USD 7.41 billion
Global ADME Toxicology Testing Market Size, Share, Growth Analysis, By Technology(Cell Culture, High Throughput), By Application(Systemic Toxicity, Renal Toxicity) - Industry Forecast 2024-2031
Report ID:
SQMIG35D2140 |
Region:
Global |
Published Date: March, 2024
Pages:
219
|
Tables:
66 |
Figures:
75
Global ADME Toxicology Testing Market Insights
Global ADME Toxicology Testing Market size was valued at USD 7.41 billion in 2022 and is poised to grow from USD 8.26 billion in 2023 to USD 19.74 billion by 2031, growing at a CAGR of 11.50% during the forecast period (2024-2031).
The purpose of the ADME toxicology testing market is to evaluate the pharmacokinetics and toxicokinetics of substances, providing vital information on their absorption rates, tissue distribution, metabolism, and elimination pathways. By assessing the potential toxicity and adverse effects of drugs and chemicals, ADME testing helps in early-stage drug development, preclinical safety assessments, and risk management. The driving factor of the ADME toxicology testing market is the increasing demand for safer and more effective drugs. With stringent regulatory requirements and the need to ensure patient safety, pharmaceutical companies and researchers rely on ADME testing to assess the potential toxicity and predict the pharmacokinetic properties of their drug candidates.
Challenges in the ADME toxicology testing market include the complexity of human physiology and interindividual variations, which can influence the outcomes and interpretations of test results. The rapid advancements in drug discovery and development also present challenges in keeping up with the evolving regulatory guidelines and ensuring the accuracy and reliability of ADME testing methods. The global ADME toxicology testing market serves the purpose of evaluating the pharmacokinetics and toxicokinetics of drugs and chemicals, ensuring their safety and efficacy. It is driven by the demand for safer drugs and regulatory compliance. However, challenges such as cost constraints and the need for alternative testing methods exist. Nonetheless, opportunities arise from advancements in in vitro and in silico testing approaches and the potential for personalized medicine applications.
US ADME Toxicology Testing Market is poised to grow at sustainable CAGR for the next forecast year.
Market snapshot - 2024-2031
Global Market Size
Largest Segment
Cell Culture
Fastest Growth
Cell Culture
Growth Rate
11.50% CAGR
Global ADME Toxicology Testing Market ($ Bn)
Country Share for North America Region (%)
Global ADME Toxicology Testing Market By Technology ($ Bn)
Global ADME Toxicology Testing Market By Technology (%)
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Global ADME Toxicology Testing Market Segmental Analysis
The global ADME toxicology testing market is segmented on the basis of technology, application, and region. By Technology, the market is segmented into Cell Culture, High Throughput, Molecular Imaging, and OMICS Technology. By Application, the market is segmented into Systemic Toxicity, Renal Toxicity, Hepatotoxicity, Neurotoxicity, and Others. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
ADME Toxicology Testing Market Analysis by Technology
Cell culture technology holds a prominent position in ADME toxicology testing due to its ability to mimic in vivo conditions and provide valuable insights into drug absorption, distribution, metabolism, and excretion. Cell-based assays offer a cost-effective and efficient approach to studying drug interactions, toxicity, and efficacy. With the advancements in 3D cell culture models and organoid systems, cell culture technology has gained popularity in preclinical drug development, enabling researchers to assess ADME properties and predict potential toxicities.
OMICS technology, including genomics, transcriptomics, proteomics, and metabolomics, is the fastest-growing segment in the ADME toxicology testing market. OMICS technologies allow for a comprehensive analysis of molecular changes induced by drugs or chemicals, providing a deeper understanding of their effects on cellular processes. By studying the expression levels of genes, proteins, and metabolites, OMICS technology aids in identifying biomarkers, predicting drug responses, and elucidating the mechanisms of toxicity. The integration of OMICS data with bioinformatics and computational modeling further enhances the predictive power of ADME toxicology testing.
ADME Toxicology Testing Market Analysis by Application
The largest segment is Hepatotoxicity testing. Hepatotoxicity testing, which focuses on assessing drug-induced liver toxicity, stands as the largest segment in the ADME toxicology testing market. The liver plays a crucial role in metabolizing drugs, making it a vital organ for toxicity assessment. With a significant rise in drug development and an increased focus on drug safety, hepatotoxicity testing has gained substantial traction. The attractiveness of hepatotoxicity testing stems from its significance in identifying potential risks associated with drug-induced liver damage. By accurately assessing the liver's response to drug compounds, this testing method aids in ensuring the safety and efficacy of pharmaceutical products.
