Preparative and Process Chromatography Market Size, Share, and Growth Analysis

Preparative and Process Chromatography Market By Product Type (Process Chromatography, System), By Type (Liquid Chromatography, HPLC), By Application (Clinical Diagnostics, Environmental Testing), By End User (Hospital, Research Laboratories), By Region - Industry Forecast 2025-2032


Report ID: SQMIG35H2065 | Region: Global | Published Date: March, 2025
Pages: 219 |Tables: 64 |Figures: 77

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Preparative and Process Chromatography Market Insights

Preparative and Process Chromatography Market size was valued at USD 10.4 billion in 2023 and is poised to grow from USD 11.68 billion in 2024 to USD 29.54 billion by 2032, growing at a CAGR of 12.3% during the forecast period (2025-2032).

Large-scale integration of liquid chromatography techniques in downstream processing has accelerated the growth of this field. technological development, and high demand for preparative techniques have all played a role. Throughout the forecast period, monoclonal antibodies are forecast to be more in demand and being accepted for use in the pharmaceutical and biotechnology sectors.

This is explained by the greater involvement of service providers in chromatographic-based antibody separation methods including affinity chromatography and column displacement chromatography. Chromatography is a process that is used for separating constituents or solutes of a mixture based on the relative quantities of each solute dispersed between a moving fluid stream, known as the mobile phase, and a contiguous stationary phase.

The method of preparative chromatography is used to separate components of complicated mixtures. It is used in the pharmaceutical industry to free molecules of impurities before they are purified and used for a range of tasks, with clinical supply in the case of active medicinal components.

Process chromatography is an analytical technique that allows online mixture component separation and quantification in a chemical process. By obtaining a set number of samples, separating the chemical components using adsorption or partitioning columns, and then determining the concentration of each component using a detector, on-line chromatograph analyzers can work continuously and automatically.

US Preparative and Process Chromatography Market is poised to grow at a sustainable CAGR for the next forecast year.

Market snapshot - 2025-2032

Global Market Size

USD 10.4 billion

Largest Segment

Liquid chromatography

Fastest Growth

Liquid chromatography

Growth Rate

12.3% CAGR

Global Preparative And Process Chromatography Market ($ Bn)
Country Share for North america Region (%)

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Preparative and Process Chromatography Market Segments Analysis

Global Preparative and Process Chromatography Market is segmented by Product Type, Type, Application, End User and region. Based on Product Type, the market is segmented into Process Chromatography, System, Consumable, Reagents, Resins, Columns and Service. Based on Type, the market is segmented into Liquid Chromatography, HPLC, Flash/Column Chromatography, Ion-exchange chromatography, Size-exclusion chromatography, Affinity chromatography, Gas Chromatography, Thin Layer Chromatography, Paper Chromatography, Gel-permeation (Molecular Sieve) Chromatography and Hydrophobic Interaction Chromatography. Based on Application, the market is segmented into Clinical Diagnostics, Environmental Testing, Forensic Tests, Life Sciences and Others. Based on End User, the market is segmented into Hospital, Research Laboratories, Biotechnology, Pharmaceutical Industries and Others. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.

Preparative and Process Chromatography Market Analysis by Type

The liquid chromatography segment accounted for the largest share of 28.11% owing to the general application across many industries. Depending upon the type, some major preparative and process chromatographic techniques include liquid chromatography (LC), HPLC,and Gas chromatography. Different types of this technique are used to isolate bioactive molecules from different sources. In the manufacturing process, LC plays an important role in ensuring product quality. Hence, the rapidly growing pharmaceutical and specialty chemicals industry has shown growing interest in this market segment, resulting in significant growth. The hydrophobic interaction chromatography segment is expected to grow the fastest over the forecast period.

Preparative and Process Chromatography Market Analysis by End Use

The pharmaceutical segment accounted for the largest share of sales, due to the high usage of preparative and process chromatography in drug safety assessment. The demand for developing an effective vaccine against the novel coronavirus in a reduced timeframe has led to the development of unique vaccine strategies, such as viral vector-based vaccines, nucleic acid-based vaccines, and virus-like particle vaccines. The food segment is expected to view significant growth over the forecast period owing to the increasing analysis associated with food.

