USD 3.1 billion
Report ID:
SQMIG35D2295 |
Region:
Global |
Published Date: June, 2025
Pages:
198
|Tables:
90
|Figures:
71
Global Ankylosing Spondylitis Treatment Market size was valued at USD 3.1 billion in 2023 and is poised to grow from USD 3.34 billion in 2024 to USD 6.09 billion by 2032, growing at a CAGR of 7.8% during the forecast period (2025-2032).
The growing global incidence of ankylosing spondylitis (AS) among young adults and middle-aged adults is the key driver for market growth. AS is an autoimmune, progressive, chronic disorder that mainly influences the spine and sacroiliac joints to cause severe pain and disability when left untreated. Genetic factors like the HLA-B27 gene play a major role in causing regional incidence rates, especially in Europe, North America, and certain areas of Asia. With increased awareness, diagnostic capacity, and screening activities, more patients are being diagnosed earlier. With this increasing pool of patients, long-term management is required, thus increasing demand for effective and innovative treatment worldwide.
Biologic therapy has become a mainstay of ankylosing spondylitis therapy with the advantage of targeting pathways of inflammation with more specificity than conventional drugs. Tumor necrosis factor (TNF) inhibitors and interleukin-17 (IL-17) blockers are particularly useful in the reduction of spinal inflammation and arrest of disease activity. Their success in clinical trials has been followed by widespread acceptance among practitioners, enhancing patient outcomes and satisfaction. In addition, continued research is aimed at creating next-generation biologics with reduced side effects and improved delivery methods. These developments are increasing therapeutic choices, driving investment, and strengthening the significance of biologics as a key driver in market growth.
How is AI Transforming the Ankylosing Spondylitis Treatment Landscape?
Artificial intelligence (AI) is largely driving the treatment market for ankylosing spondylitis (AS) across the globe through improving accuracy of diagnosis and customizing treatment regimes. Machine learning and deep learning models in AI algorithms excel in examining voluminous data, like MRI reports, genetic marker records, and patient history files, to discover prodromes (early indication) of AS like sacroiliitis, which may fail conventional diagnostic checks. For example, AI systems have been designed to aid in diagnosing and forecasting the course of AS, particularly in areas with limited expert clinicians. This technological innovation results in earlier treatments, better patient outcomes, and a greater need for targeted treatments, thus driving market growth.
In early 2025, researchers developed VertXGradeNet, an AI-based tool to automate spinal X-ray scoring for ankylosing spondylitis (AS) based on the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). VertXGradeNet predicts mSASSS scores based on vertebral units from cervical and lumbar X-rays, with the goal of simplifying the assessment process. This development responds to the labor-intensive process of manual scoring, hopefully improving diagnostic efficiency and consistency in AS care.
Why are Startups Key to Advancing Personalized Medicine in AS Treatment?
The global ankylosing spondylitis treatment market is evolving with the emergence of tech-enabled startups over the last decade. These firms are filling gaps in diagnosis, biologics discovery, and individualized medicine. Hinging on AI, precision immunology, and new targets, startups are confronting chronic inflammation and structural damage at the molecular level. Their nimble R&D models and high-impact discoveries are accelerating treatment pipelines, rewriting traditional strategies, and expanding the global therapeutic market.
Founded in 2021, Infinimmune is a U.S. biotech start-up established in 2021, which focuses on creating fully human monoclonal antibodies with state-of-the-art single-cell immune profiling. A central product is a targeted antibody candidate for autoimmune disease such as ankylosing spondylitis, which can modulate inflammatory cytokines with high precision. Its R&D innovation is through the harvesting of native antibodies directly from healthy immune repertoires. Its platform enhances treatment specificity, lowering the side effects and accelerating the clinical pipeline towards safer, highly efficient AS treatments.
Established in the year 2020, Sudo Biosciences, launched in 2020 in the U.S., focuses on small-molecule TYK2 inhibitors for autoimmune diseases, including ankylosing spondylitis. A standout product is a selective TYK2 inhibitor focused on modulating inflammatory signaling with minimal immune suppression. Their game-changing technology—a proprietary scaffold technology for optimal kinase selectivity—lowers off-target toxicity. This cause-and-effect model facilitates safer, targeted AS therapy, particularly for patients who fail current biologics, and ensures long-term therapeutic sustainability.
Market snapshot - 2025-2032
Global Market Size
USD 3.1 billion
Largest Segment
Non-Steroidal Anti-Inflammatory Drugs
Fastest Growth
Tumor Necrosis Factor Inhibitors
Growth Rate
7.8% CAGR
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Global Ankylosing Spondylitis Treatment Market is segmented by Treatment Type, Drug Type, End-User and region. Based on Treatment Type, the market is segmented into NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), Biologics (TNF Inhibitors, IL-17 Inhibitors), DMARDs (Disease-Modifying Anti-Rheumatic Drugs), Physical Therapy & Exercise and Others. Based on Drug Type, the market is segmented into Branded Drugs and Generic Drugs. Based on End-User, the market is segmented into Hospitals & Clinics, Specialty Clinics and Home Care. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) continue to be the mainstay of ankylosing spondylitis (AS) management because of their efficacy in acute pain and inflammation reduction. Sustained-release technology and COX-2 selective inhibitors have improved patient tolerance and reduced gastrointestinal side effects. Their low cost, prompt relief of symptoms, and status as first-line treatment predominate the treatment for AS. NSAIDs are also the foundation treatment prior to switching to biologics, affirming their prominence in early and chronic disease control.