The fastest-growing segment, Neurotoxicity testing, has been witnessing exceptional expansion in recent years. This testing method assesses the potential adverse effects of drug compounds on the nervous system, including the brain and peripheral nerves. The rising prevalence of neurological disorders and the increasing demand for neuroprotective drugs have propelled the growth of this segment. Neurotoxicity testing offers valuable insights into the safety of drugs targeting the nervous system, helping pharmaceutical companies identify potential risks before clinical trials or market release. By detecting and mitigating potential neurotoxic effects early in the drug development process, this testing method plays a vital role in safeguarding patient well-being and ensuring the success of pharmaceutical endeavors.
Global ADME Toxicology Testing Market By Technology, 2023 (%)
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Global ADME Toxicology Testing Market Regional Insights
North America continues to dominate the global ADME toxicology testing market. The region's dominance is primarily attributed to several factors. Firstly, North America houses a robust pharmaceutical industry with a significant presence of key market players, including pharmaceutical companies, contract research organizations (CROs), and academic research institutions. These entities drive the demand for ADME toxicology testing services to ensure the safety and efficacy of drug candidates. North America boasts advanced healthcare infrastructure, well-established regulatory frameworks, and a strong emphasis on research and development. The region's regulatory bodies, such as the U.S. Food and Drug Administration (FDA), enforce stringent guidelines for drug safety evaluation, making ADME toxicology testing an essential component of the drug development process. This regulatory environment stimulates the demand for toxicology testing services and propels the dominance of North America in the market.
The Asia Pacific region is experiencing significant growth and emerges as the fastest-growing region in the global ADME toxicology testing market. Several factors contribute to the region's rapid expansion. Firstly, the Asia Pacific region has witnessed substantial growth in its pharmaceutical and biotechnology industries, driven by factors such as a large patient population, increasing healthcare expenditure, and rising demand for innovative therapies. Countries like China, India, and Japan have made significant investments in research and development infrastructure, fostering the growth of the ADME toxicology testing market. These nations are becoming preferred destinations for clinical trials and drug development, leading to a surge in the demand for toxicology testing services.
Global ADME Toxicology Testing Market By Geography, 2024-2031
- Largest
- Fastest
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Global ADME Toxicology Testing Market Dynamics
ADME Toxicology Testing Market Drivers
Increasing Drug Development Activities
- The pharmaceutical industry experienced a surge in drug development activities in 2022, driven by the need for innovative therapeutics and treatments for various diseases. This heightened focus on drug discovery and development directly contributed to the growth of the ADME toxicology testing market. Pharmaceutical companies and research organizations extensively relied on toxicology testing to assess the safety and efficacy of their drug candidates before progressing to clinical trials and market release.
Stringent Regulatory Guidelines
- Regulatory bodies across the globe have implemented stringent guidelines to ensure the safety and efficacy of pharmaceutical products. ADME toxicology testing has become an essential component of the regulatory evaluation process. The need to comply with these regulations and obtain regulatory approvals acted as a driving force for the market growth in 2022.
ADME Toxicology Testing Market Restraints
High Cost of ADME Toxicology Testing
- The cost associated with ADME toxicology testing can be significant, involving various experimental procedures, equipment, and skilled personnel. This cost factor posed a restraint to the market growth in 2022, particularly for small and medium-sized pharmaceutical companies with limited budgets.
Ethical Concerns and Animal Testing Alternatives
- Increasing societal awareness and ethical concerns regarding animal welfare have prompted efforts to reduce or replace animal testing in toxicology studies. While the development and adoption of alternative testing methods hold promise, the transition from animal models to alternative approaches remains a challenge. This restraint was observed in 2022, as the industry sought to strike a balance between ensuring accurate toxicological evaluations and minimizing animal usage.
