USD 2.80 Billion
Bone Graft Substitutes Market Size, Share, Growth Analysis, By Type(Autografts, Allografts), By Application(Spinal Fusion, Joint Reconstruction) - Industry Forecast 2024-2031
Report ID:
SQMIG35A2257 |
Region:
Global |
Published Date: March, 2024
Pages:
219
|
Tables:
64 |
Figures:
75
Bone Graft Substitutes Market Insights
Global Bone Graft Substitutes Market size was valued at USD 2.80 Billion in 2022 and is poised to grow from USD 2.98 Billion in 2023 to USD 4.85 Billion by 2031, at a CAGR of 6.30% during the forecast period (2024-2031).
The global market for bone graft substitutes is expected to experience substantial growth during the forecast period due to increasing demand for synthetic substitutes and the approval of new products by regulatory authorities. For instance, in July 2020, Baxter obtained clearance from the U.S. FDA for its Altapore Shape Bioactive Bone Graft, expanding its bone graft substitute lineup. The adoption of bone grafts and substitutes has been driven by their advantages, such as biocompatibility, safety, and ability to promote bone healing. The demand for biocompatible bone grafts is also on the rise as they help reduce adverse reactions. Synthetic grafts containing Hydroxyapatite (HAp) and Tricalcium Phosphate (TCP) have gained popularity due to their superior biocompatibility.
The market expansion is further supported by a favorable regulatory framework and efforts by market participants to develop new products with enhanced bioactivity, biocompatibility, and mechanical properties. For example, Graftys received certification for its bone void fillers and delivery systems, while Molecular Matrix launched the Osteo-P Synthetic Bone Graft Substitute with advanced technology for bone regeneration and repair. Additionally, the increasing adoption of minimally invasive procedures is driving the demand for bone grafts and substitutes. Surgeons prefer these procedures over traditional approaches due to their benefits, including shorter recovery time, reduced hospital stays, and smaller incisions. The number of minimally invasive orthopedic procedures performed in the United States has been steadily increasing, according to data from the American Academy of Orthopedic Surgeons (AAOS). Procedures such as arthroscopy, spine surgeries, fracture repair, and joint replacement contribute to the market's significant growth pace.
US Bone Graft Substitutes Market is poised to grow at sustainable CAGR for the next forecast year.
Market snapshot - 2024-2031
Global Market Size
Largest Segment
Autografts
Fastest Growth
Autografts
Growth Rate
6.30% CAGR
Global Bone Graft Substitutes Market ($ Bn)
Country Share for North America Region (%)
Global Bone Graft Substitutes Market By Type ($ Bn)
Global Bone Graft Substitutes Market By Type (%)
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Bone Graft Substitutes Market Segmental Analysis
Global Bone Graft Substitutes Market is segmented by Type, application, and region. Based on Type, the market can be segmented into autografts, allografts, and xenografts. Based on application, the market is segmented into spinal fusion, joint reconstruction, trauma and extremities, and dental. Based on region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Bone Graft Substitutes Market Analysis by Type
By Type, the market can be segmented into autografts, allografts, and xenografts. Autografts dominated the global market due to their proven efficacy, especially in complex orthopaedic procedures. Autografts, derived from the patient's own body, are considered the gold standard in bone grafting. They have the advantage of being osteogenic, osteoinductive, and osteoconductive. Autografts provide the best chance of successful bone fusion due to their biological properties. However, autografts have limitations, such as limited availability and the need for additional surgical sites for harvesting. As a result, their usage is primarily restricted to specific cases where the patient's own bone is readily accessible.
Allografts are expected to be the fastest-growing segment due to increasing acceptance among surgeons and their expanding application across various orthopaedic and dental procedures. Allografts, which are bone grafts obtained from cadavers, have gained significant popularity in the bone graft substitutes market. These grafts are processed to remove cellular components while retaining the structural properties. Allografts serve as a scaffold for new bone formation and provide a viable alternative to autografts, overcoming the limitations associated with harvesting from the patient's own body. The availability and standardized processing of allografts make them an attractive option.