Tumor Necrosis Factor (TNF) inhibitors are projected to be the fastest-growing segment due to their proven efficacy in halting disease progression and improving spinal mobility in ankylosing spondylitis patients. Rising biologics adoption, increased physician preference, and expanding approvals for biosimilars are accelerating their use, especially among patients unresponsive to NSAIDs.
The oral route of administration continues to dominate the global ankylosing spondylitis (AS) treatment market due to its convenience, patient compliance, and cost-effectiveness. Advances in oral products, e.g., controlled-release NSAIDs and the availability of oral JAK inhibitors, have improved drug efficacy with minimal side effects. This superiority is supported by easy self-administration, decreasing outpatient visits, and the wide scope of oral treatments, which brings drugs to an increased patient base.
The injectable route is expected to be the fastest-growing market segment in global ankylosing spondylitis treatment owing to the expanding use of biologics such as TNF and IL-17 inhibitors, which need to be administered parenterally. These injectables provide targeted, long-acting relief, especially for patients not responsive to oral treatments. Improvement in self-injection devices and biosimilar launches further improve access and compliance, fueling speedy growth in this segment.
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North America holds a dominant position in the global ankylosing spondylitis treatment market due to advanced healthcare infrastructure, high awareness, and early adoption of biologics. The region is supported by robust R&D investments, good reimbursement policies, and the presence of big pharmaceutical companies. Rising incidence of autoimmune diseases, along with ongoing innovation in drug discovery and targeted therapies, further consolidates North America's market leadership and growth prospects in ankylosing spondylitis treatment.
The United States is the market leader for North American ankylosing spondylitis treatment based on its high disease incidence, broad utilization of sophisticated biologics, and aggressive R&D spending. Strong pipelines of clinical trials, generous insurance coverage, and early biosimilar uptake expand access to treatment. Having top pharmaceutical players and specialty rheumatology centers there also boosts innovation, making the U.S. the dominant force in the region's therapeutic innovation and revenue expansion.
Canada contributes significantly to the ankylosing spondylitis treatment market with rising diagnosis rates and increased access to advanced therapies through its public healthcare system. Government encouragement of biologics and biosimilars, coupled with domestic efforts for early treatment, has enhanced outcomes. Sustained research investment and patient-oriented care models, in combination with increased awareness initiatives, make Canada a significant growth driver of North America's ankylosing spondylitis treatment paradigm shift.
Europe is a leading player in the global ankylosing spondylitis treatment market, aided by a robust healthcare infrastructure, favorable reimbursement systems, and early adoption of biologics. Germany, France, and the UK are leading countries in therapeutic innovation and clinical research. The region is helped by collaborative efforts, increasing awareness, and expanding biosimilar acceptance, which increases treatment accessibility. Rising diagnosis rates and government-sponsored health programs continue to drive steady market growth throughout Europe.
Germany stands as a leader in Europe’s ankylosing spondylitis treatment market due to its advanced healthcare system, strong pharmaceutical presence, and widespread use of biologics. Strong diagnostic rates and established rheumatology clinics facilitate early intervention and ongoing care. The nation also accommodates high numbers of clinical trials and encourages biosimilar uptake, enhancing the affordability of treatment. Government assistance in research and novel therapies makes Germany a focal point for AS management and therapeutic innovation.
France drives the treatment of ankylosing spondylitis within the market with full healthcare coverage, robust medical network, and greater public awareness about health. The nation supports early screening with and offers open access to biologic drugs through national health coverage. French research centers actively participate in drug development and clinical trials, particularly for TNF and IL-17 inhibitors. These initiatives, combined with biosimilar integration, continue to grow France's presence in the European AS treatment market.
Asia Pacific is becoming a fast-growing market for global ankylosing spondylitis treatment, fueled by growing disease awareness, increasing healthcare access, and rising biologic adoption. China, India, and Japan are investing in healthcare infrastructure and clinical trials. Government initiatives to support biosimilars, expanding patient populations, and collaborations between local and multinational pharmaceutical companies are fueling treatment availability, making Asia Pacific a growth driver for the AS market.
Japan is a key player in Asia Pacific's ankylosing spondylitis treatment market because of its well-developed healthcare infrastructure, high level of disease awareness, and favorable regulatory environment for biologics. Early diagnosis and individualized treatment by rheumatology experts are prioritized in the country. Local pharma companies have collaborations with international players in the area of biosimilar development and clinical trials. The aging population of Japan and health-conscious policies of the government also increase the need for new AS therapies and long-term disease management solutions.