Global Preparative And Process Chromatography Market By Type

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Preparative and Process Chromatography Market Regional Insights

North America captured the largest revenue share of 32.11% in 2021. The regional market is growing because there are a lot of key players, and the companies are investing in research and development to manage diseases. The United States is a major player in regional market growth because it is investing more in R&D. This is being done by both private and public entities.

The Asia Pacific is expected to experience a significant growth rate over the next few years. The growth of the pharmaceutical and biotechnology sectors in the region is expected to increase the market growth in the region. The growth of key market players in Asia is further driving the regional market.

Global Preparative And Process Chromatography Market By Region
  • Largest
  • Fastest

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Preparative and Process Chromatography Market Dynamics

Preparative and Process Chromatography Market Drivers

Increased Application of Chromatography to Bolster Market Growth

  • Revenue growth in the global chromatography technique is driven by a wide range of growing applications, and this technique can provide an exact separation and purification which can be achieved with this technique. This technique uses a process called chromatography to separate a very small amount (often parts per million) of the multiple component mixtures. This aids the analyst in quantitative determination of components of mixtures. Increasing application of chromatography due to such advantages is expected to increase revenue growth of the market.

Preparative and Process Chromatography Market Restraints

Lack of Skilled Workers to Hinder Market Growth

  • The preparative and process chromatography market growth is substantially hampered by several unfavorable factors. Due to preparative and process chromatography's time-consuming and costly aspects, the market is expected to be a negative growth driver during the review period. This factor is expected to apply restraints to market growth. In addition, requirements of experts to handle the equipment and lack of minimization options are likely to hamper market growth during this period.

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Preparative and Process Chromatography Market Competitive Landscape

Players in the global market are investing in R&D activities to stay ahead in the competition. Players are also focusing on merger & acquisition to expand their consumer base.

Top Players in Preparative and Process Chromatography Market

  • Merck KGaA (Germany)
  • Bio-Rad Laboratories, Inc. (USA) 
  • Repligen Corporation (USA) 
  • Tosoh Bioscience (Japan) 
  • Sartorius AG (Germany) 
  • Thermo Fisher Scientific Inc. (USA) 
  • Agilent Technologies, Inc. (USA) 
  • Purolite Corporation (USA) 
  • Knauer Wissenschaftliche Geräte GmbH (Germany) 
  • GEA Group AG (Germany) 
  • Waters Corporation (USA) 
  • Atoll GmbH (Germany) 
  • Novasep (France) 
  • Danaher Corporation (USA) 
  • Shimadzu Corporation (Japan) 
  • Pall Corporation (USA) 
  • Avantor, Inc. (USA) 
  • YMC Co., Ltd. (Japan) 
  • BioSepra Process SAS (France)

Preparative and Process Chromatography Market Recent Developments

  • In 2021, The Waters Arc Premier System, designed for chromatographic separations on 2.5 to 3.5 micron columns, was introduced by Waters.
  • In 2021, Sartorius and Novasep A contract was made by Stedim Biotech selling Sartorius the former business's chromatography equipment segment. By partnering with a proven leader in the industry, Novasep will be able to accelerate the growth of its chromatography division.

Preparative and Process Chromatography Key Market Trends

Preparative and Process Chromatography Market SkyQuest Analysis

SkyQuest's ABIRAW (Advanced Business Intelligence, Research and Analysis Wing) is our Business Information Services team that collects, collates, Co-relates and analyses the Data collected by means of Primary Exploratory Research backed by the robust Secondary Desk research.

According to our global Preparative and Process Chromatography Market analysis, although more and more money is pouring into pharmaceutical departments, hospitals actually account for nearly two-fifths of the whole adoption of pharmaceutical products in the U S, suggesting that their acceptance is increasing annually.

