such as Keytruda (PD1 inhibitor) and other oncology and vaccine products. It also provides vaccines, diagnostics, and animal health products.

Bristol-Myers Squibb Company

1887

Princeton/Lawrenceville, New Jersey, USA

Approximately USD 48 Billion (2025)

Develops and markets cancer immunotherapies including Opdivo and Yervoy, along with therapies for autoimmune diseases and cardiovascular conditions.

F. Hoffmann-La Roche AG

1896

Basel, Switzerland

NA

Global healthcare company focusing on oncology immunotherapies, diagnostics, personalized medicine, and other therapeutic areas; strong diagnostics division complements drug development.

AstraZeneca plc

1999

Cambridge, UK

USD 13.59 Billion (2025)

Develops and commercializes oncology and immunotherapy drugs, cardiovascular, respiratory, and rare disease medicines.

Regeneron Pharmaceuticals, Inc.

1988

Tarrytown, New York, USA

NA

Biotech company focused on innovative monoclonal antibodies and biologics for oncology, immunology, and rare diseases; products include Libtayo (cancer immunotherapy).

Gilead Sciences, Inc.

1987

Foster City, California, USA

USD 7.8 Billion (2025)

Biopharmaceutical company developing medicines in HIV, oncology, liver disease, and inflammation; cancer therapy sales contributing alongside core therapeutic areas.

Novartis AG

1996

Basel, Switzerland

USD 56.37 Billion (2025)

Global healthcare leader with cancer immunotherapy and targeted therapy portfolios; also engages in neuroscience, cardiovascular, and gene therapy.

Pfizer Inc.

1849

New York City, New York, USA

USD 61.0 to USD 64.0 Billion (2025)

Develops and markets pharmaceuticals and vaccines, including oncology, immunology, rare diseases, and vaccines, with oncology portfolio contributing significantly to revenues.

Amgen Inc.

1980

Thousand Oaks, California, USA

USD 35.0 Billion to USD 36.6 Billion

Biopharmaceutical products for oncology (e.g., Kyprolis), bone health, cardiovascular and autoimmune diseases; active clinical pipeline across multiple therapies.

Johnson & Johnson

1886

New Brunswick, New Jersey, USA

NA

Diversified healthcare company with pharmaceutical (oncology and immunology), medical devices, and consumer health segments; oncology assets such as Darzalex contribute to strong growth.

1. Merck & Co., Inc.

Merck & Co., the global leader in cancer immunotherapy, uses its PD-1 inhibitor, Keytruda, to effectively treat a wide range of cancers, including melanoma, lung, and head and neck cancers. The company has undertaken a spate of research wits, clinical trials, and combinations for massive market access. The vast geographic spread of Merck and full partnerships with the hospitals and research institutions fully guarantee patient access. Innovations backed up by constant approvals give Merck the potential of a major key player in the global cancer immunotherapy industry.

2. Bristol-Myers Squibb Company

Both Opdivo and Yervoy, well-known products of Bristol-Myers Squibb, take a major part of the immunotherapy market as they are used in the treatment of different cancers, namely, lung, kidney, and melanoma cancers. Currently, the focus of their approach has been on combination medicines and international oncology alliances to create high grounds into developed and emerging countries. Starting in 2025, BMS is on a favorable trajectory toward maintaining and accentuating its position in immunotherapy markets, supporting growth in revenues and market penetration through continued R&D investment, clinical pipeline extension, and robust representation in hospitals and specialty clinics.

3. F. Hoffmann-La Roche AG

Roche leads the charge in cancer immunotherapy-the growth area in which it has entered lung cancer, breast cancer, and urothelial cancer-using its checkpoint inhibitor medicine Tecentriq (atezolizumab) along with the rest of the range. But what makes the company stand out is its offering of therapeutic and diagnostic products combined with personalized medicine. An impressive cancer pipeline, strong strategic alliances, and extensive geographical reach all work to enhance access to patients. Hence, thus making Roche the most committed innovation in research through regulatory clearances and clinical trials in broad immunotherapies, Lumiere position in becoming a key market contributor to the expansion and transformation of cancer treatment technologies.

4. AstraZeneca plc

AstraZeneca develops drugs such as Imfinzi (durvalumab) and other immuno-oncology agents directed toward head and neck, bladder, and lung malignancies. The company is extremely active in conducting clinical studies, combination medicines, and partnerships with hospitals and research centers. Its global reach, which includes Europe, North America, and Asia-Pacific, will ensure extensive availability. AstraZeneca's discovery, regulatory approvals, and incorporation of novel immunotherapies into conventional treatment regimens present the company as one of the greatest contributors to the specificity of the international cancer immunotherapy field.