Bone Graft Substitutes Market Analysis by Application
By application, the market can be segmented into spinal fusion, joint reconstruction, trauma and extremities, and dental. Spinal fusion dominated the bone graft substitutes market, primarily due to the high number of spinal surgeries performed globally. Spinal fusion is a surgical procedure that aims to promote bone healing and fusion of vertebrae in the spine. It is one of the primary applications of bone graft substitutes. The demand for bone graft substitutes in spinal fusion is driven by factors such as the increasing prevalence of spinal disorders, such as degenerative disc disease and spinal deformities, and the rising aging population. Autografts and allografts are commonly used in spinal fusion procedures due to their osteogenic and osteoinductive properties.
While the joint reconstruction segment is the fastest growing segment in bone graft substitutes market. Joint reconstruction procedures, such as hip and knee replacements, often require the use of bone graft substitutes. These grafts are utilized to fill bone voids, enhance osseointegration, and provide structural support during the healing process. The joint reconstruction segment is driven by factors such as the growing prevalence of degenerative joint diseases, increasing demand for joint replacement surgeries, and advancements in implant technologies. Allografts and synthetic grafts are commonly employed in joint reconstruction procedures.
Global Bone Graft Substitutes Market By Type, 2023 (%)
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Bone Graft Substitutes Market Regional Insights
North America dominated the global bone graft substitutes market. The region's dominance can be attributed to several factors, including advanced healthcare infrastructure, high healthcare expenditure, favorable reimbursement policies, and extensive research and development activities. The United States, in particular, plays a major role in driving market growth in North America, with a well-established healthcare system and a large patient population. Furthermore, the presence of key market players and their focus on developing innovative bone graft substitutes contribute to the region's dominance.
On the other hand, the Asia-Pacific region is experiencing rapid growth and is considered the fastest-growing market for bone graft substitutes. APAC market growth is driven by factors such as increasing healthcare expenditure, rising awareness about the benefits of bone graft substitutes, improving healthcare infrastructure, and a growing aging population. Countries like China, Japan, and India are witnessing significant market growth due to the increasing prevalence of orthopaedic conditions, rising disposable incomes, and a shift towards advanced healthcare technologies.
Global Bone Graft Substitutes Market By Region, 2024-2031
- Largest
- Fastest
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Bone Graft Substitutes Market Dynamics
Bone Graft Substitutes Market Drivers
Increasing prevalence of orthopaedic conditions and musculoskeletal disorders
- One significant driver in the global bone graft substitutes market is the increasing prevalence of orthopaedic conditions and musculoskeletal disorders. Factors such as sedentary lifestyles, aging population, sports-related injuries, and accidents contribute to the rising incidence of fractures and bone-related ailments. As a result, there is a growing demand for effective bone graft substitutes to aid in bone regeneration and healing. This driver highlights the need for innovative solutions in the market to cater to the increasing patient pool and address the challenges associated with orthopaedic conditions.
Bone Graft Substitutes Market Restraints
High cost associated with these products
- One major restraint in the global bone graft substitutes market is the high cost associated with these products. The advanced technologies and materials used in bone graft substitutes contribute to their expensive nature. This cost factor can limit the adoption of bone graft substitutes, especially in emerging economies and regions with limited healthcare budgets. Additionally, the lack of reimbursement coverage for these products in some healthcare systems further hinders their accessibility. The high cost of bone graft substitutes poses a challenge for patients, healthcare providers, and healthcare systems seeking affordable treatment options for bone-related conditions.