Report Metric Details
Market size value in 2023 USD 10.4 billion
Market size value in 2032 USD 29.54 billion
Growth Rate 12.3%
Base year 2024
Forecast period 2025-2032
Forecast Unit (Value) USD Billion
Segments covered
  • Product Type
    • Process Chromatography, System (Multi-use Batch Chromatography Systems, Single-use Batch Chromatography Systems, Continuous Chromatography Systems), Consumable, Reagents, Resins (Affinity Resins, Ion-exchange Resins, Size-exclusion Resins, Hydrophobic Interaction Resins, Reversed Phase Resins, Mixed-mode/Multi-mode Resins), Columns (Prepacked Columns, Automated Columns, Manual Columns), Service
  • Type
    • Liquid Chromatography, HPLC, Flash/Column Chromatography, Ion-exchange chromatography, Size-exclusion chromatography, Affinity chromatography, Gas Chromatography, Thin Layer Chromatography, Paper Chromatography, Gel-permeation (Molecular Sieve) Chromatography, Hydrophobic Interaction Chromatography
  • Application
    • Clinical Diagnostics, Environmental Testing, Forensic Tests, Life Sciences, Others
  • End User
    • Hospital, Research Laboratories, Biotechnology, Pharmaceutical Industries, Others
Regions covered North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA)
Companies covered
  • Merck KGaA (Germany)
  • Bio-Rad Laboratories, Inc. (USA) 
  • Repligen Corporation (USA) 
  • Tosoh Bioscience (Japan) 
  • Sartorius AG (Germany) 
  • Thermo Fisher Scientific Inc. (USA) 
  • Agilent Technologies, Inc. (USA) 
  • Purolite Corporation (USA) 
  • Knauer Wissenschaftliche Geräte GmbH (Germany) 
  • GEA Group AG (Germany) 
  • Waters Corporation (USA) 
  • Atoll GmbH (Germany) 
  • Novasep (France) 
  • Danaher Corporation (USA) 
  • Shimadzu Corporation (Japan) 
  • Pall Corporation (USA) 
  • Avantor, Inc. (USA) 
  • YMC Co., Ltd. (Japan) 
  • BioSepra Process SAS (France)
Customization scope

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  • Market dynamics & outlook
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Table Of Content

Executive Summary

Market overview

  • Exhibit: Executive Summary – Chart on Market Overview
  • Exhibit: Executive Summary – Data Table on Market Overview
  • Exhibit: Executive Summary – Chart on Preparative and Process Chromatography Market Characteristics
  • Exhibit: Executive Summary – Chart on Market by Geography
  • Exhibit: Executive Summary – Chart on Market Segmentation
  • Exhibit: Executive Summary – Chart on Incremental Growth
  • Exhibit: Executive Summary – Data Table on Incremental Growth
  • Exhibit: Executive Summary – Chart on Vendor Market Positioning

Parent Market Analysis

Market overview

Market size

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • SWOT Analysis

KEY MARKET INSIGHTS

  • Technology Analysis
    • (Exhibit: Data Table: Name of technology and details)
  • Pricing Analysis
    • (Exhibit: Data Table: Name of technology and pricing details)
  • Supply Chain Analysis
    • (Exhibit: Detailed Supply Chain Presentation)
  • Value Chain Analysis
    • (Exhibit: Detailed Value Chain Presentation)
  • Ecosystem Of the Market
    • Exhibit: Parent Market Ecosystem Market Analysis
    • Exhibit: Market Characteristics of Parent Market
  • IP Analysis
    • (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
  • Trade Analysis
    • (Exhibit: Data Table: Import and Export data details)
  • Startup Analysis
    • (Exhibit: Data Table: Emerging startups details)
  • Raw Material Analysis
    • (Exhibit: Data Table: Mapping of key raw materials)
  • Innovation Matrix
    • (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
  • Pipeline product Analysis
    • (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
  • Macroeconomic Indicators

COVID IMPACT

  • Introduction
  • Impact On Economy—scenario Assessment
    • Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
  • Revised Market Size
    • Exhibit: Data Table on Preparative and Process Chromatography Market size and forecast 2021-2027 ($ million)
  • Impact Of COVID On Key Segments
    • Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
  • COVID Strategies By Company
    • Exhibit: Analysis on key strategies adopted by companies

MARKET DYNAMICS & OUTLOOK

  • Market Dynamics
    • Exhibit: Impact analysis of DROC, 2021
      • Drivers
      • Opportunities
      • Restraints
      • Challenges
  • Regulatory Landscape
    • Exhibit: Data Table on regulation from different region
  • SWOT Analysis
  • Porters Analysis
    • Competitive rivalry
      • Exhibit: Competitive rivalry Impact of key factors, 2021
    • Threat of substitute products
      • Exhibit: Threat of Substitute Products Impact of key factors, 2021
    • Bargaining power of buyers
      • Exhibit: buyers bargaining power Impact of key factors, 2021
    • Threat of new entrants
      • Exhibit: Threat of new entrants Impact of key factors, 2021
    • Bargaining power of suppliers
      • Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
  • Skyquest special insights on future disruptions
    • Political Impact
    • Economic impact
    • Social Impact
    • Technical Impact
    • Environmental Impact
    • Legal Impact