5. Regeneron Pharmaceuticals, Inc.

With Libtayo (cemiplimab) envisaging its applications in lung, skin, and several other malignancies, Regeneron is a progressive name in immunotherapy. The company has high priorities placed on monoclonal antibody development, biotechnological innovation, and vigorous clinical pipelines. Expansion of patient access occurs through cooperation with pharmaceutical companies and hospitals. Regeneron is expected to grow rapidly as an emerging player in North America and Europe by its focus on research and development, targeted therapies, and combination methods, thereby contributing to the expansion and wider use of groundbreaking cancer immunotherapy methods in markets.

6. Gilead Sciences, Inc.

Gilead has an oncology and immunotherapy portfolio focused on the treatment of solid tumors and what it calls blood malignancies. The company has a focus on antibody-drug conjugates and cell therapy, especially CAR-T. While Gilead rapidly modifies the cancer treatment landscape with some clever acquisitions, it is also open to new and innovative disciplines of research and development. A worldwide distribution network, collaborations with hospitals and specialty clinics, and funding of clinical trials guarantee patient access to the company's products. In turn, Gilead's personalized therapeutics and breakthroughs in immunooncology have some of the most significant impacts on the growth and technical improvement of the cancer immunotherapy industry.

7. Novartis AG

The CAR-T treatment Kymriah and other checkpoint inhibitors targeting solid tumors and hematologic cancers Novartis is offering will build momentum for Novartis. The firm aims at cell therapy with personalized medicine and international partnerships to ensure that its therapies reach patients anywhere in the world. Novartis encourages such innovation through strongly supported clinical pipelines, continuous R&D, and partnership with medical facilities and academia. Novartis's commitment is at the core of this extremely broad application of immunotherapy in both the developed and emerging economies that stands to carve for the company facilitation of the whole cancer immunotherapy business on a global size.

8. Pfizer, Inc.

Using combination therapies and checkpoint inhibitors that target different types of cancer, Pfizer propels growth in cancer immunotherapy. The company uses clinical trials, a worldwide distribution network, and strategic partnerships to increase accessibility and promote adoption. Even quicker innovations are generated from Pfizer's tremendous cancer pipeline, major R&D investments, and partnerships with biotech companies. By incorporating immunotherapy into the routine standard of care and heavily investing in education for patients, Pfizer is becoming a major international player in revenue generation and technology advancement.

9. Amgen, Inc.

Amgen developing treatments toward cancer immunotherapy contributes with products such as Kyprolis and more biologics intended for hematologic malignancies. Amgen's dedication to monoclonal antibodies, bispecifics, and its R&D pipelines drives innovation. The company further emphasizes seamless partnerships with medical centers, academic institutions, and biotech companies to broaden the scope of treatment. This only means that the company thus invests with a strong position as one of the market players to further increase the adoption of immunotherapy and advanced strategies in treating cancer by its uncompromising commitment to clinical trials for drug development and patient access worldwide.

10. Johnson & Johnson

In addition to other diseases, Johnson & Johnson's Janssen Pharmaceuticals also contributes to its field of immunotherapy with such products as Darzalex for multiple myeloma. Their strategy includes funding R&D, clinical studies, and establishing international alliances to improve the access of patients. They also promote biotechnology medicine and combo medicines as part of integrated oncology care, which will include broad access. One of the leaders in cancer immunotherapy, J&J, promotes development and technological breakthroughs around the world with its significant size, innovative product pipeline, and commitment to oncology.

Other Leading Global Cancer Immunotherapy Companies

  • BioNTech SE
  • Moderna, Inc.
  • Exelixis, Inc.
  • Incyte Corporation
  • Sanofi S.A.
  • Zai Lab Limited
  • Kura Oncology, Inc.

Conclusion

The global cancer immunotherapy market will experience a momentous leap on a global scale. In fact, the increase in the incidences of cancers, the onslaught of newer modalities of treatment, and the easy access of patients to other avenues have been some of the major reasons for this upsurge. Possible big companies like Merck, BMS, Roche, and Novartis continue to propel and improve treatment outcomes in several cancers beyond common approaches with checkpoint inhibitors, CAR-T treatments, and in combination with other methods. Such increased R&D, regulatory approvals, and strategic alliances have pressured technological advancement and business expansion. As awareness increases and acceptance of more new medicines continues to become an international phenomenon, so does the accumulation of global investments in healthcare. Thus, the market is likely to solidify its position for cancer treatment in the whole world.

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FAQs

Personalized immunotherapy is becoming popular as countries globally provide funding for precision medicine initiatives. The United States National Cancer Institute provided more than USD 45 million in 2024 for immunotherapy research in the area of genomics that has allowed personalized treatments to improve treatment effectiveness and reduce toxicity. The advancements needed to create personalized immunotherapy treatment options will improve care for patients internationally.

The market for cancer immunotherapy is projected to have a compound annual growth rate of 9.0% from 2025 to 2032, with the growth drivers including the increase in cancer incidence, technology improvements and growing demand for targeted immuno-oncology therapies.