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Bone Graft Substitutes Market Competitive Landscape
Global bone graft substitutes market is characterized by a diverse range of market players, including both established companies and emerging players. These players are focused on research and development activities to introduce innovative bone graft substitutes that offer enhanced biocompatibility, safety, and efficacy. Additionally, strategic collaborations, partnerships, and mergers and acquisitions are common strategies adopted by companies to strengthen their market position. The competitive landscape is driven by a continuous quest for technological advancements and the development of cost-effective solutions that cater to the evolving needs of healthcare providers and patients.
Bone Graft Substitutes Market Top Player’s Company Profiles
- Medtronic (US)
- Stryker Corporation (US)
- Johnson & Johnson (US)
- Zimmer Biomet Holdings, Inc. (US)
- Baxter International Inc. (US)
- NuVasive, Inc. (US)
- Integra LifeSciences Corporation (US)
- Wright Medical Group N.V. (Netherlands)
- Olympus Corporation (Japan)
- RTI Surgical Holdings, Inc. (US)
- AlloSource (US)
- Orthofix Medical Inc. (US)
- Bioventus LLC (US)
- SeaSpine Holdings Corporation (US)
- Xtant Medical Holdings, Inc. (US)
- Aziyo Biologics, Inc. (US)
- Coloplast Corp. (Denmark)
- Arthrex, Inc. (US)
- LifeNet Health (US)
- RTI Surgical Holdings, Inc. (US)
Bone Graft Substitutes Market Recent Developments
- In May 2023, Zimmer Biomet Holdings, Inc. announced the launch of its VIVIX 3D Printed Bone Matrix, a breakthrough bone graft substitute with a porous structure designed to mimic the natural bone environment.
- In April 2023, Stryker Corporation acquired NuVasive, Inc., a leading provider of spine surgery solutions, expanding its product portfolio in the bone graft substitutes market and strengthening its presence in the spine care segment.
- In February 2023, Osseus Fusion Systems received FDA clearance for its ARIES-TS spinal implant system, designed for use with autograft or bone graft substitutes in posterior lumbar interbody fusion (PLIF) surgeries.
- In December 2022, Kuros Biosciences announced a collaboration with Johnson & Johnson Medical Devices Companies to co-develop innovative orthobiologic solutions for bone graft substitutes and regenerative medicine.
- In September 2022, SeaSpine Holdings Corporation launched the Mariner MIS Posterior Fixation System, an innovative platform that combines pedicle screw fixation and bone grafting options for minimally invasive spinal fusion procedures.
Bone Graft Substitutes Key Market Trends
- One key market trend in the global bone graft substitutes market is the growing focus on the development of bioactive and tissue-engineered graft substitutes. These advanced graft substitutes offer improved biocompatibility and promote faster bone healing. The integration of technologies such as 3D printing and nanotechnology has enabled the creation of customized graft substitutes with enhanced structural and mechanical properties. This trend highlights the industry's commitment to innovation and the pursuit of solutions that can mimic natural bone tissue, leading to improved patient outcomes and reduced complications in bone graft procedures.
Bone Graft Substitutes Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
According to our global bone graft substitutes market analysis, the increasing demand for synthetic substitutes, coupled with rising product approvals by regulatory authorities, is driving market expansion. Advantages such as biocompatibility, safety, and osteoconductivity have further propelled the adoption of bone grafts and substitutes. North America dominated the market, benefiting from advanced healthcare infrastructure and the presence of key players. Meanwhile, the Asia-Pacific region is the fastest-growing market, driven by increasing healthcare expenditure and a growing aging population. However, the high cost of bone graft substitutes remains a restraint. The market trend focuses on developing bioactive and tissue-engineered graft substitutes to enhance biocompatibility and accelerate bone healing.
| Report Metric | Details |
|---|---|
| Market size value in 2023 | USD 2.80 Billion |
| Market size value in 2031 | USD 4.85 Billion |
| Growth Rate | 6.30% |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
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| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Bone Graft Substitutes Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Bone Graft Substitutes Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Bone Graft Substitutes Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Bone Graft Substitutes Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Bone Graft Substitutes Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Bone Graft Substitutes Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
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