South Korea is a major player in the AS treatment market through its strong biotechnology industry, comprehensive healthcare coverage, and growing uptake of biologics and biosimilars. The research focus and medical innovation of the country facilitate clinical development of new anti-inflammatory and immune-modulating treatments. Early rheumatologic care promotion and public awareness campaigns by the government have driven up diagnosis rates, making South Korea a vibrant and expanding market for AS treatment options.
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Rising Prevalence of Ankylosing Spondylitis
Advancements in Biologic Therapies
Limited Awareness and Late Diagnosis
Adverse Effects and Contraindications of Long-Term Drug Use
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Global ankylosing spondylitis treatment market competition is characterized by innovation-fostered competition among major players such as AbbVie Inc., Pfizer Inc., Eli Lilly and Company, Novartis AG, and Johnson & Johnson. Firms emphasize biologic innovation, increasing biosimilar offerings, and strategic collaborations. AbbVie leverages Humira's heritage while driving Rinvoq forward, while Novartis fortifies market presence with Cosentyx and aggressive participation in clinical trials for the next-generation IL-17 inhibitors.
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
As per SkyQuest analysis, the global ankylosing spondylitis (AS) treatment market is undergoing a transformative evolution driven by a rising patient population, breakthrough biologics, AI-powered diagnostics, and personalized medicine innovations. From long-acting NSAIDs to next-generation TNF and IL-17 inhibitors, treatment options are growing both in availability and specificity. With the introduction of AI platforms such as VertXGradeNet, diagnostics are becoming streamlined, while companies such as Infinimmune and Sudo Biosciences are transforming therapeutic pipelines with next-generation immunology.
Regionally, Europe and North America lead with robust infrastructure and biosimilar adoption, and Asia Pacific is a dynamic growth hub. With healthcare ecosystems adopting innovation and collaboration, AS treatment paradigms are set to be more personalized, effective, and patient-focused, favoring long-term disease control and improved global outcomes.
Report Metric | Details |
---|---|
Market size value in 2023 | USD 3.1 billion |
Market size value in 2032 | USD 6.09 billion |
Growth Rate | 7.8% |
Base year | 2024 |
Forecast period | 2025-2032 |
Forecast Unit (Value) | USD Billion |
Segments covered |
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Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
Companies covered |
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Table Of Content
Executive Summary
Market overview
Parent Market Analysis
Market overview
Market size
KEY MARKET INSIGHTS
COVID IMPACT
MARKET DYNAMICS & OUTLOOK
Market Size by Region
KEY COMPANY PROFILES
Methodology
For the Ankylosing Spondylitis Treatment Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Ankylosing Spondylitis Treatment Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
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Global Ankylosing Spondylitis Treatment Market size was valued at USD 4.70 Billion in 2023 poised to grow from USD 4.92 Billion in 2024 to USD 7.14 Billion by 2032, growing at a CAGR of 4.75% in the forecast period (2025-2032).
Global ankylosing spondylitis treatment market competition is characterized by innovation-fostered competition among major players such as AbbVie Inc., Pfizer Inc., Eli Lilly and Company, Novartis AG, and Johnson & Johnson. Firms emphasize biologic innovation, increasing biosimilar offerings, and strategic collaborations. AbbVie leverages Humira's heritage while driving Rinvoq forward, while Novartis fortifies market presence with Cosentyx and aggressive participation in clinical trials for the next-generation IL-17 inhibitors. 'AbbVie Inc. (USA)', 'Pfizer Inc. (USA)', 'Eli Lilly and Company (USA)', 'Johnson & Johnson (USA)', 'Novartis AG (Switzerland)', 'Merck & Co., Inc. (USA)', 'Amgen Inc. (USA)', 'Boehringer Ingelheim GmbH (Germany)', 'UCB S.A. (Belgium)', 'Roche Holding AG (Switzerland)', 'AstraZeneca plc (United Kingdom)', 'Bristol-Myers Squibb Company (USA)', 'Biocon Limited (India)', 'Samsung Bioepis Co., Ltd. (South Korea)', 'Takeda Pharmaceutical Company Limited (Japan)'
The increasing global prevalence of ankylosing spondylitis, particularly among younger populations, is a major driver. This increase in diagnosed cases is driving demand for effective treatments, and healthcare systems and pharmaceutical firms are investing more in drug development, diagnostic technologies, and patient-focused care strategies to address increasing therapeutic demands.
Biologics Innovation Driving Therapeutic Evolution: The transition to biologics, such as TNF and IL-17 inhibitors, is revolutionizing ankylosing spondylitis therapy by providing targeted therapies with better efficacy. Ongoing R&D and growing biosimilar portfolios are driving market growth, as providers and patients increasingly prefer biologics for long-term disease management and enhanced quality of life.
What makes Reimbursement Policies in North America Favorable for AS Care?
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