Market Size by Region

  • Chart on Market share by geography 2021-2027 (%)
  • Data Table on Market share by geography 2021-2027(%)
  • North America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • USA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Canada
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Europe
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Germany
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Spain
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • France
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • UK
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Europe
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Asia Pacific
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • China
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • India
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Japan
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Korea
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of Asia Pacific
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Latin America
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • Brazil
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of South America
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
  • Middle East & Africa (MEA)
    • Chart on Market share by country 2021-2027 (%)
    • Data Table on Market share by country 2021-2027(%)
    • GCC Countries
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • South Africa
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)
    • Rest of MEA
      • Exhibit: Chart on Market share 2021-2027 (%)
      • Exhibit: Market size and forecast 2021-2027 ($ million)

KEY COMPANY PROFILES

  • Competitive Landscape
    • Total number of companies covered
      • Exhibit: companies covered in the report, 2021
    • Top companies market positioning
      • Exhibit: company positioning matrix, 2021
    • Top companies market Share
      • Exhibit: Pie chart analysis on company market share, 2021(%)

Methodology

For the Preparative and Process Chromatography Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:

1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.

2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Preparative and Process Chromatography Market.

3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.

4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.

Analyst Support

Customization Options

With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Preparative and Process Chromatography Market:

Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.

Regional Analysis: Further analysis of the Preparative and Process Chromatography Market for additional countries.

Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.

Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.

Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.

Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.

Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.

Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.

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FAQs

Preparative and Process Chromatography Market size was valued at USD 9.96 Billion in 2023 and is poised to grow from USD 11.13 Billion in 2024 to USD 26.98 Billion by 2032, growing at a CAGR of 11.7% during the forecast period (2025-2032).

Players in the global market are investing in R&D activities to stay ahead in the competition. Players are also focusing on merger & acquisition to expand their consumer base. 'Agilent Technologies, Inc.', 'GE Healthcare Life Sciences', 'Merck KGaA', 'Danaher Corporation', 'Waters Corporation', 'Shimadzu Corporation', 'Bio-Rad Laboratories, Inc.', 'Thermo Fisher Scientific, Inc.', 'Novasep Holding S.A.S.', 'Knauer GmbH', 'Chiral Technologies, Inc.', 'Kromasil AB', 'PALL Corporation', 'Mitsubishi Chemical Corporation', 'YMC Co., Ltd.', 'ACE Chemicals (Tianjin) Co., Ltd.', 'GL Sciences, Inc.', 'Sepax Technologies, Inc.', 'PhyNexus, Inc.', 'GL Sciences Inc.', 'In 2021, The Waters Arc Premier System, designed for chromatographic separations on 2.5 to 3.5 micron columns, was introduced by Waters.', 'In 2021, Sartorius and Novasep A contract was made by Stedim Biotech selling Sartorius the former business's chromatography equipment segment. By partnering with a proven leader in the industry, Novasep will be able to accelerate the growth of its chromatography division.'

Revenue growth in the global chromatography technique is driven by a wide range of growing applications, and this technique can provide an exact separation and purification which can be achieved with this technique. This technique uses a process called chromatography to separate a very small amount (often parts per million) of the multiple component mixtures. This aids the analyst in quantitative determination of components of mixtures. Increasing application of chromatography due to such advantages is expected to increase revenue growth of the market.

According to the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA), pharmaceutical entities spend nearly USD 149.8 Bn every year on research, thereby supporting the research that is going on in the preparative and process chromatography market. Such research is contributing to the economic growth of the market. Moreover, numerous advancements in this market have created extensive demand and prevented due growth. FPLC (Fast Protein Liquid Chromatography) is being used for purifying biomolecules (say – proteins).

North America captured the largest revenue share of 32.11% in 2021. The regional market is growing because there are a lot of key players, and the companies are investing in research and development to manage diseases. The United States is a major player in regional market growth because it is investing more in R&D. This is being done by both private and public entities.

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