The main types are Monoclonal Antibodies, Cancer Vaccines, Checkpoint Inhibitors and Immunomodulators. Each has a different mechanism of enhancing the immune system's capabilities to recognize and destroy cancer cells.

Monoclonal antibodies target cancer cells with higher specificity while largely sparing normal tissues. Monoclonal antibodies are the fastest growing segment of cancer immunotherapy due to their specificity and the advancement of breakthroughs spearheaded by the government, such as Amgen's Imdelltra.

Cancer vaccines provide the means to stimulate the immune system to recognize and attack cancer cells. Many initiatives are backed to support cancer vaccine developments, like the NHS Cancer Vaccine Launch Pad in the UK, and highlight the emergence of cancer vaccines as part of advanced-stage cancer treatments - melanoma in particular.

Immunotherapy is a conventional treatment across all lung, breast, colorectal, melanoma, prostate, and hematologic cancers, especially when conventional treatments show less effect or have limited efficacy for patients.

The main end-users are Hospitals & Clinics, Cancer Research Centers, and Others. While hospitals and research institutions play the largest role in providing treatment, both groups play a vital role in advancing innovation in cancer therapy with immunotherapy.

Cancer research centers are advancing beyond shared intellectual property, through clinical trials, R&D and strategies for collaboration, all supported by public-private funding sources. Their research and development encourages next generation therapies, such as CAR-T, and innovative personalized cancer vaccines.

Typically, governments are able to hasten drug approvals through regulatory agencies like the FDA and EMA and their requests for immunotherapies and funding for clinical trials, which improves access and accelerates the market by eliminating barriers through the use of regulations and funding grants.

North America is a leader in this sector as it is home to significant healthcare infrastructure, high levels of investment in R&D, and incentives and support from regulators. The United States and its numerous biotech hubs and approvals from the FDA, especially with Keytruda and its recent expansion, is a major contributing factor to the region’s dominance.

Even though immunotherapy offers significant market growth potential, high costs for therapies to patients, particularly with complicated CAR-T medications, and limited access for low income areas, will slow universal acceptance and slow the growth of the global immunotherapy market.

Global Cancer Immunotherapy Market size was valued at USD 135.93 Billion in 2024 and is poised to grow from USD 147.35 Billion in 2025 to USD 280.92 Billion by 2033, growing at a CAGR of 8.4% during the forecast period (2026–2033).

The competitive environment surrounding cancer immunotherapy is rife with partnerships, research and R&D funding, and the government has become an innovation accelerator. The bigger market players (i.e., Merck, Bristol-Myers Squibb, Novartis) are branching out into new discovery pipelines through public-private partnerships. In 2024, the Biomedical Advanced Research and Development Authority (BARDA) provided funding of approximately USD 50 million as part of the advanced immunotherapies initiative. Multiple governments around the world including Japan MINERVA (Japan Agency for Medical Research and Development) are also funding clinical trials with advanced next generation therapies, bispecific antibodies and personalized vaccines. We are also witnessing international regulatory harmonization in the international regulatory harmonization through the International Council for Harmonisation (ICH) leading to enhanced timelines on drug approval processes alongside competitive opportunities in an international environment. 'Merck & Co., Inc. (USA)', 'Bristol-Myers Squibb Company (USA)', 'F. Hoffmann-La Roche AG (Switzerland)', 'AstraZeneca plc (UK)', 'Regeneron Pharmaceuticals, Inc. (USA)', 'Gilead Sciences, Inc. (USA)', 'Novartis AG (Switzerland)', 'Pfizer Inc. (USA)', 'Amgen Inc. (USA)', 'Johnson & Johnson (USA)', 'BioNTech SE (Germany)', 'Moderna, Inc. (USA)', 'Exelixis, Inc. (USA)', 'Alnylam Pharmaceuticals, Inc. (USA)', 'Incyte Corporation (USA)', 'Sanofi S.A. (France)', 'BeiGene, Ltd. (China)', 'Zai Lab Limited (China)', 'Fate Therapeutics, Inc. (USA)', 'Kura Oncology, Inc. (USA)'

The expansion of the global cancer immunotherapy market is fueled by the rising worldwide occurrence of diverse cancers. This surge in cancer prevalence is a key factor driving the need for inventive and efficient treatment strategies. With cancer remaining a primary cause of global morbidity and mortality, encompassing various types such as lung, breast, colorectal, melanoma, and hematological malignancies, the demand for innovative solutions is paramount. This situation highlights the significance of developing novel approaches to address the growing burden of cancer globally.

North America holds the largest share of the global cancer immunotherapy market, accounting for approximately 44.4% in 2023. This dominance is attributed to robust healthcare infrastructure, significant research funding, and favorable regulatory environments.

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Global Cancer Immunotherapy Market
Cancer Immunotherapy Market

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