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Global ADME Toxicology Testing Market Competitive Landscape
The global ADME toxicology testing Market features a competitive landscape characterized by the presence of several prominent players offering a range of services and solutions. These companies strive to enhance their market position through continuous innovation, strategic collaborations, and expansions. The competitive landscape is shaped by factors such as technological advancements, regulatory compliance, and the ability to provide comprehensive and reliable toxicology testing services. Strategic collaborations and partnerships also play a crucial role in shaping the competitive landscape of the ADME toxicology testing market. Companies often form alliances with academic institutions, regulatory bodies, and other industry players to gain access to specialized knowledge, expand their service offerings, and establish a global presence. These collaborations facilitate knowledge exchange, technology transfer, and the development of standardized testing protocols, ultimately benefiting the industry as a whole.
ADME Toxicology Testing Market Top Player’s Company Profiles
- Charles River Laboratories (US)
- Covance Inc. (US)
- Eurofins Scientific (Luxembourg)
- WuXi AppTec (China)
- Merck KGaA (Germany)
- Thermo Fisher Scientific (US)
- Cyprotex (UK)
- BioIVT (US)
- SGS SA (Switzerland)
- GE Healthcare (US)
- Promega Corporation (US)
- Absorption Systems (US)
- Catalent, Inc. (US)
- Lonza Group Ltd. (Switzerland)
- Evotec SE (Germany)
- Cyagen Biosciences (China)
- In Vitro ADMET Laboratories LLC (US)
- HD Biosciences (China)
- Sekisui XenoTech, LLC (US)
- Shanghai Medicilon Inc. (China)
ADME Toxicology Testing Market Recent Developments
- In September 2022, Thermo Fisher Scientific, a global leader in scientific research and services, introduced a high-throughput in vitro ADME toxicology testing platform. This platform enabled faster and more efficient screening of drug candidates, helping researchers identify potential toxic effects earlier in the drug development process.
- In May 2022, Charles River Laboratories, a prominent contract research organization (CRO), launched its ADME toxicology testing services for the Asia Pacific region. This expansion aimed to meet the growing demand for drug safety assessment in the region and support pharmaceutical companies in their drug development efforts.
- In January 2022, Eurofins Discovery, a leading provider of drug discovery and development services, announced the expansion of its ADME toxicology testing capabilities. The company introduced new in vitro models and predictive tools to enhance the accuracy and efficiency of toxicology evaluations.
Global ADME Toxicology Testing Key Market Trends
- In vitro and In Silico Testing Advancements: The advancement of in vitro and in silico testing methods gained momentum in 2022. These technologies offer alternatives to traditional animal testing and provide efficient, cost-effective, and ethical approaches to toxicology evaluation. The development and adoption of in vitro assays and predictive modeling techniques witnessed notable progress, enabling more accurate and reliable toxicology predictions.
- Shift towards Alternative Testing Methods: Regulatory agencies worldwide, including the FDA and the European Medicines Agency (EMA), have been actively promoting the development and adoption of alternative testing methods to improve animal welfare and enhance the predictability and relevance of toxicity testing. The advancements in in vitro testing, microphysiological systems (organ-on-a-chip), and computational modeling techniques are driving this trend. Companies are investing in research and development efforts to innovate and validate alternative testing approaches, enabling a more ethical and sustainable toxicology testing landscape.
Global ADME Toxicology Testing Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyzes the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
According to our global ADME toxicology testing market analysis, the increasing need for effective and safe drugs, stringent regulatory requirements, and the growing focus on personalized medicine are the key growth drivers. Pharmaceutical companies rely on ADME toxicology testing to comply with regulatory guidelines and obtain approvals for clinical trials and product launches. It ensures that drugs are thoroughly evaluated for potential adverse effects and provides valuable insights into their pharmacokinetics and potential interactions with other drugs. The global ADME toxicology testing market is experiencing substantial growth driven by factors like the demand for safe and effective drugs, regulatory compliance, and technological advancements. With the continuous development of innovative testing methods and a focus on regulatory compliance, this market plays a vital role in ensuring the safety and efficacy of pharmaceutical products, ultimately benefiting patients worldwide.
| Report Metric | Details |
|---|---|
| Market size value in 2023 | USD 7.41 billion |
| Market size value in 2031 | USD 19.74 billion |
| Growth Rate | 11.50% |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
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| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Global ADME Toxicology Testing Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Global ADME Toxicology Testing Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Global ADME Toxicology Testing Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Global ADME Toxicology Testing Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Global ADME Toxicology Testing Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Global ADME Toxicology Testing Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
Global ADME Toxicology Testing Market Report Snapshots
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